Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools

To study the effect of mycophenolate mofetil therapy on the pharmacokinetic parameters of a number of antiretroviral drugs, on intracellular pools of deoxycytidine triphosphate (dCTP) and deoxyguanosine triphosphate (dGTP), and on intracellular concentrations of the triphosphate of lamivudine (3TCTP...

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Veröffentlicht in:	Clinical pharmacokinetics 2004-01, Vol.43 (12), p.823-832
Hauptverfasser:	SANKATSING, Sanjay U. C, HAGGARD, Patrick G, HUITEMA, Alwin D. R, SPARIDANS, Rolf W, KEWN, Stephen, CROMMENTUYN, Kristel M. L, LANGE, Joep M. A, BEIJNEN, Jos H, BACK, David J, PRINS, Jan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - metabolism Adult Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Anti-Retroviral Agents - pharmacokinetics Anti-Retroviral Agents - therapeutic use Biological and medical sciences Cytidine Triphosphate - analogs & derivatives Cytidine Triphosphate - pharmacokinetics Deoxycytosine Nucleotides - pharmacokinetics Deoxyguanine Nucleotides - pharmacokinetics Dideoxynucleotides Drug Interactions HIV-1 Humans Immunomodulators Lamivudine - analogs & derivatives Lamivudine - pharmacokinetics Male Medical sciences Metabolic Clearance Rate Middle Aged Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - blood Mycophenolic Acid - pharmacokinetics Mycophenolic Acid - therapeutic use Pharmacology. Drug treatments
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