Altered regulatory T cell homeostasis in patients with [CD4.sup.+] lymphopenia following allogeneic hematopoietic stem cell transplantation

[CD4.sup.+][CD25.sup.+][Foxp3.sup.+] Tregs have an indispensable role in the maintenance of tolerance after allogeneic HSC transplantation (HSCT). Patients with chronic graft-versus-host disease (GVHD) have fewer circulating Tregs, but the mechanisms that lead to this deficiency of Tregs after HSCT...

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Veröffentlicht in:	The Journal of clinical investigation 2010-05, Vol.120 (5), p.1479
Hauptverfasser:	Matsuoka, Ken-ichi, Kim, Haesook T, McDonough, Sean, Bascug, Gregory, Warshauer, Ben, Koreth, John, Cutler, Corey, Ho, Vincent T, Alyea, Edwin P, Antin, Joseph H, Soiffer, Robert J, Ritz, Jerome
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cancer Care and treatment Hematopoietic stem cells Homeostasis Lymphocytopenia Prevention Properties Risk factors T cells Transplantation
Online-Zugang:	Volltext
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