ATP and sulfonylurea sensitivity of mutant ATP-sensitive [K.sup.+] channels in neonatal diabetes implications for pharmacogenomic therapy

The prediction that overactivity of the pancreatic ATP-sensitive [K.sup.+] channel ([K.sub.ATP] channel) underlies reduced insulin secretion and causes a diabetic phenotype in humans has recently been borne out by genetic studies implicating "activating" mutations in the Kir6.2 subunit of...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2005-09, Vol.54 (9), p.2645
Hauptverfasser:	Koster, Joseph C, Remedi, Maria S, Dao, Crystal, Nichols, Colin G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Analysis ATP (Adenosine triphosphate) Diabetes in children Gene mutation Gene mutations Genetic aspects Infants (Newborn) Juvenile diabetes Medical examination Newborn infants Observations Pancreatic beta cells
Online-Zugang:	Volltext
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