Inhibition of γ-secretase as a therapeutic intervention for Alzheimer's disease: Prospects, limitations and strategies

Genetic and experimental evidence points to amyloid-beta (Abeta) peptide as the culprit in Alzheimer's disease pathogenesis. This protein fragment abnormally accumulates in the brain cortex and hippocampus of patients with Alzheimer's disease, and self-aggregates to form toxic oligomers ca...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	CNS drugs 2006-01, Vol.20 (5), p.351-372
Hauptverfasser:	EVIN, Geneviève, SERNEE, Marijke Fleur, MASTERS, Colin L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - metabolism Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Endopeptidases - chemistry Endopeptidases - metabolism Enzyme Inhibitors - classification Enzyme Inhibitors - therapeutic use Humans Medical sciences Models, Biological Neurology Neuropharmacology Organic mental disorders. Neuropsychology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Signal Transduction - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!