Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3[beta]?

Male Irs2.sup.-/- .sup.mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in Irs2.sup.-/- .sup.mice. We identify retarded renal growth in male and female Irs2.sup.-/- .sup.mice, independent of diabetes....

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Veröffentlicht in:	BMC developmental biology 2010-07, Vol.10, p.73
Hauptverfasser:	Carew, Rosemarie M, Sadagurski, Marianna, Goldschmeding, Roel, Martin, Finian, White, Morris F, Brazil, Derek P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal development Chromosome deletion Development and progression Genetic aspects Insulin Receptors Type 2 diabetes
Online-Zugang:	Volltext
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