Unique [CD14.sup.+] intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

Intestinal macrophages play a central role in regulation of immune responses against commensal bacteria. In general, intestinal macrophages lack the expression of innate-immune receptor CD14 and do not produce proinflammatory cytokines against commensal bacteria. In this study, we identified what we...

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Veröffentlicht in:	The Journal of clinical investigation 2008-06, Vol.118 (6), p.2269
Hauptverfasser:	Kamada, Nobuhiko, Hisamatsu, Tadakazu, Okamoto, Susumu, Chinen, Hiroshi, Kobayashi, Taku, Sato, Toshiro, Sakuraba, Atsushi, Kitazume, Mina T, Sugita, Akira, Koganei, Kazutaka, Akagawa, Kiyoko S, Hibi, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Crohn's disease Diagnosis Health aspects Inflammation Macrophages Risk factors
Online-Zugang:	Volltext
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