Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain

Transient interactions of platelet-receptor glycoprotein Ibα (GpIbα) and the plasma protein von Willebrand factor (VWF) reduce platelet velocity at sites of vascular damage and play a role in haemostasis and thrombosis. Here we present structures of the GpIbα amino-terminal domain and its complex wi...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-08, Vol.297 (5584), p.1176-1179
Hauptverfasser:	Huizinga, Eric G., Tsuji, Shizuko, Roland A. P. Romijn, Schiphorst, Marion E., de Groot, Philip G., Sixma, Jan J., Gros, Piet
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood coagulation. Blood cells Blood platelets Coagulation factors Crystal structure Disulfides Drug interactions Electron density Electrostatics Fundamental and applied biological sciences. Psychology Glycoproteins Hematologic and hematopoietic diseases Ligands Medical sciences Molecular and cellular biology Molecules Platelet diseases and coagulopathies Platelets Stereo
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