Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in

Acceleration of vascular smooth muscle cell (VSMC) proliferation is closely linked to the pathogenesis of vascular diseases. We, therefore, focused on traditional Japanese herbal medicines (Kampo medicines) used to ameliorate the impairment of microcirculation or blood stasis and screened them for t...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2006-05, Vol.13 (5), p.334-342
Hauptverfasser:	Tanabe, H., Suzuki, H., Nagatsu, A., Mizukami, H., Ogihara, Y., Inoue, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Berberine - analogs & derivatives Berberine - pharmacology Blood circulation disorders Cell Cycle - drug effects Cell Proliferation - drug effects Chromatography, High Pressure Liquid - methods Coptis Coptis - chemistry Coptis rhizoma Coptisine Drug therapy Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Growth inhibition Health aspects HeLa Cells Humans Inhibitory Concentration 50 Kampo medicine Male Medicine, Kampo Melanoma, Experimental Mice Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Rats Rats, Sprague-Dawley Rhizome - chemistry Vascular smooth muscle cell
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