TGFβ–SMAD signal transduction: molecular specificity and functional flexibility

Key Points More than 30 mammalian genes comprise the TGFβ superfamily of growth factors. They have important roles in the regulation of cellular functions both in the adult organism and during embryogenesis. Signal duration and signal magnitude are crucial determinants of the outcome of TGFβ superfa...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2007-12, Vol.8 (12), p.970-982
Hauptverfasser:	Schmierer, Bernhard, Hill, Caroline S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Cancer Research Cell Biology Cellular signal transduction Developmental Biology Genetic aspects Genetic regulation Health aspects Life Sciences Physiological aspects review-article Stem Cells Transforming growth factors
Online-Zugang:	Volltext
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