Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling

Food-induced changes in gastric emptying time, gastric pH and/or intestinal fluid composition may have an impact on the pharmacokinetics of drugs. The aim of this work was to use mathematical models describing physiology in fed and fasted states together with biorelevant solubility and degradation d...

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Veröffentlicht in:	Clinical pharmacokinetics 2006-01, Vol.45 (12), p.1213-1226
Hauptverfasser:	JONES, Hannah M, PARROTT, Neil, OHLENBUSCH, Gerd, LAVE, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Biological and medical sciences Biological Availability Computer Simulation Cross-Over Studies Fasting - physiology Food-Drug Interactions - physiology General pharmacology Humans Hydrophobic and Hydrophilic Interactions Intestinal Absorption - physiology Medical sciences Models, Biological Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Software Solubility
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