A novel insulin analog with unique properties: [Lys.sup.B3], [Glu.sup.B29] insulin induces prominent activation of insulin receptor substrate 2, but marginal phosphorylation of insulin receptor substrate 1

The potentially enhanced mitogenic activity of insulin analogs represents a safety risk that requires detailed analysis of new analogs considered for therapeutic applications. We assessed the signaling properties and mitogenic potency of two novel rapid-acting insulin analogs, [Lys.sup.B3],[Glu.sup....

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2003-09, Vol.52 (9), p.2227
Hauptverfasser:	Rakatzi, Irini, Ramrath, Stefanie, Ledwig, Daniela, Dransfeld, Olaf, Bartels, Thomas, Seipke, Gerhard, Eckel, Jurgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood glucose Blood sugar Diabetes Diabetes mellitus Insulin Physiological aspects
Online-Zugang:	Volltext
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