Presynaptic [GABA.sub.A] receptors enhance transmission and LTP induction at hippocampal mossy fiber synapses

Presynaptic [GABA.sub.A] receptors ([GABA.sub.A]Rs) occur at hippocampal mossy fiber synapses. Whether and how they modulate orthodromic signaling to postsynaptic targets is poorly understood. We found that an endogenous neurosteroid that is selective for high-affinity 8 subunit-containing [GABA.sub...

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Veröffentlicht in:	Nature neuroscience 2010-04, Vol.13 (4), p.431
Hauptverfasser:	Ruiz, Arnaud, Campanac, Emilie, Scott, Ricardo S, Rusakov, Dmitri A, Kullmann, Dimitri M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular signal transduction GABA Long-term potentiation Neural transmission Physiological aspects Receptors
Online-Zugang:	Volltext
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