Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes
Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes Hilary Hoey , MA, MD 1 , Henk-Jan Aanstoot , MD, PHD 2 , Francesco Chiarelli , MD 3 , Denis Daneman , MD 4 , Thomas Danne , MD 5 , Harry Dorchy , MD, PHD 6 , Michael Fitzgerald , MD 7 , Patrick...
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Veröffentlicht in: | Diabetes care 2001-11, Vol.24 (11), p.1923-1928 |
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container_title | Diabetes care |
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creator | HOEY, Hilary AANSTOOT, Henk-Jan HOUGAARD, Philip KAPRIO, Eero KOCOVA, Mirjana LYNGGAARD, Helle MARTUL, Pedro MATSUURA, Nobuo MCGEE, Hannah M MORTENSEN, Henrik B ROBERTSON, Kenneth SCHOENLE, Eugen CHIARELLI, Francesco SOVIK, Oddmund SWIFT, Peter TSOU, Rosa Maria VANELLI, Maurizio AMAN, Jan DANEMAN, Denis DANNE, Thomas DORCHY, Harry FITZGERALD, Michael GARANDEAU, Patrick GREENE, Stephen HOLL, Reinhard |
description | Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes
Hilary Hoey , MA, MD 1 ,
Henk-Jan Aanstoot , MD, PHD 2 ,
Francesco Chiarelli , MD 3 ,
Denis Daneman , MD 4 ,
Thomas Danne , MD 5 ,
Harry Dorchy , MD, PHD 6 ,
Michael Fitzgerald , MD 7 ,
Patrick Garandeau , MD 8 ,
Stephen Greene , MD, DC 9 ,
Reinhard Holl , MD 10 ,
Philip Hougaard , PHD 11 ,
Eero Kaprio , MD, DR MED CHIR 12 ,
Mirjana Kocova , MD 13 ,
Helle Lynggaard , MSC 14 ,
Pedro Martul , MD, PHD 15 ,
Nobuo Matsuura , MD 16 ,
Hannah M. McGee , BA, PHD 17 ,
Henrik B. Mortensen , MD, DR MED SCI 18 ,
Kenneth Robertson , MD 19 ,
Eugen Schoenle , MD 20 ,
Oddmund Sovik , MD 21 ,
Peter Swift , MD 22 ,
Rosa Maria Tsou , MD 23 ,
Maurizio Vanelli , MD 24 ,
Jan Åman , MD, PHD 25 and
For the Hvidøre Study Group on Childhood Diabetes
1 Department of Paediatrics, Trinity College, National Children’s Hospital, Dublin, Ireland
2 Ijsselland Hospital, Capelle, the Netherlands
3 Pediatric University Clinic, Chieti, Italy
4 Hospital for Sick Children, University of Toronto, Toronto, Canada
5 Charité, Humboldt University, Berlin, Germany
6 University Children’s Hospital, Queen Fabiola, Brussels, Belgium
7 Department of Psychiatry, Trinity College, Dublin, Ireland
8 Institut Saint Pierre, Montpellier, France
9 University of Dundee, Dundee, United Kingdom
10 University of Ulm, Ulm, Germany
11 Novo Nordisk, Bagsværd, Denmark
12 Peijas Hospital, Peijas, Finland
13 Pediatric Clinic-Skopje, Skopje, Republic of Macedonia
14 Novo Nordisk, Bagsværd, Denmark
15 Endocrinologia Pediatrica Hospital De Cruces, Cruces, Spain
16 Kitasato University School of Medicine, Kitasato, Japan
17 Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
18 Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark
19 Royal Hospital for Sick Children, Glasgow, United Kingdom
20 University Children’s Hospital, Zurich, Switzerland
21 Haukeland Hospital, Bergen, Norway
22 Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom
23 Hospital S. Joao, Porto, Portugal
24 Department of Paediatrics, University of Parma, Italy
25 Örebro Medical Centre Hospital, Örebro, Sweden
Abstract
OBJECTIVE —It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence
on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large international
cohort of adolescen |
doi_str_mv | 10.2337/diacare.24.11.1923 |
format | Article |
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Hilary Hoey , MA, MD 1 ,
Henk-Jan Aanstoot , MD, PHD 2 ,
Francesco Chiarelli , MD 3 ,
Denis Daneman , MD 4 ,
Thomas Danne , MD 5 ,
Harry Dorchy , MD, PHD 6 ,
Michael Fitzgerald , MD 7 ,
Patrick Garandeau , MD 8 ,
Stephen Greene , MD, DC 9 ,
Reinhard Holl , MD 10 ,
Philip Hougaard , PHD 11 ,
Eero Kaprio , MD, DR MED CHIR 12 ,
Mirjana Kocova , MD 13 ,
Helle Lynggaard , MSC 14 ,
Pedro Martul , MD, PHD 15 ,
Nobuo Matsuura , MD 16 ,
Hannah M. McGee , BA, PHD 17 ,
Henrik B. Mortensen , MD, DR MED SCI 18 ,
Kenneth Robertson , MD 19 ,
Eugen Schoenle , MD 20 ,
Oddmund Sovik , MD 21 ,
Peter Swift , MD 22 ,
Rosa Maria Tsou , MD 23 ,
Maurizio Vanelli , MD 24 ,
Jan Åman , MD, PHD 25 and
For the Hvidøre Study Group on Childhood Diabetes
1 Department of Paediatrics, Trinity College, National Children’s Hospital, Dublin, Ireland
2 Ijsselland Hospital, Capelle, the Netherlands
3 Pediatric University Clinic, Chieti, Italy
4 Hospital for Sick Children, University of Toronto, Toronto, Canada
5 Charité, Humboldt University, Berlin, Germany
6 University Children’s Hospital, Queen Fabiola, Brussels, Belgium
7 Department of Psychiatry, Trinity College, Dublin, Ireland
8 Institut Saint Pierre, Montpellier, France
9 University of Dundee, Dundee, United Kingdom
10 University of Ulm, Ulm, Germany
11 Novo Nordisk, Bagsværd, Denmark
12 Peijas Hospital, Peijas, Finland
13 Pediatric Clinic-Skopje, Skopje, Republic of Macedonia
14 Novo Nordisk, Bagsværd, Denmark
15 Endocrinologia Pediatrica Hospital De Cruces, Cruces, Spain
16 Kitasato University School of Medicine, Kitasato, Japan
17 Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
18 Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark
19 Royal Hospital for Sick Children, Glasgow, United Kingdom
20 University Children’s Hospital, Zurich, Switzerland
21 Haukeland Hospital, Bergen, Norway
22 Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom
23 Hospital S. Joao, Porto, Portugal
24 Department of Paediatrics, University of Parma, Italy
25 Örebro Medical Centre Hospital, Örebro, Sweden
Abstract
OBJECTIVE —It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence
on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large international
cohort of adolescents with diabetes and their families.
RESEARCH DESIGN AND METHODS —The study involved 2,101 adolescents, aged 10–18 years, from 21 centers in 17 countries in Europe, Japan, and North America.
Clinical and demographic data were collected from March through August 1998. HbA 1c was analyzed centrally (normal range 4.4–6.3%; mean 5.4%). Adolescent QOL was assessed by a previously developed Diabetes
Quality of Life (DQOL) questionnaire for adolescents, measuring the impact of diabetes, worries about diabetes, satisfaction
with life, and health perception. Parents and health professionals assessed family burden using newly constructed questionnaires.
RESULTS —Mean HbA 1c was 8.7% (range 4.8–17.4). Lower HbA 1c was associated with lower impact ( P < 0.0001), fewer worries ( P < 0.05), greater satisfaction ( P < 0.0001), and better health perception ( P < 0.0001) for adolescents. Girls showed increased worries ( P < 0.01), less satisfaction, and poorer health perception ( P < 0.01) earlier than boys. Parent and health professional perceptions of burden decreased with age of adolescent ( P < 0.0001). Patients from ethnic minorities had poorer scores for impact ( P < 0.0001), worries ( P < 0.05), and health perception ( P < 0.01). There was no correlation between adolescent and parent or between adolescent and professional scores.
CONCLUSIONS —In a multiple regression model, lower HbA 1c was significantly associated with better adolescent-rated QOL on all four subscales and with lower perceived family burden
as assessed by parents and health professionals.
DQOL, Diabetes Quality of Life
QOL, quality of life
Footnotes
Address correspondence and reprint requests to Professor Hilary M.C.V. Hoey, Department of Paediatrics, Trinity College, National
Children’s Hospital, Tallaght, Dublin, 24, Ireland. E-mail: hhoeydge{at}indigo.ie .
Received for publication 15 December 2000 and accepted in revised form 22 June 2001.
The parent and health professional questionnaires used in this study are available from H.H.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.]]></description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/diacare.24.11.1923</identifier><identifier>PMID: 11679458</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adolescent ; Biological and medical sciences ; Biomarkers ; Blood Glucose - metabolism ; Care and treatment ; Child ; Cross-Cultural Comparison ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes Mellitus, Type 1 - psychology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Europe ; Female ; Glycated Hemoglobin A - metabolism ; Health aspects ; Health Status ; Humans ; International ; Japan ; Male ; Management. Various non-drug treatments. Langerhans islet grafts ; Medical sciences ; Metabolic regulation ; Metabolism ; Normal Distribution ; North America ; Physiological aspects ; Quality of Life ; Reference Values ; Regression Analysis ; Sex Factors ; Surveys and Questionnaires ; Teenagers ; Type 1 diabetes ; Youth</subject><ispartof>Diabetes care, 2001-11, Vol.24 (11), p.1923-1928</ispartof><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Diabetes Association</rights><rights>Copyright American Diabetes Association Nov 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-5177b9a77c96fd56a77735c6803623564d9ac2072ee2f5759464c57b7f643ff73</citedby><cites>FETCH-LOGICAL-c511t-5177b9a77c96fd56a77735c6803623564d9ac2072ee2f5759464c57b7f643ff73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14151376$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11679458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOEY, Hilary</creatorcontrib><creatorcontrib>AANSTOOT, Henk-Jan</creatorcontrib><creatorcontrib>HOUGAARD, Philip</creatorcontrib><creatorcontrib>KAPRIO, Eero</creatorcontrib><creatorcontrib>KOCOVA, Mirjana</creatorcontrib><creatorcontrib>LYNGGAARD, Helle</creatorcontrib><creatorcontrib>MARTUL, Pedro</creatorcontrib><creatorcontrib>MATSUURA, Nobuo</creatorcontrib><creatorcontrib>MCGEE, Hannah M</creatorcontrib><creatorcontrib>MORTENSEN, Henrik B</creatorcontrib><creatorcontrib>ROBERTSON, Kenneth</creatorcontrib><creatorcontrib>SCHOENLE, Eugen</creatorcontrib><creatorcontrib>CHIARELLI, Francesco</creatorcontrib><creatorcontrib>SOVIK, Oddmund</creatorcontrib><creatorcontrib>SWIFT, Peter</creatorcontrib><creatorcontrib>TSOU, Rosa Maria</creatorcontrib><creatorcontrib>VANELLI, Maurizio</creatorcontrib><creatorcontrib>AMAN, Jan</creatorcontrib><creatorcontrib>DANEMAN, Denis</creatorcontrib><creatorcontrib>DANNE, Thomas</creatorcontrib><creatorcontrib>DORCHY, Harry</creatorcontrib><creatorcontrib>FITZGERALD, Michael</creatorcontrib><creatorcontrib>GARANDEAU, Patrick</creatorcontrib><creatorcontrib>GREENE, Stephen</creatorcontrib><creatorcontrib>HOLL, Reinhard</creatorcontrib><creatorcontrib>For the Hvidøre Study Group on Childhood Diabetes</creatorcontrib><title>Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description><![CDATA[Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes
Hilary Hoey , MA, MD 1 ,
Henk-Jan Aanstoot , MD, PHD 2 ,
Francesco Chiarelli , MD 3 ,
Denis Daneman , MD 4 ,
Thomas Danne , MD 5 ,
Harry Dorchy , MD, PHD 6 ,
Michael Fitzgerald , MD 7 ,
Patrick Garandeau , MD 8 ,
Stephen Greene , MD, DC 9 ,
Reinhard Holl , MD 10 ,
Philip Hougaard , PHD 11 ,
Eero Kaprio , MD, DR MED CHIR 12 ,
Mirjana Kocova , MD 13 ,
Helle Lynggaard , MSC 14 ,
Pedro Martul , MD, PHD 15 ,
Nobuo Matsuura , MD 16 ,
Hannah M. McGee , BA, PHD 17 ,
Henrik B. Mortensen , MD, DR MED SCI 18 ,
Kenneth Robertson , MD 19 ,
Eugen Schoenle , MD 20 ,
Oddmund Sovik , MD 21 ,
Peter Swift , MD 22 ,
Rosa Maria Tsou , MD 23 ,
Maurizio Vanelli , MD 24 ,
Jan Åman , MD, PHD 25 and
For the Hvidøre Study Group on Childhood Diabetes
1 Department of Paediatrics, Trinity College, National Children’s Hospital, Dublin, Ireland
2 Ijsselland Hospital, Capelle, the Netherlands
3 Pediatric University Clinic, Chieti, Italy
4 Hospital for Sick Children, University of Toronto, Toronto, Canada
5 Charité, Humboldt University, Berlin, Germany
6 University Children’s Hospital, Queen Fabiola, Brussels, Belgium
7 Department of Psychiatry, Trinity College, Dublin, Ireland
8 Institut Saint Pierre, Montpellier, France
9 University of Dundee, Dundee, United Kingdom
10 University of Ulm, Ulm, Germany
11 Novo Nordisk, Bagsværd, Denmark
12 Peijas Hospital, Peijas, Finland
13 Pediatric Clinic-Skopje, Skopje, Republic of Macedonia
14 Novo Nordisk, Bagsværd, Denmark
15 Endocrinologia Pediatrica Hospital De Cruces, Cruces, Spain
16 Kitasato University School of Medicine, Kitasato, Japan
17 Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
18 Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark
19 Royal Hospital for Sick Children, Glasgow, United Kingdom
20 University Children’s Hospital, Zurich, Switzerland
21 Haukeland Hospital, Bergen, Norway
22 Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom
23 Hospital S. Joao, Porto, Portugal
24 Department of Paediatrics, University of Parma, Italy
25 Örebro Medical Centre Hospital, Örebro, Sweden
Abstract
OBJECTIVE —It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence
on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large international
cohort of adolescents with diabetes and their families.
RESEARCH DESIGN AND METHODS —The study involved 2,101 adolescents, aged 10–18 years, from 21 centers in 17 countries in Europe, Japan, and North America.
Clinical and demographic data were collected from March through August 1998. HbA 1c was analyzed centrally (normal range 4.4–6.3%; mean 5.4%). Adolescent QOL was assessed by a previously developed Diabetes
Quality of Life (DQOL) questionnaire for adolescents, measuring the impact of diabetes, worries about diabetes, satisfaction
with life, and health perception. Parents and health professionals assessed family burden using newly constructed questionnaires.
RESULTS —Mean HbA 1c was 8.7% (range 4.8–17.4). Lower HbA 1c was associated with lower impact ( P < 0.0001), fewer worries ( P < 0.05), greater satisfaction ( P < 0.0001), and better health perception ( P < 0.0001) for adolescents. Girls showed increased worries ( P < 0.01), less satisfaction, and poorer health perception ( P < 0.01) earlier than boys. Parent and health professional perceptions of burden decreased with age of adolescent ( P < 0.0001). Patients from ethnic minorities had poorer scores for impact ( P < 0.0001), worries ( P < 0.05), and health perception ( P < 0.01). There was no correlation between adolescent and parent or between adolescent and professional scores.
CONCLUSIONS —In a multiple regression model, lower HbA 1c was significantly associated with better adolescent-rated QOL on all four subscales and with lower perceived family burden
as assessed by parents and health professionals.
DQOL, Diabetes Quality of Life
QOL, quality of life
Footnotes
Address correspondence and reprint requests to Professor Hilary M.C.V. Hoey, Department of Paediatrics, Trinity College, National
Children’s Hospital, Tallaght, Dublin, 24, Ireland. E-mail: hhoeydge{at}indigo.ie .
Received for publication 15 December 2000 and accepted in revised form 22 June 2001.
The parent and health professional questionnaires used in this study are available from H.H.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.]]></description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood Glucose - metabolism</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Cross-Cultural Comparison</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes Mellitus, Type 1 - psychology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Europe</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Health aspects</subject><subject>Health Status</subject><subject>Humans</subject><subject>International</subject><subject>Japan</subject><subject>Male</subject><subject>Management. Various non-drug treatments. Langerhans islet grafts</subject><subject>Medical sciences</subject><subject>Metabolic regulation</subject><subject>Metabolism</subject><subject>Normal Distribution</subject><subject>North America</subject><subject>Physiological aspects</subject><subject>Quality of Life</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Sex Factors</subject><subject>Surveys and Questionnaires</subject><subject>Teenagers</subject><subject>Type 1 diabetes</subject><subject>Youth</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0V2LEzEUBuBBFLeu_gEvJAh6407N52RyWauuCxURVrwMaeakTZlOapJB-u_NMgMLUnKREJ6Tc8hbVa8JXlLG5MfOG2siLClfErIkirIn1YIoJmohePu0WmDCVS2UolfVi5QOGGPO2_Z5dUVIIxUX7aI63IbQoe-QzTb03qJ1GHIMPbpLaJVSsN5k6NBvn_foE-QMEf0cTe_zGQWHNt4B8gOiNwQTtOpCD8nCkNNUcH8-ASLoszdbyJBeVs-c6RO8mvfr6tfXL_frb_Xmx-3derWprSAk14JIuVVGSqsa14mmnCQTtmkxaygTDe-UsRRLCkCdkELxhlsht9I1nDkn2XX1fnr3FMOfEVLWR1_G6nszQBiTlpRShTEt8O1_8BDGOJTZNKUMcywlLuhmQjvTg_aDCzkau4MBounDAM6X61UZri1_wAuvL_CyOjh6e8nTydsYUorg9Cn6o4lnTbB-SFnPKWvKNSH6IeVS9GYefNweoXssmWMt4N0MTLKmd9EM1qdHx4kgTDbFfZjc3u_2f33p0s1hXWr7D6dMvFE</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>HOEY, Hilary</creator><creator>AANSTOOT, Henk-Jan</creator><creator>HOUGAARD, Philip</creator><creator>KAPRIO, Eero</creator><creator>KOCOVA, Mirjana</creator><creator>LYNGGAARD, Helle</creator><creator>MARTUL, Pedro</creator><creator>MATSUURA, Nobuo</creator><creator>MCGEE, Hannah M</creator><creator>MORTENSEN, Henrik B</creator><creator>ROBERTSON, Kenneth</creator><creator>SCHOENLE, Eugen</creator><creator>CHIARELLI, Francesco</creator><creator>SOVIK, Oddmund</creator><creator>SWIFT, Peter</creator><creator>TSOU, Rosa Maria</creator><creator>VANELLI, Maurizio</creator><creator>AMAN, Jan</creator><creator>DANEMAN, Denis</creator><creator>DANNE, Thomas</creator><creator>DORCHY, Harry</creator><creator>FITZGERALD, Michael</creator><creator>GARANDEAU, Patrick</creator><creator>GREENE, Stephen</creator><creator>HOLL, Reinhard</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes</title><author>HOEY, Hilary ; AANSTOOT, Henk-Jan ; HOUGAARD, Philip ; KAPRIO, Eero ; KOCOVA, Mirjana ; LYNGGAARD, Helle ; MARTUL, Pedro ; MATSUURA, Nobuo ; MCGEE, Hannah M ; MORTENSEN, Henrik B ; ROBERTSON, Kenneth ; SCHOENLE, Eugen ; CHIARELLI, Francesco ; SOVIK, Oddmund ; SWIFT, Peter ; TSOU, Rosa Maria ; VANELLI, Maurizio ; AMAN, Jan ; DANEMAN, Denis ; DANNE, Thomas ; DORCHY, Harry ; FITZGERALD, Michael ; GARANDEAU, Patrick ; GREENE, Stephen ; HOLL, Reinhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-5177b9a77c96fd56a77735c6803623564d9ac2072ee2f5759464c57b7f643ff73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood Glucose - metabolism</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Cross-Cultural Comparison</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes Mellitus, Type 1 - psychology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Europe</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Health aspects</topic><topic>Health Status</topic><topic>Humans</topic><topic>International</topic><topic>Japan</topic><topic>Male</topic><topic>Management. Various non-drug treatments. Langerhans islet grafts</topic><topic>Medical sciences</topic><topic>Metabolic regulation</topic><topic>Metabolism</topic><topic>Normal Distribution</topic><topic>North America</topic><topic>Physiological aspects</topic><topic>Quality of Life</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Sex Factors</topic><topic>Surveys and Questionnaires</topic><topic>Teenagers</topic><topic>Type 1 diabetes</topic><topic>Youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOEY, Hilary</creatorcontrib><creatorcontrib>AANSTOOT, Henk-Jan</creatorcontrib><creatorcontrib>HOUGAARD, Philip</creatorcontrib><creatorcontrib>KAPRIO, Eero</creatorcontrib><creatorcontrib>KOCOVA, Mirjana</creatorcontrib><creatorcontrib>LYNGGAARD, Helle</creatorcontrib><creatorcontrib>MARTUL, Pedro</creatorcontrib><creatorcontrib>MATSUURA, Nobuo</creatorcontrib><creatorcontrib>MCGEE, Hannah M</creatorcontrib><creatorcontrib>MORTENSEN, Henrik B</creatorcontrib><creatorcontrib>ROBERTSON, Kenneth</creatorcontrib><creatorcontrib>SCHOENLE, Eugen</creatorcontrib><creatorcontrib>CHIARELLI, Francesco</creatorcontrib><creatorcontrib>SOVIK, Oddmund</creatorcontrib><creatorcontrib>SWIFT, Peter</creatorcontrib><creatorcontrib>TSOU, Rosa Maria</creatorcontrib><creatorcontrib>VANELLI, Maurizio</creatorcontrib><creatorcontrib>AMAN, Jan</creatorcontrib><creatorcontrib>DANEMAN, Denis</creatorcontrib><creatorcontrib>DANNE, Thomas</creatorcontrib><creatorcontrib>DORCHY, Harry</creatorcontrib><creatorcontrib>FITZGERALD, Michael</creatorcontrib><creatorcontrib>GARANDEAU, Patrick</creatorcontrib><creatorcontrib>GREENE, Stephen</creatorcontrib><creatorcontrib>HOLL, Reinhard</creatorcontrib><creatorcontrib>For the Hvidøre Study Group on Childhood Diabetes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOEY, Hilary</au><au>AANSTOOT, Henk-Jan</au><au>HOUGAARD, Philip</au><au>KAPRIO, Eero</au><au>KOCOVA, Mirjana</au><au>LYNGGAARD, Helle</au><au>MARTUL, Pedro</au><au>MATSUURA, Nobuo</au><au>MCGEE, Hannah M</au><au>MORTENSEN, Henrik B</au><au>ROBERTSON, Kenneth</au><au>SCHOENLE, Eugen</au><au>CHIARELLI, Francesco</au><au>SOVIK, Oddmund</au><au>SWIFT, Peter</au><au>TSOU, Rosa Maria</au><au>VANELLI, Maurizio</au><au>AMAN, Jan</au><au>DANEMAN, Denis</au><au>DANNE, Thomas</au><au>DORCHY, Harry</au><au>FITZGERALD, Michael</au><au>GARANDEAU, Patrick</au><au>GREENE, Stephen</au><au>HOLL, Reinhard</au><aucorp>For the Hvidøre Study Group on Childhood Diabetes</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>24</volume><issue>11</issue><spage>1923</spage><epage>1928</epage><pages>1923-1928</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract><![CDATA[Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes
Hilary Hoey , MA, MD 1 ,
Henk-Jan Aanstoot , MD, PHD 2 ,
Francesco Chiarelli , MD 3 ,
Denis Daneman , MD 4 ,
Thomas Danne , MD 5 ,
Harry Dorchy , MD, PHD 6 ,
Michael Fitzgerald , MD 7 ,
Patrick Garandeau , MD 8 ,
Stephen Greene , MD, DC 9 ,
Reinhard Holl , MD 10 ,
Philip Hougaard , PHD 11 ,
Eero Kaprio , MD, DR MED CHIR 12 ,
Mirjana Kocova , MD 13 ,
Helle Lynggaard , MSC 14 ,
Pedro Martul , MD, PHD 15 ,
Nobuo Matsuura , MD 16 ,
Hannah M. McGee , BA, PHD 17 ,
Henrik B. Mortensen , MD, DR MED SCI 18 ,
Kenneth Robertson , MD 19 ,
Eugen Schoenle , MD 20 ,
Oddmund Sovik , MD 21 ,
Peter Swift , MD 22 ,
Rosa Maria Tsou , MD 23 ,
Maurizio Vanelli , MD 24 ,
Jan Åman , MD, PHD 25 and
For the Hvidøre Study Group on Childhood Diabetes
1 Department of Paediatrics, Trinity College, National Children’s Hospital, Dublin, Ireland
2 Ijsselland Hospital, Capelle, the Netherlands
3 Pediatric University Clinic, Chieti, Italy
4 Hospital for Sick Children, University of Toronto, Toronto, Canada
5 Charité, Humboldt University, Berlin, Germany
6 University Children’s Hospital, Queen Fabiola, Brussels, Belgium
7 Department of Psychiatry, Trinity College, Dublin, Ireland
8 Institut Saint Pierre, Montpellier, France
9 University of Dundee, Dundee, United Kingdom
10 University of Ulm, Ulm, Germany
11 Novo Nordisk, Bagsværd, Denmark
12 Peijas Hospital, Peijas, Finland
13 Pediatric Clinic-Skopje, Skopje, Republic of Macedonia
14 Novo Nordisk, Bagsværd, Denmark
15 Endocrinologia Pediatrica Hospital De Cruces, Cruces, Spain
16 Kitasato University School of Medicine, Kitasato, Japan
17 Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland
18 Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark
19 Royal Hospital for Sick Children, Glasgow, United Kingdom
20 University Children’s Hospital, Zurich, Switzerland
21 Haukeland Hospital, Bergen, Norway
22 Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom
23 Hospital S. Joao, Porto, Portugal
24 Department of Paediatrics, University of Parma, Italy
25 Örebro Medical Centre Hospital, Örebro, Sweden
Abstract
OBJECTIVE —It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence
on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large international
cohort of adolescents with diabetes and their families.
RESEARCH DESIGN AND METHODS —The study involved 2,101 adolescents, aged 10–18 years, from 21 centers in 17 countries in Europe, Japan, and North America.
Clinical and demographic data were collected from March through August 1998. HbA 1c was analyzed centrally (normal range 4.4–6.3%; mean 5.4%). Adolescent QOL was assessed by a previously developed Diabetes
Quality of Life (DQOL) questionnaire for adolescents, measuring the impact of diabetes, worries about diabetes, satisfaction
with life, and health perception. Parents and health professionals assessed family burden using newly constructed questionnaires.
RESULTS —Mean HbA 1c was 8.7% (range 4.8–17.4). Lower HbA 1c was associated with lower impact ( P < 0.0001), fewer worries ( P < 0.05), greater satisfaction ( P < 0.0001), and better health perception ( P < 0.0001) for adolescents. Girls showed increased worries ( P < 0.01), less satisfaction, and poorer health perception ( P < 0.01) earlier than boys. Parent and health professional perceptions of burden decreased with age of adolescent ( P < 0.0001). Patients from ethnic minorities had poorer scores for impact ( P < 0.0001), worries ( P < 0.05), and health perception ( P < 0.01). There was no correlation between adolescent and parent or between adolescent and professional scores.
CONCLUSIONS —In a multiple regression model, lower HbA 1c was significantly associated with better adolescent-rated QOL on all four subscales and with lower perceived family burden
as assessed by parents and health professionals.
DQOL, Diabetes Quality of Life
QOL, quality of life
Footnotes
Address correspondence and reprint requests to Professor Hilary M.C.V. Hoey, Department of Paediatrics, Trinity College, National
Children’s Hospital, Tallaght, Dublin, 24, Ireland. E-mail: hhoeydge{at}indigo.ie .
Received for publication 15 December 2000 and accepted in revised form 22 June 2001.
The parent and health professional questionnaires used in this study are available from H.H.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.]]></abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>11679458</pmid><doi>10.2337/diacare.24.11.1923</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Biological and medical sciences Biomarkers Blood Glucose - metabolism Care and treatment Child Cross-Cultural Comparison Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 1 - psychology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Europe Female Glycated Hemoglobin A - metabolism Health aspects Health Status Humans International Japan Male Management. Various non-drug treatments. Langerhans islet grafts Medical sciences Metabolic regulation Metabolism Normal Distribution North America Physiological aspects Quality of Life Reference Values Regression Analysis Sex Factors Surveys and Questionnaires Teenagers Type 1 diabetes Youth |
title | Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes |
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