Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats
Croton celtidifolius Bailon, commonly known as Sangue–de–Adáve or Pau-Andrade, is a tree found in the Atlantic forest of southern Brazil. It has been popularly used for the treatment of inflammatory and ulcerative disorders. Phytochemical analysis demonstrated the presence of flavonoids and proantho...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2007-02, Vol.14 (2), p.115-122 |
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| creator | Nardi, G.M. Siqueira Junior, J.M. Delle Monache, F. Pizzolatti, M.G. Ckless, K. Ribeiro-do-Valle, R.M. |
| description | Croton celtidifolius Bailon, commonly known as
Sangue–de–Adáve or
Pau-Andrade, is a tree found in the Atlantic forest of southern Brazil. It has been popularly used for the treatment of inflammatory and ulcerative disorders. Phytochemical analysis demonstrated the presence of flavonoids and proanthocyanidins in an ethyl acetate fraction (EAF) from
C. celtidifolius Bailon. In this study, we have evaluated the effects of EAF and its sub-fractions (35 and 63, catechin) on inflammatory (cell migration and plasma extravasation) and oxidative (lipid peroxidation, superoxide dismutase (SOD) activity and superoxide anion production) parameters in carrageenan-induced pleurisy in rats. NO production was also measured by nitrite/nitrate levels. EAF and sub-fraction 63 (63SF) showed anti-inflammatory activity, as indicated by a reduction in plasma extravasation and cell migration (mainly polymorphonuclear leukocytes) to the pleural cavity. Furthermore, EAF treatment decreased the production of superoxide radical anion by cells isolated from the pleural cavity, while it did not affect the nitrite/nitrate levels in exudates. The results show that
C. celtidifolius contains substances with antioxidant and anti-inflammatory activity that, at least in part, act by a modulation of oxidative stress by phenolic compounds. |
| doi_str_mv | 10.1016/j.phymed.2006.03.002 |
| format | Article |
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Sangue–de–Adáve or
Pau-Andrade, is a tree found in the Atlantic forest of southern Brazil. It has been popularly used for the treatment of inflammatory and ulcerative disorders. Phytochemical analysis demonstrated the presence of flavonoids and proanthocyanidins in an ethyl acetate fraction (EAF) from
C. celtidifolius Bailon. In this study, we have evaluated the effects of EAF and its sub-fractions (35 and 63, catechin) on inflammatory (cell migration and plasma extravasation) and oxidative (lipid peroxidation, superoxide dismutase (SOD) activity and superoxide anion production) parameters in carrageenan-induced pleurisy in rats. NO production was also measured by nitrite/nitrate levels. EAF and sub-fraction 63 (63SF) showed anti-inflammatory activity, as indicated by a reduction in plasma extravasation and cell migration (mainly polymorphonuclear leukocytes) to the pleural cavity. Furthermore, EAF treatment decreased the production of superoxide radical anion by cells isolated from the pleural cavity, while it did not affect the nitrite/nitrate levels in exudates. The results show that
C. celtidifolius contains substances with antioxidant and anti-inflammatory activity that, at least in part, act by a modulation of oxidative stress by phenolic compounds.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2006.03.002</identifier><identifier>PMID: 16962304</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antioxidants - administration & dosage ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Carrageenan ; Composition ; Croton ; Croton celtidifolius ; Dose-Response Relationship, Drug ; Drug therapy ; Health aspects ; Inflammation ; Leukemia ; Leukocytes - drug effects ; Leukocytes - metabolism ; Male ; Malondialdehyde - metabolism ; Medicinal plants ; Natural products ; Phytotherapy ; Plant Bark ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Pleurisy - chemically induced ; Pleurisy - prevention & control ; Rats ; Rats, Sprague-Dawley ; Reactive oxygen species ; Rheumatic diseases ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Ulcers</subject><ispartof>Phytomedicine (Stuttgart), 2007-02, Vol.14 (2), p.115-122</ispartof><rights>2006 Elsevier GmbH</rights><rights>COPYRIGHT 2007 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-1df81c9c44b9251f3382b10705c51c7a7bde91618748921deea6f2a1e98c8b053</citedby><cites>FETCH-LOGICAL-c531t-1df81c9c44b9251f3382b10705c51c7a7bde91618748921deea6f2a1e98c8b053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711306000481$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16962304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nardi, G.M.</creatorcontrib><creatorcontrib>Siqueira Junior, J.M.</creatorcontrib><creatorcontrib>Delle Monache, F.</creatorcontrib><creatorcontrib>Pizzolatti, M.G.</creatorcontrib><creatorcontrib>Ckless, K.</creatorcontrib><creatorcontrib>Ribeiro-do-Valle, R.M.</creatorcontrib><title>Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Croton celtidifolius Bailon, commonly known as
Sangue–de–Adáve or
Pau-Andrade, is a tree found in the Atlantic forest of southern Brazil. It has been popularly used for the treatment of inflammatory and ulcerative disorders. Phytochemical analysis demonstrated the presence of flavonoids and proanthocyanidins in an ethyl acetate fraction (EAF) from
C. celtidifolius Bailon. In this study, we have evaluated the effects of EAF and its sub-fractions (35 and 63, catechin) on inflammatory (cell migration and plasma extravasation) and oxidative (lipid peroxidation, superoxide dismutase (SOD) activity and superoxide anion production) parameters in carrageenan-induced pleurisy in rats. NO production was also measured by nitrite/nitrate levels. EAF and sub-fraction 63 (63SF) showed anti-inflammatory activity, as indicated by a reduction in plasma extravasation and cell migration (mainly polymorphonuclear leukocytes) to the pleural cavity. Furthermore, EAF treatment decreased the production of superoxide radical anion by cells isolated from the pleural cavity, while it did not affect the nitrite/nitrate levels in exudates. The results show that
C. celtidifolius contains substances with antioxidant and anti-inflammatory activity that, at least in part, act by a modulation of oxidative stress by phenolic compounds.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Carrageenan</subject><subject>Composition</subject><subject>Croton</subject><subject>Croton celtidifolius</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug therapy</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Leukemia</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medicinal plants</subject><subject>Natural products</subject><subject>Phytotherapy</subject><subject>Plant Bark</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Pleurisy - chemically induced</subject><subject>Pleurisy - prevention & control</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reactive oxygen species</subject><subject>Rheumatic diseases</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Ulcers</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVuLFDEQhYMo7rj6D0QCPndb6fT1RRgHb7Dgi4JvIZ1UxgzdSZNkZOfF327aXgRhkBASTs5XoeoQ8pJByYC1b07l8uMyoy4rgLYEXgJUj8iOtawvYGi-PyY7GOq66BjjN-RZjCcAVg8dPCU3rB3aikO9I7_2Lll_b7V0iUqn8062sM5Mcp5l8uFC0RhUKVJv6BK8Pq93E_xMD8En76jCKVltjZ_sOdJ30k5ZXHUZgjwiOulywcyhpsuE52DjhVpHg0zxOXli5BTxxcN5S759eP_18Km4-_Lx82F_V6iGs1QwbXqmBlXX41A1zHDeVyODDhrVMNXJbtQ4rJ13dT9UTCPK1lSS4dCrfoSG35LXW92jnFDk9nwKUs02KrH_wwHwLruKK64jOgwyN4XGZvkff3nFn5fG2aqrQL0BKvgYAxqxBDvLcBEMxJqqOIktVbGmKoCLnGrGXm3Ych7Xt7_QQ4zZ8HYzYJ7hT4tBRGXR5YnbkLMT2tv___AbbIq2Ag</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Nardi, G.M.</creator><creator>Siqueira Junior, J.M.</creator><creator>Delle Monache, F.</creator><creator>Pizzolatti, M.G.</creator><creator>Ckless, K.</creator><creator>Ribeiro-do-Valle, R.M.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200702</creationdate><title>Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats</title><author>Nardi, G.M. ; Siqueira Junior, J.M. ; Delle Monache, F. ; Pizzolatti, M.G. ; Ckless, K. ; Ribeiro-do-Valle, R.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-1df81c9c44b9251f3382b10705c51c7a7bde91618748921deea6f2a1e98c8b053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Carrageenan</topic><topic>Composition</topic><topic>Croton</topic><topic>Croton celtidifolius</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug therapy</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Leukemia</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medicinal plants</topic><topic>Natural products</topic><topic>Phytotherapy</topic><topic>Plant Bark</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Pleurisy - chemically induced</topic><topic>Pleurisy - prevention & control</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reactive oxygen species</topic><topic>Rheumatic diseases</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nardi, G.M.</creatorcontrib><creatorcontrib>Siqueira Junior, J.M.</creatorcontrib><creatorcontrib>Delle Monache, F.</creatorcontrib><creatorcontrib>Pizzolatti, M.G.</creatorcontrib><creatorcontrib>Ckless, K.</creatorcontrib><creatorcontrib>Ribeiro-do-Valle, R.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nardi, G.M.</au><au>Siqueira Junior, J.M.</au><au>Delle Monache, F.</au><au>Pizzolatti, M.G.</au><au>Ckless, K.</au><au>Ribeiro-do-Valle, R.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2007-02</date><risdate>2007</risdate><volume>14</volume><issue>2</issue><spage>115</spage><epage>122</epage><pages>115-122</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Croton celtidifolius Bailon, commonly known as
Sangue–de–Adáve or
Pau-Andrade, is a tree found in the Atlantic forest of southern Brazil. It has been popularly used for the treatment of inflammatory and ulcerative disorders. Phytochemical analysis demonstrated the presence of flavonoids and proanthocyanidins in an ethyl acetate fraction (EAF) from
C. celtidifolius Bailon. In this study, we have evaluated the effects of EAF and its sub-fractions (35 and 63, catechin) on inflammatory (cell migration and plasma extravasation) and oxidative (lipid peroxidation, superoxide dismutase (SOD) activity and superoxide anion production) parameters in carrageenan-induced pleurisy in rats. NO production was also measured by nitrite/nitrate levels. EAF and sub-fraction 63 (63SF) showed anti-inflammatory activity, as indicated by a reduction in plasma extravasation and cell migration (mainly polymorphonuclear leukocytes) to the pleural cavity. Furthermore, EAF treatment decreased the production of superoxide radical anion by cells isolated from the pleural cavity, while it did not affect the nitrite/nitrate levels in exudates. The results show that
C. celtidifolius contains substances with antioxidant and anti-inflammatory activity that, at least in part, act by a modulation of oxidative stress by phenolic compounds.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>16962304</pmid><doi>10.1016/j.phymed.2006.03.002</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2007-02, Vol.14 (2), p.115-122 |
| issn | 0944-7113 1618-095X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antioxidants - administration & dosage Antioxidants - pharmacology Antioxidants - therapeutic use Carrageenan Composition Croton Croton celtidifolius Dose-Response Relationship, Drug Drug therapy Health aspects Inflammation Leukemia Leukocytes - drug effects Leukocytes - metabolism Male Malondialdehyde - metabolism Medicinal plants Natural products Phytotherapy Plant Bark Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Pleurisy - chemically induced Pleurisy - prevention & control Rats Rats, Sprague-Dawley Reactive oxygen species Rheumatic diseases Superoxide dismutase Superoxide Dismutase - metabolism Ulcers |
| title | Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats |
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