Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes

Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes Hilary Hoey , MA, MD 1 , Henk-Jan Aanstoot , MD, PHD 2 , Francesco Chiarelli , MD 3 , Denis Daneman , MD 4 , Thomas Danne , MD 5 , Harry Dorchy , MD, PHD 6 , Michael Fitzgerald , MD 7 , Patrick...

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Veröffentlicht in:Diabetes care 2001-11, Vol.24 (11), p.1923-1928
Hauptverfasser: HOEY, Hilary, AANSTOOT, Henk-Jan, HOUGAARD, Philip, KAPRIO, Eero, KOCOVA, Mirjana, LYNGGAARD, Helle, MARTUL, Pedro, MATSUURA, Nobuo, MCGEE, Hannah M, MORTENSEN, Henrik B, ROBERTSON, Kenneth, SCHOENLE, Eugen, CHIARELLI, Francesco, SOVIK, Oddmund, SWIFT, Peter, TSOU, Rosa Maria, VANELLI, Maurizio, AMAN, Jan, DANEMAN, Denis, DANNE, Thomas, DORCHY, Harry, FITZGERALD, Michael, GARANDEAU, Patrick, GREENE, Stephen, HOLL, Reinhard
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container_end_page 1928
container_issue 11
container_start_page 1923
container_title Diabetes care
container_volume 24
creator HOEY, Hilary
AANSTOOT, Henk-Jan
HOUGAARD, Philip
KAPRIO, Eero
KOCOVA, Mirjana
LYNGGAARD, Helle
MARTUL, Pedro
MATSUURA, Nobuo
MCGEE, Hannah M
MORTENSEN, Henrik B
ROBERTSON, Kenneth
SCHOENLE, Eugen
CHIARELLI, Francesco
SOVIK, Oddmund
SWIFT, Peter
TSOU, Rosa Maria
VANELLI, Maurizio
AMAN, Jan
DANEMAN, Denis
DANNE, Thomas
DORCHY, Harry
FITZGERALD, Michael
GARANDEAU, Patrick
GREENE, Stephen
HOLL, Reinhard
description Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes Hilary Hoey , MA, MD 1 , Henk-Jan Aanstoot , MD, PHD 2 , Francesco Chiarelli , MD 3 , Denis Daneman , MD 4 , Thomas Danne , MD 5 , Harry Dorchy , MD, PHD 6 , Michael Fitzgerald , MD 7 , Patrick Garandeau , MD 8 , Stephen Greene , MD, DC 9 , Reinhard Holl , MD 10 , Philip Hougaard , PHD 11 , Eero Kaprio , MD, DR MED CHIR 12 , Mirjana Kocova , MD 13 , Helle Lynggaard , MSC 14 , Pedro Martul , MD, PHD 15 , Nobuo Matsuura , MD 16 , Hannah M. McGee , BA, PHD 17 , Henrik B. Mortensen , MD, DR MED SCI 18 , Kenneth Robertson , MD 19 , Eugen Schoenle , MD 20 , Oddmund Sovik , MD 21 , Peter Swift , MD 22 , Rosa Maria Tsou , MD 23 , Maurizio Vanelli , MD 24 , Jan Åman , MD, PHD 25 and For the Hvidøre Study Group on Childhood Diabetes 1 Department of Paediatrics, Trinity College, National Children’s Hospital, Dublin, Ireland 2 Ijsselland Hospital, Capelle, the Netherlands 3 Pediatric University Clinic, Chieti, Italy 4 Hospital for Sick Children, University of Toronto, Toronto, Canada 5 Charité, Humboldt University, Berlin, Germany 6 University Children’s Hospital, Queen Fabiola, Brussels, Belgium 7 Department of Psychiatry, Trinity College, Dublin, Ireland 8 Institut Saint Pierre, Montpellier, France 9 University of Dundee, Dundee, United Kingdom 10 University of Ulm, Ulm, Germany 11 Novo Nordisk, Bagsværd, Denmark 12 Peijas Hospital, Peijas, Finland 13 Pediatric Clinic-Skopje, Skopje, Republic of Macedonia 14 Novo Nordisk, Bagsværd, Denmark 15 Endocrinologia Pediatrica Hospital De Cruces, Cruces, Spain 16 Kitasato University School of Medicine, Kitasato, Japan 17 Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland 18 Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark 19 Royal Hospital for Sick Children, Glasgow, United Kingdom 20 University Children’s Hospital, Zurich, Switzerland 21 Haukeland Hospital, Bergen, Norway 22 Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom 23 Hospital S. Joao, Porto, Portugal 24 Department of Paediatrics, University of Parma, Italy 25 Örebro Medical Centre Hospital, Örebro, Sweden Abstract OBJECTIVE —It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large international cohort of adolescen
doi_str_mv 10.2337/diacare.24.11.1923
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McGee , BA, PHD 17 , Henrik B. Mortensen , MD, DR MED SCI 18 , Kenneth Robertson , MD 19 , Eugen Schoenle , MD 20 , Oddmund Sovik , MD 21 , Peter Swift , MD 22 , Rosa Maria Tsou , MD 23 , Maurizio Vanelli , MD 24 , Jan Åman , MD, PHD 25 and For the Hvidøre Study Group on Childhood Diabetes 1 Department of Paediatrics, Trinity College, National Children’s Hospital, Dublin, Ireland 2 Ijsselland Hospital, Capelle, the Netherlands 3 Pediatric University Clinic, Chieti, Italy 4 Hospital for Sick Children, University of Toronto, Toronto, Canada 5 Charité, Humboldt University, Berlin, Germany 6 University Children’s Hospital, Queen Fabiola, Brussels, Belgium 7 Department of Psychiatry, Trinity College, Dublin, Ireland 8 Institut Saint Pierre, Montpellier, France 9 University of Dundee, Dundee, United Kingdom 10 University of Ulm, Ulm, Germany 11 Novo Nordisk, Bagsværd, Denmark 12 Peijas Hospital, Peijas, Finland 13 Pediatric Clinic-Skopje, Skopje, Republic of Macedonia 14 Novo Nordisk, Bagsværd, Denmark 15 Endocrinologia Pediatrica Hospital De Cruces, Cruces, Spain 16 Kitasato University School of Medicine, Kitasato, Japan 17 Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland 18 Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark 19 Royal Hospital for Sick Children, Glasgow, United Kingdom 20 University Children’s Hospital, Zurich, Switzerland 21 Haukeland Hospital, Bergen, Norway 22 Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom 23 Hospital S. Joao, Porto, Portugal 24 Department of Paediatrics, University of Parma, Italy 25 Örebro Medical Centre Hospital, Örebro, Sweden Abstract OBJECTIVE —It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large international cohort of adolescents with diabetes and their families. RESEARCH DESIGN AND METHODS —The study involved 2,101 adolescents, aged 10–18 years, from 21 centers in 17 countries in Europe, Japan, and North America. Clinical and demographic data were collected from March through August 1998. HbA 1c was analyzed centrally (normal range 4.4–6.3%; mean 5.4%). Adolescent QOL was assessed by a previously developed Diabetes Quality of Life (DQOL) questionnaire for adolescents, measuring the impact of diabetes, worries about diabetes, satisfaction with life, and health perception. Parents and health professionals assessed family burden using newly constructed questionnaires. RESULTS —Mean HbA 1c was 8.7% (range 4.8–17.4). Lower HbA 1c was associated with lower impact ( P < 0.0001), fewer worries ( P < 0.05), greater satisfaction ( P < 0.0001), and better health perception ( P < 0.0001) for adolescents. Girls showed increased worries ( P < 0.01), less satisfaction, and poorer health perception ( P < 0.01) earlier than boys. Parent and health professional perceptions of burden decreased with age of adolescent ( P < 0.0001). Patients from ethnic minorities had poorer scores for impact ( P < 0.0001), worries ( P < 0.05), and health perception ( P < 0.01). There was no correlation between adolescent and parent or between adolescent and professional scores. CONCLUSIONS —In a multiple regression model, lower HbA 1c was significantly associated with better adolescent-rated QOL on all four subscales and with lower perceived family burden as assessed by parents and health professionals. DQOL, Diabetes Quality of Life QOL, quality of life Footnotes Address correspondence and reprint requests to Professor Hilary M.C.V. Hoey, Department of Paediatrics, Trinity College, National Children’s Hospital, Tallaght, Dublin, 24, Ireland. E-mail: hhoeydge{at}indigo.ie . Received for publication 15 December 2000 and accepted in revised form 22 June 2001. The parent and health professional questionnaires used in this study are available from H.H. A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.]]></description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/diacare.24.11.1923</identifier><identifier>PMID: 11679458</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adolescent ; Biological and medical sciences ; Biomarkers ; Blood Glucose - metabolism ; Care and treatment ; Child ; Cross-Cultural Comparison ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes Mellitus, Type 1 - psychology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Europe ; Female ; Glycated Hemoglobin A - metabolism ; Health aspects ; Health Status ; Humans ; International ; Japan ; Male ; Management. Various non-drug treatments. Langerhans islet grafts ; Medical sciences ; Metabolic regulation ; Metabolism ; Normal Distribution ; North America ; Physiological aspects ; Quality of Life ; Reference Values ; Regression Analysis ; Sex Factors ; Surveys and Questionnaires ; Teenagers ; Type 1 diabetes ; Youth</subject><ispartof>Diabetes care, 2001-11, Vol.24 (11), p.1923-1928</ispartof><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Diabetes Association</rights><rights>Copyright American Diabetes Association Nov 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-5177b9a77c96fd56a77735c6803623564d9ac2072ee2f5759464c57b7f643ff73</citedby><cites>FETCH-LOGICAL-c511t-5177b9a77c96fd56a77735c6803623564d9ac2072ee2f5759464c57b7f643ff73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=14151376$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11679458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOEY, Hilary</creatorcontrib><creatorcontrib>AANSTOOT, Henk-Jan</creatorcontrib><creatorcontrib>HOUGAARD, Philip</creatorcontrib><creatorcontrib>KAPRIO, Eero</creatorcontrib><creatorcontrib>KOCOVA, Mirjana</creatorcontrib><creatorcontrib>LYNGGAARD, Helle</creatorcontrib><creatorcontrib>MARTUL, Pedro</creatorcontrib><creatorcontrib>MATSUURA, Nobuo</creatorcontrib><creatorcontrib>MCGEE, Hannah M</creatorcontrib><creatorcontrib>MORTENSEN, Henrik B</creatorcontrib><creatorcontrib>ROBERTSON, Kenneth</creatorcontrib><creatorcontrib>SCHOENLE, Eugen</creatorcontrib><creatorcontrib>CHIARELLI, Francesco</creatorcontrib><creatorcontrib>SOVIK, Oddmund</creatorcontrib><creatorcontrib>SWIFT, Peter</creatorcontrib><creatorcontrib>TSOU, Rosa Maria</creatorcontrib><creatorcontrib>VANELLI, Maurizio</creatorcontrib><creatorcontrib>AMAN, Jan</creatorcontrib><creatorcontrib>DANEMAN, Denis</creatorcontrib><creatorcontrib>DANNE, Thomas</creatorcontrib><creatorcontrib>DORCHY, Harry</creatorcontrib><creatorcontrib>FITZGERALD, Michael</creatorcontrib><creatorcontrib>GARANDEAU, Patrick</creatorcontrib><creatorcontrib>GREENE, Stephen</creatorcontrib><creatorcontrib>HOLL, Reinhard</creatorcontrib><creatorcontrib>For the Hvidøre Study Group on Childhood Diabetes</creatorcontrib><title>Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description><![CDATA[Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes Hilary Hoey , MA, MD 1 , Henk-Jan Aanstoot , MD, PHD 2 , Francesco Chiarelli , MD 3 , Denis Daneman , MD 4 , Thomas Danne , MD 5 , Harry Dorchy , MD, PHD 6 , Michael Fitzgerald , MD 7 , Patrick Garandeau , MD 8 , Stephen Greene , MD, DC 9 , Reinhard Holl , MD 10 , Philip Hougaard , PHD 11 , Eero Kaprio , MD, DR MED CHIR 12 , Mirjana Kocova , MD 13 , Helle Lynggaard , MSC 14 , Pedro Martul , MD, PHD 15 , Nobuo Matsuura , MD 16 , Hannah M. McGee , BA, PHD 17 , Henrik B. Mortensen , MD, DR MED SCI 18 , Kenneth Robertson , MD 19 , Eugen Schoenle , MD 20 , Oddmund Sovik , MD 21 , Peter Swift , MD 22 , Rosa Maria Tsou , MD 23 , Maurizio Vanelli , MD 24 , Jan Åman , MD, PHD 25 and For the Hvidøre Study Group on Childhood Diabetes 1 Department of Paediatrics, Trinity College, National Children’s Hospital, Dublin, Ireland 2 Ijsselland Hospital, Capelle, the Netherlands 3 Pediatric University Clinic, Chieti, Italy 4 Hospital for Sick Children, University of Toronto, Toronto, Canada 5 Charité, Humboldt University, Berlin, Germany 6 University Children’s Hospital, Queen Fabiola, Brussels, Belgium 7 Department of Psychiatry, Trinity College, Dublin, Ireland 8 Institut Saint Pierre, Montpellier, France 9 University of Dundee, Dundee, United Kingdom 10 University of Ulm, Ulm, Germany 11 Novo Nordisk, Bagsværd, Denmark 12 Peijas Hospital, Peijas, Finland 13 Pediatric Clinic-Skopje, Skopje, Republic of Macedonia 14 Novo Nordisk, Bagsværd, Denmark 15 Endocrinologia Pediatrica Hospital De Cruces, Cruces, Spain 16 Kitasato University School of Medicine, Kitasato, Japan 17 Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland 18 Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark 19 Royal Hospital for Sick Children, Glasgow, United Kingdom 20 University Children’s Hospital, Zurich, Switzerland 21 Haukeland Hospital, Bergen, Norway 22 Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom 23 Hospital S. Joao, Porto, Portugal 24 Department of Paediatrics, University of Parma, Italy 25 Örebro Medical Centre Hospital, Örebro, Sweden Abstract OBJECTIVE —It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large international cohort of adolescents with diabetes and their families. RESEARCH DESIGN AND METHODS —The study involved 2,101 adolescents, aged 10–18 years, from 21 centers in 17 countries in Europe, Japan, and North America. Clinical and demographic data were collected from March through August 1998. HbA 1c was analyzed centrally (normal range 4.4–6.3%; mean 5.4%). Adolescent QOL was assessed by a previously developed Diabetes Quality of Life (DQOL) questionnaire for adolescents, measuring the impact of diabetes, worries about diabetes, satisfaction with life, and health perception. Parents and health professionals assessed family burden using newly constructed questionnaires. RESULTS —Mean HbA 1c was 8.7% (range 4.8–17.4). Lower HbA 1c was associated with lower impact ( P < 0.0001), fewer worries ( P < 0.05), greater satisfaction ( P < 0.0001), and better health perception ( P < 0.0001) for adolescents. Girls showed increased worries ( P < 0.01), less satisfaction, and poorer health perception ( P < 0.01) earlier than boys. Parent and health professional perceptions of burden decreased with age of adolescent ( P < 0.0001). Patients from ethnic minorities had poorer scores for impact ( P < 0.0001), worries ( P < 0.05), and health perception ( P < 0.01). There was no correlation between adolescent and parent or between adolescent and professional scores. CONCLUSIONS —In a multiple regression model, lower HbA 1c was significantly associated with better adolescent-rated QOL on all four subscales and with lower perceived family burden as assessed by parents and health professionals. DQOL, Diabetes Quality of Life QOL, quality of life Footnotes Address correspondence and reprint requests to Professor Hilary M.C.V. Hoey, Department of Paediatrics, Trinity College, National Children’s Hospital, Tallaght, Dublin, 24, Ireland. E-mail: hhoeydge{at}indigo.ie . Received for publication 15 December 2000 and accepted in revised form 22 June 2001. The parent and health professional questionnaires used in this study are available from H.H. A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.]]></description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood Glucose - metabolism</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Cross-Cultural Comparison</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes Mellitus, Type 1 - psychology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Europe</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Health aspects</subject><subject>Health Status</subject><subject>Humans</subject><subject>International</subject><subject>Japan</subject><subject>Male</subject><subject>Management. Various non-drug treatments. Langerhans islet grafts</subject><subject>Medical sciences</subject><subject>Metabolic regulation</subject><subject>Metabolism</subject><subject>Normal Distribution</subject><subject>North America</subject><subject>Physiological aspects</subject><subject>Quality of Life</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Sex Factors</subject><subject>Surveys and Questionnaires</subject><subject>Teenagers</subject><subject>Type 1 diabetes</subject><subject>Youth</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0V2LEzEUBuBBFLeu_gEvJAh6407N52RyWauuCxURVrwMaeakTZlOapJB-u_NMgMLUnKREJ6Tc8hbVa8JXlLG5MfOG2siLClfErIkirIn1YIoJmohePu0WmDCVS2UolfVi5QOGGPO2_Z5dUVIIxUX7aI63IbQoe-QzTb03qJ1GHIMPbpLaJVSsN5k6NBvn_foE-QMEf0cTe_zGQWHNt4B8gOiNwQTtOpCD8nCkNNUcH8-ASLoszdbyJBeVs-c6RO8mvfr6tfXL_frb_Xmx-3derWprSAk14JIuVVGSqsa14mmnCQTtmkxaygTDe-UsRRLCkCdkELxhlsht9I1nDkn2XX1fnr3FMOfEVLWR1_G6nszQBiTlpRShTEt8O1_8BDGOJTZNKUMcywlLuhmQjvTg_aDCzkau4MBounDAM6X61UZri1_wAuvL_CyOjh6e8nTydsYUorg9Cn6o4lnTbB-SFnPKWvKNSH6IeVS9GYefNweoXssmWMt4N0MTLKmd9EM1qdHx4kgTDbFfZjc3u_2f33p0s1hXWr7D6dMvFE</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>HOEY, Hilary</creator><creator>AANSTOOT, Henk-Jan</creator><creator>HOUGAARD, Philip</creator><creator>KAPRIO, Eero</creator><creator>KOCOVA, Mirjana</creator><creator>LYNGGAARD, Helle</creator><creator>MARTUL, Pedro</creator><creator>MATSUURA, Nobuo</creator><creator>MCGEE, Hannah M</creator><creator>MORTENSEN, Henrik B</creator><creator>ROBERTSON, Kenneth</creator><creator>SCHOENLE, Eugen</creator><creator>CHIARELLI, Francesco</creator><creator>SOVIK, Oddmund</creator><creator>SWIFT, Peter</creator><creator>TSOU, Rosa Maria</creator><creator>VANELLI, Maurizio</creator><creator>AMAN, Jan</creator><creator>DANEMAN, Denis</creator><creator>DANNE, Thomas</creator><creator>DORCHY, Harry</creator><creator>FITZGERALD, Michael</creator><creator>GARANDEAU, Patrick</creator><creator>GREENE, Stephen</creator><creator>HOLL, Reinhard</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes</title><author>HOEY, Hilary ; AANSTOOT, Henk-Jan ; HOUGAARD, Philip ; KAPRIO, Eero ; KOCOVA, Mirjana ; LYNGGAARD, Helle ; MARTUL, Pedro ; MATSUURA, Nobuo ; MCGEE, Hannah M ; MORTENSEN, Henrik B ; ROBERTSON, Kenneth ; SCHOENLE, Eugen ; CHIARELLI, Francesco ; SOVIK, Oddmund ; SWIFT, Peter ; TSOU, Rosa Maria ; VANELLI, Maurizio ; AMAN, Jan ; DANEMAN, Denis ; DANNE, Thomas ; DORCHY, Harry ; FITZGERALD, Michael ; GARANDEAU, Patrick ; GREENE, Stephen ; HOLL, Reinhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-5177b9a77c96fd56a77735c6803623564d9ac2072ee2f5759464c57b7f643ff73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood Glucose - metabolism</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Cross-Cultural Comparison</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes Mellitus, Type 1 - psychology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Europe</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Health aspects</topic><topic>Health Status</topic><topic>Humans</topic><topic>International</topic><topic>Japan</topic><topic>Male</topic><topic>Management. Various non-drug treatments. Langerhans islet grafts</topic><topic>Medical sciences</topic><topic>Metabolic regulation</topic><topic>Metabolism</topic><topic>Normal Distribution</topic><topic>North America</topic><topic>Physiological aspects</topic><topic>Quality of Life</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Sex Factors</topic><topic>Surveys and Questionnaires</topic><topic>Teenagers</topic><topic>Type 1 diabetes</topic><topic>Youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOEY, Hilary</creatorcontrib><creatorcontrib>AANSTOOT, Henk-Jan</creatorcontrib><creatorcontrib>HOUGAARD, Philip</creatorcontrib><creatorcontrib>KAPRIO, Eero</creatorcontrib><creatorcontrib>KOCOVA, Mirjana</creatorcontrib><creatorcontrib>LYNGGAARD, Helle</creatorcontrib><creatorcontrib>MARTUL, Pedro</creatorcontrib><creatorcontrib>MATSUURA, Nobuo</creatorcontrib><creatorcontrib>MCGEE, Hannah M</creatorcontrib><creatorcontrib>MORTENSEN, Henrik B</creatorcontrib><creatorcontrib>ROBERTSON, Kenneth</creatorcontrib><creatorcontrib>SCHOENLE, Eugen</creatorcontrib><creatorcontrib>CHIARELLI, Francesco</creatorcontrib><creatorcontrib>SOVIK, Oddmund</creatorcontrib><creatorcontrib>SWIFT, Peter</creatorcontrib><creatorcontrib>TSOU, Rosa Maria</creatorcontrib><creatorcontrib>VANELLI, Maurizio</creatorcontrib><creatorcontrib>AMAN, Jan</creatorcontrib><creatorcontrib>DANEMAN, Denis</creatorcontrib><creatorcontrib>DANNE, Thomas</creatorcontrib><creatorcontrib>DORCHY, Harry</creatorcontrib><creatorcontrib>FITZGERALD, Michael</creatorcontrib><creatorcontrib>GARANDEAU, Patrick</creatorcontrib><creatorcontrib>GREENE, Stephen</creatorcontrib><creatorcontrib>HOLL, Reinhard</creatorcontrib><creatorcontrib>For the Hvidøre Study Group on Childhood Diabetes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; 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Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOEY, Hilary</au><au>AANSTOOT, Henk-Jan</au><au>HOUGAARD, Philip</au><au>KAPRIO, Eero</au><au>KOCOVA, Mirjana</au><au>LYNGGAARD, Helle</au><au>MARTUL, Pedro</au><au>MATSUURA, Nobuo</au><au>MCGEE, Hannah M</au><au>MORTENSEN, Henrik B</au><au>ROBERTSON, Kenneth</au><au>SCHOENLE, Eugen</au><au>CHIARELLI, Francesco</au><au>SOVIK, Oddmund</au><au>SWIFT, Peter</au><au>TSOU, Rosa Maria</au><au>VANELLI, Maurizio</au><au>AMAN, Jan</au><au>DANEMAN, Denis</au><au>DANNE, Thomas</au><au>DORCHY, Harry</au><au>FITZGERALD, Michael</au><au>GARANDEAU, Patrick</au><au>GREENE, Stephen</au><au>HOLL, Reinhard</au><aucorp>For the Hvidøre Study Group on Childhood Diabetes</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>24</volume><issue>11</issue><spage>1923</spage><epage>1928</epage><pages>1923-1928</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract><![CDATA[Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes Hilary Hoey , MA, MD 1 , Henk-Jan Aanstoot , MD, PHD 2 , Francesco Chiarelli , MD 3 , Denis Daneman , MD 4 , Thomas Danne , MD 5 , Harry Dorchy , MD, PHD 6 , Michael Fitzgerald , MD 7 , Patrick Garandeau , MD 8 , Stephen Greene , MD, DC 9 , Reinhard Holl , MD 10 , Philip Hougaard , PHD 11 , Eero Kaprio , MD, DR MED CHIR 12 , Mirjana Kocova , MD 13 , Helle Lynggaard , MSC 14 , Pedro Martul , MD, PHD 15 , Nobuo Matsuura , MD 16 , Hannah M. McGee , BA, PHD 17 , Henrik B. Mortensen , MD, DR MED SCI 18 , Kenneth Robertson , MD 19 , Eugen Schoenle , MD 20 , Oddmund Sovik , MD 21 , Peter Swift , MD 22 , Rosa Maria Tsou , MD 23 , Maurizio Vanelli , MD 24 , Jan Åman , MD, PHD 25 and For the Hvidøre Study Group on Childhood Diabetes 1 Department of Paediatrics, Trinity College, National Children’s Hospital, Dublin, Ireland 2 Ijsselland Hospital, Capelle, the Netherlands 3 Pediatric University Clinic, Chieti, Italy 4 Hospital for Sick Children, University of Toronto, Toronto, Canada 5 Charité, Humboldt University, Berlin, Germany 6 University Children’s Hospital, Queen Fabiola, Brussels, Belgium 7 Department of Psychiatry, Trinity College, Dublin, Ireland 8 Institut Saint Pierre, Montpellier, France 9 University of Dundee, Dundee, United Kingdom 10 University of Ulm, Ulm, Germany 11 Novo Nordisk, Bagsværd, Denmark 12 Peijas Hospital, Peijas, Finland 13 Pediatric Clinic-Skopje, Skopje, Republic of Macedonia 14 Novo Nordisk, Bagsværd, Denmark 15 Endocrinologia Pediatrica Hospital De Cruces, Cruces, Spain 16 Kitasato University School of Medicine, Kitasato, Japan 17 Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland 18 Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark 19 Royal Hospital for Sick Children, Glasgow, United Kingdom 20 University Children’s Hospital, Zurich, Switzerland 21 Haukeland Hospital, Bergen, Norway 22 Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom 23 Hospital S. Joao, Porto, Portugal 24 Department of Paediatrics, University of Parma, Italy 25 Örebro Medical Centre Hospital, Örebro, Sweden Abstract OBJECTIVE —It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large international cohort of adolescents with diabetes and their families. RESEARCH DESIGN AND METHODS —The study involved 2,101 adolescents, aged 10–18 years, from 21 centers in 17 countries in Europe, Japan, and North America. Clinical and demographic data were collected from March through August 1998. HbA 1c was analyzed centrally (normal range 4.4–6.3%; mean 5.4%). Adolescent QOL was assessed by a previously developed Diabetes Quality of Life (DQOL) questionnaire for adolescents, measuring the impact of diabetes, worries about diabetes, satisfaction with life, and health perception. Parents and health professionals assessed family burden using newly constructed questionnaires. RESULTS —Mean HbA 1c was 8.7% (range 4.8–17.4). Lower HbA 1c was associated with lower impact ( P < 0.0001), fewer worries ( P < 0.05), greater satisfaction ( P < 0.0001), and better health perception ( P < 0.0001) for adolescents. Girls showed increased worries ( P < 0.01), less satisfaction, and poorer health perception ( P < 0.01) earlier than boys. Parent and health professional perceptions of burden decreased with age of adolescent ( P < 0.0001). Patients from ethnic minorities had poorer scores for impact ( P < 0.0001), worries ( P < 0.05), and health perception ( P < 0.01). There was no correlation between adolescent and parent or between adolescent and professional scores. CONCLUSIONS —In a multiple regression model, lower HbA 1c was significantly associated with better adolescent-rated QOL on all four subscales and with lower perceived family burden as assessed by parents and health professionals. DQOL, Diabetes Quality of Life QOL, quality of life Footnotes Address correspondence and reprint requests to Professor Hilary M.C.V. Hoey, Department of Paediatrics, Trinity College, National Children’s Hospital, Tallaght, Dublin, 24, Ireland. E-mail: hhoeydge{at}indigo.ie . Received for publication 15 December 2000 and accepted in revised form 22 June 2001. The parent and health professional questionnaires used in this study are available from H.H. A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.]]></abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>11679458</pmid><doi>10.2337/diacare.24.11.1923</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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language eng
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source MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects Adolescent
Biological and medical sciences
Biomarkers
Blood Glucose - metabolism
Care and treatment
Child
Cross-Cultural Comparison
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - physiopathology
Diabetes Mellitus, Type 1 - psychology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Europe
Female
Glycated Hemoglobin A - metabolism
Health aspects
Health Status
Humans
International
Japan
Male
Management. Various non-drug treatments. Langerhans islet grafts
Medical sciences
Metabolic regulation
Metabolism
Normal Distribution
North America
Physiological aspects
Quality of Life
Reference Values
Regression Analysis
Sex Factors
Surveys and Questionnaires
Teenagers
Type 1 diabetes
Youth
title Good Metabolic Control Is Associated With Better Quality of Life in 2,101 Adolescents With Type 1 Diabetes
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