Cytogenetic and antineoplastic effects of modified steroidal alkylators

The aim of this study was to design new potentially antineoplastic agents by combining nitrogen mustard with steroidal skeleton, in an effort to improve specificity and simultaneously to reduce systemic toxicity. The steroidal part is aimed to act as a biological platform enabling the alkylating moi...

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Veröffentlicht in:	Genetic testing and molecular biomarkers 2010-02, Vol.14 (1), p.93-97
Hauptverfasser:	Karapidaki, Irini, Papageorgiou, Athanasios, Geromichalos, George, Fousteris, Manolis, Papaconstadinou, Ioanna, Pairas, George, Koutsourea, Anna, Mourelatos, Denis, Nikolaropoulos, Sotiris, Lialiaris, Theodoros
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating agents Androstanes - chemical synthesis Androstanes - chemistry Androstanes - pharmacology Animals Antineoplastic Agents, Alkylating - chemical synthesis Antineoplastic Agents, Alkylating - chemistry Antineoplastic Agents, Alkylating - pharmacology Care and treatment Cell Proliferation - drug effects Cells, Cultured Chemical properties Drug Design Drug Screening Assays, Antitumor Health aspects Humans In Vitro Techniques Leukemia Leukemia L1210 - drug therapy Leukemia L1210 - genetics Leukemia L1210 - pathology Lymphocytes - cytology Lymphocytes - drug effects Mice Molecular Structure Sister Chromatid Exchange - drug effects
Online-Zugang:	Volltext
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