Drug transfer and metabolism by the human placenta

The major function of the placenta is to transfer nutrients and oxygen from the mother to the foetus and to assist in the removal of waste products from the foetus to the mother. In addition, it plays an important role in the synthesis of hormones, peptides and steroids that are vital for a successf...

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Veröffentlicht in:	Clinical pharmacokinetics 2004-01, Vol.43 (8), p.487-514
Hauptverfasser:	SYME, Michael R, PAXTON, James W, KEELAN, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Transporter, Sub-Family B - classification ATP Binding Cassette Transporter, Sub-Family B - metabolism ATP Binding Cassette Transporter, Sub-Family B - physiology Biological and medical sciences Biological Transport, Active Cytochrome P-450 Enzyme System - classification Cytochrome P-450 Enzyme System - metabolism Cytochrome P-450 Enzyme System - physiology Female General pharmacology Humans Maternal-Fetal Exchange - physiology Medical sciences Pharmaceutical Preparations - metabolism Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Placenta - anatomy & histology Placenta - metabolism Placenta - physiology Pregnancy
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