Defective suppressor function in CD[4.sup.+]CD[25.sup.+] T-cells from patients with type 1 diabetes

Type 1 diabetes is a T-cell-mediated disease that is associated with loss of immunological tolerance to self-antigens. The mechanisms involved in maintenance of peripheral tolerance include a specialized subset of regulatory T-cells (Treg) within the CD[4.sup.+]CD[25.sup.+] T-cell population, but th...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2005-01, Vol.54 (1), p.92
Hauptverfasser:	Lindley, Shelley, Dayan, Colin M, Bishop, Amanda, Roep, Bart O, Peakman, Mark, Tree, Timothy I.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity Physiological aspects T cells Type 1 diabetes
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