Multi-component supramolecular synthesis of spirooxindoles catalyzed by β-cyclodextrin in water

Multi-component supramolecular synthesis of spirooxindoles catalyzed by β-cyclodextrin in water

A neutral and efficient one-pot three-component aqueous-phase synthesis is developed for various spirooxindole derivatives from isatin, malononitrile, and 1,3-dicarbonyl compounds in high yields by supramolecular catalysis involving β-cyclodextrin. The β-cyclodextrin can be recovered and reused a nu...

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Veröffentlicht in:Canadian journal of chemistry 2009-12, Vol.87 (12), p.1704-1707
Hauptverfasser: Sridhar, Regati, Srinivas, Boga, Madhav, Bandaru, Reddy, Vutukuri Prakash, Nageswar, Yadavalli Venkata Durga, Rao, Kakulapati Rama
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Chemical properties
Chemical synthesis
Cyclodextrins
Indole
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Zusammenfassung:A neutral and efficient one-pot three-component aqueous-phase synthesis is developed for various spirooxindole derivatives from isatin, malononitrile, and 1,3-dicarbonyl compounds in high yields by supramolecular catalysis involving β-cyclodextrin. The β-cyclodextrin can be recovered and reused a number of times without any loss of activity.
ISSN:0008-4042
1480-3291
DOI:10.1139/V09-137