Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

In two studies from teams led by Hiroshi Kawaguchi and Jang-Soo Chun, a role for HIF-2α in osteoarthritis has been uncovered. Along with identifying the molecular mechanism, the teams found that HIF-2α expression is increased in human osteoarthritic tissue, and mice deficient for the protein are pro...

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Veröffentlicht in:	Nature medicine 2010-06, Vol.16 (6), p.678-686
Hauptverfasser:	Saito, Taku, Fukai, Atsushi, Mabuchi, Akihiko, Ikeda, Toshiyuki, Yano, Fumiko, Ohba, Shinsuke, Nishida, Nao, Akune, Toru, Yoshimura, Noriko, Nakagawa, Takumi, Nakamura, Kozo, Tokunaga, Katsushi, Chung, Ung-il, Kawaguchi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2060/2068 631/208/200 692/699/1670/407 Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Endochondral ossification Genetic aspects Genetic regulation Infectious Diseases Metabolic Diseases Molecular Medicine Neurosciences Osteoarthritis Physiological aspects Transcription factors
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