Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation

In the present study, we investigated the in vitro effect of resveratrol (RSVL), a polyphenolic phytoestrogen, on cell proliferation and osteoblastic maturation in human bone marrow-derived mesenchymal stem cell (HBMSC) cultures. RSVL (10 −8–10 −5 M) increased cell growth dose-dependently, as measur...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2007-12, Vol.14 (12), p.806-814
Hauptverfasser:	Dai, Z., Li, Y., Quarles, L.D., Song, T., Pan, W., Zhou, H., Xiao, Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Core Binding Factor Alpha 1 Subunit - genetics Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - enzymology Enzyme Activation ERK1/2 Estrogen receptor Gene Expression Regulation - drug effects Health aspects Humans MAP Kinase Signaling System - drug effects Mesenchymal stem cell Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Osteoblasts - cytology Osteoblasts - drug effects Osteocalcin - genetics P38 MAPK Resveratrol RNA, Messenger - genetics Sp7 Transcription Factor Stem cell research Stilbenes - pharmacology Transcription Factors - genetics
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