Differential Expression of Ki-67 and P27 in Cholesteatoma Compared to Skin Tissue Predicts the Prognosis of Adult Acquired Cholesteatoma
The aim of this study was to compare the differential Ki-67 and p27 staining properties of acquired cholesteatoma in adult patients for prognostic analysis. Forty-two adult patients with acquired cholesteatoma were enrolled. The cholesteatoma and matched meatal skin tissues of the patients were immu...
Gespeichert in:
| Veröffentlicht in: | Journal of International Advanced Otology 2021-07, Vol.17 (4), p.306-312 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 312 |
|---|---|
| container_issue | 4 |
| container_start_page | 306 |
| container_title | Journal of International Advanced Otology |
| container_volume | 17 |
| creator | Turkili, Serkan Gorur, Kemal Ismi, Onur Serinsoz Linke, Ebru Vaysioglu, Yusuf Ozcan, Cengiz |
| description | The aim of this study was to compare the differential Ki-67 and p27 staining properties of acquired cholesteatoma in adult patients for prognostic analysis.
Forty-two adult patients with acquired cholesteatoma were enrolled. The cholesteatoma and matched meatal skin tissues of the patients were immunostained with Ki-67 and p27 antibodies. Canal wall down mastoidectomy was performed in all patients. The differential staining properties--positive staining in the cholesteatoma and negative staining in the skin tissue (C+S-), negative staining in the cholesteatoma and positive staining in the skin tissue(C-S+)--were compared for bone erosion scores (BES), stage, and recurrence rates.
Isolated findings in the cholesteatoma tissues, without matching with the skin tissues, demonstrated that stage and recurrence rates were not related to findings in the cholesteatoma tissues (P > .05). However, C+S- for Ki-67 and C-S+ for p27 are risk factors for worse prognosis including advanced stage (P < .001 for Ki-67 and P = .008 for p27), BES values (P < .001 for Ki-67 and P = .001 for p27), and recurrence rates (P < .001 for Ki-67 and P = .037 for p27).
This is the first paper assessing the cholesteatoma prognosis according to the differential Ki-67 and p27 staining properties of cholesteatoma and healthy skin tissues. Cellular proliferation rate in the cholesteatoma is important but insufficient by itself for predicting the prognosis of cholesteatoma patients. Patients having lower basal levels of cellular proliferation rate and higher cellular activity in the cholesteatoma tissue are prone to worse prognosis with increased stage, recurrence rates, and degree of bone erosion. |
| doi_str_mv | 10.5152/iao.2021.9453 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_gale_infotraccpiq_670808050</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A670808050</galeid><doaj_id>oai_doaj_org_article_5f2f11b864c94c15a987ea134b12ade1</doaj_id><sourcerecordid>A670808050</sourcerecordid><originalsourceid>FETCH-LOGICAL-c643t-b3d895de254c14aff105944fe2e4baee90713e5a845a542c06e6a70f42e5e773</originalsourceid><addsrcrecordid>eNqNk81v0zAUwCMEYtPYkSuy4DIOKf7MxwWpKgOqTVBpvVuO89x6JHFrJ2j8B_zZOHSMBu2AfEj8_Hs_Oy9-SfKS4Jkggr6zys0opmRWcsGeJKeU8CJlBcmfHr2fJOch2ArzLONYFPR5csI4w6UQ-DT5-cEaAx663qoGXd7tPETYdcgZdGXTLEeqq9GK5sh2aLF1DYQeVO9ahRau3SkPNeoduvkWl9c2hAHQKsas7gPqt-PEbToXbBiF83poejTX-8GOeRPdi-SZUU2A8_vnWbL-eLlefE6vv35aLubXqc4469OK1UUpaqCCa8KVMQSLknMDFHilAEqcEwZCFVwowanGGWQqx4ZTEJDn7CxZHrS1U7dy522r_A_plJW_A85vpPK91Q1IYaghpCoyrsu4mVBlkYMijFeEqhpIdL0_uHZD1UKtYxG9aibS6Upnt3LjvsuizAXHZRRc3Au82w-xFLK1QUPTqA7cECQVQjCeFWI895t_0Fs3-C5WaqSKeBkoZ3-pjYofYDvj4r56lMp5luMiDoEj9foRSu_sXh5Ds0egOGporXYdGBvjE-vbSUJkerjrN2oIQV6tlv_NLm--TNn0wGrvQvBgHgpMsBy7QMYukGMXyLELIv_q-K880H_uPPsFUtn-lA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2558152243</pqid></control><display><type>article</type><title>Differential Expression of Ki-67 and P27 in Cholesteatoma Compared to Skin Tissue Predicts the Prognosis of Adult Acquired Cholesteatoma</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Turkili, Serkan ; Gorur, Kemal ; Ismi, Onur ; Serinsoz Linke, Ebru ; Vaysioglu, Yusuf ; Ozcan, Cengiz</creator><creatorcontrib>Turkili, Serkan ; Gorur, Kemal ; Ismi, Onur ; Serinsoz Linke, Ebru ; Vaysioglu, Yusuf ; Ozcan, Cengiz ; Deparment of Medical Pathology, Pathology and Molecular Diagnostic Institution, Augsburg, Germany ; Clinic of Otorhinolaryngology, Mersin State Hospital, Mersin, Turkey ; Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey</creatorcontrib><description>The aim of this study was to compare the differential Ki-67 and p27 staining properties of acquired cholesteatoma in adult patients for prognostic analysis.
Forty-two adult patients with acquired cholesteatoma were enrolled. The cholesteatoma and matched meatal skin tissues of the patients were immunostained with Ki-67 and p27 antibodies. Canal wall down mastoidectomy was performed in all patients. The differential staining properties--positive staining in the cholesteatoma and negative staining in the skin tissue (C+S-), negative staining in the cholesteatoma and positive staining in the skin tissue(C-S+)--were compared for bone erosion scores (BES), stage, and recurrence rates.
Isolated findings in the cholesteatoma tissues, without matching with the skin tissues, demonstrated that stage and recurrence rates were not related to findings in the cholesteatoma tissues (P > .05). However, C+S- for Ki-67 and C-S+ for p27 are risk factors for worse prognosis including advanced stage (P < .001 for Ki-67 and P = .008 for p27), BES values (P < .001 for Ki-67 and P = .001 for p27), and recurrence rates (P < .001 for Ki-67 and P = .037 for p27).
This is the first paper assessing the cholesteatoma prognosis according to the differential Ki-67 and p27 staining properties of cholesteatoma and healthy skin tissues. Cellular proliferation rate in the cholesteatoma is important but insufficient by itself for predicting the prognosis of cholesteatoma patients. Patients having lower basal levels of cellular proliferation rate and higher cellular activity in the cholesteatoma tissue are prone to worse prognosis with increased stage, recurrence rates, and degree of bone erosion.</description><identifier>ISSN: 2148-3817</identifier><identifier>ISSN: 1308-7649</identifier><identifier>EISSN: 2148-3817</identifier><identifier>DOI: 10.5152/iao.2021.9453</identifier><identifier>PMID: 34309550</identifier><language>eng</language><publisher>Turkey: AVES</publisher><subject>Adult ; Adults ; Antibodies ; Cell cycle ; Cholesteatoma ; Cholesteatoma, Middle Ear - surgery ; Comparative analysis ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclin-dependent kinases ; Humans ; Ki-67 Antigen ; Labeling ; Mastoidectomy ; Medical research ; Medicine, Experimental ; Original ; Pathogenesis ; Patients ; Prognosis ; Recurrence ; Skin ; Statistical analysis ; Surgery</subject><ispartof>Journal of International Advanced Otology, 2021-07, Vol.17 (4), p.306-312</ispartof><rights>COPYRIGHT 2021 AVES</rights><rights>Copyright Mediterranean Society for Otology and Audiology Jul 2021</rights><rights>2021 authors 2021 authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c643t-b3d895de254c14aff105944fe2e4baee90713e5a845a542c06e6a70f42e5e773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975409/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975409/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34309550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turkili, Serkan</creatorcontrib><creatorcontrib>Gorur, Kemal</creatorcontrib><creatorcontrib>Ismi, Onur</creatorcontrib><creatorcontrib>Serinsoz Linke, Ebru</creatorcontrib><creatorcontrib>Vaysioglu, Yusuf</creatorcontrib><creatorcontrib>Ozcan, Cengiz</creatorcontrib><creatorcontrib>Deparment of Medical Pathology, Pathology and Molecular Diagnostic Institution, Augsburg, Germany</creatorcontrib><creatorcontrib>Clinic of Otorhinolaryngology, Mersin State Hospital, Mersin, Turkey</creatorcontrib><creatorcontrib>Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey</creatorcontrib><title>Differential Expression of Ki-67 and P27 in Cholesteatoma Compared to Skin Tissue Predicts the Prognosis of Adult Acquired Cholesteatoma</title><title>Journal of International Advanced Otology</title><addtitle>J Int Adv Otol</addtitle><description>The aim of this study was to compare the differential Ki-67 and p27 staining properties of acquired cholesteatoma in adult patients for prognostic analysis.
Forty-two adult patients with acquired cholesteatoma were enrolled. The cholesteatoma and matched meatal skin tissues of the patients were immunostained with Ki-67 and p27 antibodies. Canal wall down mastoidectomy was performed in all patients. The differential staining properties--positive staining in the cholesteatoma and negative staining in the skin tissue (C+S-), negative staining in the cholesteatoma and positive staining in the skin tissue(C-S+)--were compared for bone erosion scores (BES), stage, and recurrence rates.
Isolated findings in the cholesteatoma tissues, without matching with the skin tissues, demonstrated that stage and recurrence rates were not related to findings in the cholesteatoma tissues (P > .05). However, C+S- for Ki-67 and C-S+ for p27 are risk factors for worse prognosis including advanced stage (P < .001 for Ki-67 and P = .008 for p27), BES values (P < .001 for Ki-67 and P = .001 for p27), and recurrence rates (P < .001 for Ki-67 and P = .037 for p27).
This is the first paper assessing the cholesteatoma prognosis according to the differential Ki-67 and p27 staining properties of cholesteatoma and healthy skin tissues. Cellular proliferation rate in the cholesteatoma is important but insufficient by itself for predicting the prognosis of cholesteatoma patients. Patients having lower basal levels of cellular proliferation rate and higher cellular activity in the cholesteatoma tissue are prone to worse prognosis with increased stage, recurrence rates, and degree of bone erosion.</description><subject>Adult</subject><subject>Adults</subject><subject>Antibodies</subject><subject>Cell cycle</subject><subject>Cholesteatoma</subject><subject>Cholesteatoma, Middle Ear - surgery</subject><subject>Comparative analysis</subject><subject>Cyclin-Dependent Kinase Inhibitor p27</subject><subject>Cyclin-dependent kinases</subject><subject>Humans</subject><subject>Ki-67 Antigen</subject><subject>Labeling</subject><subject>Mastoidectomy</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Original</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Skin</subject><subject>Statistical analysis</subject><subject>Surgery</subject><issn>2148-3817</issn><issn>1308-7649</issn><issn>2148-3817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>KPI</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk81v0zAUwCMEYtPYkSuy4DIOKf7MxwWpKgOqTVBpvVuO89x6JHFrJ2j8B_zZOHSMBu2AfEj8_Hs_Oy9-SfKS4Jkggr6zys0opmRWcsGeJKeU8CJlBcmfHr2fJOch2ArzLONYFPR5csI4w6UQ-DT5-cEaAx663qoGXd7tPETYdcgZdGXTLEeqq9GK5sh2aLF1DYQeVO9ahRau3SkPNeoduvkWl9c2hAHQKsas7gPqt-PEbToXbBiF83poejTX-8GOeRPdi-SZUU2A8_vnWbL-eLlefE6vv35aLubXqc4469OK1UUpaqCCa8KVMQSLknMDFHilAEqcEwZCFVwowanGGWQqx4ZTEJDn7CxZHrS1U7dy522r_A_plJW_A85vpPK91Q1IYaghpCoyrsu4mVBlkYMijFeEqhpIdL0_uHZD1UKtYxG9aibS6Upnt3LjvsuizAXHZRRc3Au82w-xFLK1QUPTqA7cECQVQjCeFWI895t_0Fs3-C5WaqSKeBkoZ3-pjYofYDvj4r56lMp5luMiDoEj9foRSu_sXh5Ds0egOGporXYdGBvjE-vbSUJkerjrN2oIQV6tlv_NLm--TNn0wGrvQvBgHgpMsBy7QMYukGMXyLELIv_q-K880H_uPPsFUtn-lA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Turkili, Serkan</creator><creator>Gorur, Kemal</creator><creator>Ismi, Onur</creator><creator>Serinsoz Linke, Ebru</creator><creator>Vaysioglu, Yusuf</creator><creator>Ozcan, Cengiz</creator><general>AVES</general><general>Mediterranean Society for Otology and Audiology</general><general>European Academy of Otology and Neurotology and the Politzer Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>KPI</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210701</creationdate><title>Differential Expression of Ki-67 and P27 in Cholesteatoma Compared to Skin Tissue Predicts the Prognosis of Adult Acquired Cholesteatoma</title><author>Turkili, Serkan ; Gorur, Kemal ; Ismi, Onur ; Serinsoz Linke, Ebru ; Vaysioglu, Yusuf ; Ozcan, Cengiz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c643t-b3d895de254c14aff105944fe2e4baee90713e5a845a542c06e6a70f42e5e773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Antibodies</topic><topic>Cell cycle</topic><topic>Cholesteatoma</topic><topic>Cholesteatoma, Middle Ear - surgery</topic><topic>Comparative analysis</topic><topic>Cyclin-Dependent Kinase Inhibitor p27</topic><topic>Cyclin-dependent kinases</topic><topic>Humans</topic><topic>Ki-67 Antigen</topic><topic>Labeling</topic><topic>Mastoidectomy</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Original</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Skin</topic><topic>Statistical analysis</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turkili, Serkan</creatorcontrib><creatorcontrib>Gorur, Kemal</creatorcontrib><creatorcontrib>Ismi, Onur</creatorcontrib><creatorcontrib>Serinsoz Linke, Ebru</creatorcontrib><creatorcontrib>Vaysioglu, Yusuf</creatorcontrib><creatorcontrib>Ozcan, Cengiz</creatorcontrib><creatorcontrib>Deparment of Medical Pathology, Pathology and Molecular Diagnostic Institution, Augsburg, Germany</creatorcontrib><creatorcontrib>Clinic of Otorhinolaryngology, Mersin State Hospital, Mersin, Turkey</creatorcontrib><creatorcontrib>Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Global Issues</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of International Advanced Otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turkili, Serkan</au><au>Gorur, Kemal</au><au>Ismi, Onur</au><au>Serinsoz Linke, Ebru</au><au>Vaysioglu, Yusuf</au><au>Ozcan, Cengiz</au><aucorp>Deparment of Medical Pathology, Pathology and Molecular Diagnostic Institution, Augsburg, Germany</aucorp><aucorp>Clinic of Otorhinolaryngology, Mersin State Hospital, Mersin, Turkey</aucorp><aucorp>Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Expression of Ki-67 and P27 in Cholesteatoma Compared to Skin Tissue Predicts the Prognosis of Adult Acquired Cholesteatoma</atitle><jtitle>Journal of International Advanced Otology</jtitle><addtitle>J Int Adv Otol</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>17</volume><issue>4</issue><spage>306</spage><epage>312</epage><pages>306-312</pages><issn>2148-3817</issn><issn>1308-7649</issn><eissn>2148-3817</eissn><abstract>The aim of this study was to compare the differential Ki-67 and p27 staining properties of acquired cholesteatoma in adult patients for prognostic analysis.
Forty-two adult patients with acquired cholesteatoma were enrolled. The cholesteatoma and matched meatal skin tissues of the patients were immunostained with Ki-67 and p27 antibodies. Canal wall down mastoidectomy was performed in all patients. The differential staining properties--positive staining in the cholesteatoma and negative staining in the skin tissue (C+S-), negative staining in the cholesteatoma and positive staining in the skin tissue(C-S+)--were compared for bone erosion scores (BES), stage, and recurrence rates.
Isolated findings in the cholesteatoma tissues, without matching with the skin tissues, demonstrated that stage and recurrence rates were not related to findings in the cholesteatoma tissues (P > .05). However, C+S- for Ki-67 and C-S+ for p27 are risk factors for worse prognosis including advanced stage (P < .001 for Ki-67 and P = .008 for p27), BES values (P < .001 for Ki-67 and P = .001 for p27), and recurrence rates (P < .001 for Ki-67 and P = .037 for p27).
This is the first paper assessing the cholesteatoma prognosis according to the differential Ki-67 and p27 staining properties of cholesteatoma and healthy skin tissues. Cellular proliferation rate in the cholesteatoma is important but insufficient by itself for predicting the prognosis of cholesteatoma patients. Patients having lower basal levels of cellular proliferation rate and higher cellular activity in the cholesteatoma tissue are prone to worse prognosis with increased stage, recurrence rates, and degree of bone erosion.</abstract><cop>Turkey</cop><pub>AVES</pub><pmid>34309550</pmid><doi>10.5152/iao.2021.9453</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2148-3817 |
| ispartof | Journal of International Advanced Otology, 2021-07, Vol.17 (4), p.306-312 |
| issn | 2148-3817 1308-7649 2148-3817 |
| language | eng |
| recordid | cdi_gale_infotraccpiq_670808050 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Adults Antibodies Cell cycle Cholesteatoma Cholesteatoma, Middle Ear - surgery Comparative analysis Cyclin-Dependent Kinase Inhibitor p27 Cyclin-dependent kinases Humans Ki-67 Antigen Labeling Mastoidectomy Medical research Medicine, Experimental Original Pathogenesis Patients Prognosis Recurrence Skin Statistical analysis Surgery |
| title | Differential Expression of Ki-67 and P27 in Cholesteatoma Compared to Skin Tissue Predicts the Prognosis of Adult Acquired Cholesteatoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T14%3A41%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20Expression%20of%20Ki-67%20and%20P27%20in%20Cholesteatoma%20Compared%20to%20Skin%20Tissue%20Predicts%20the%20Prognosis%20of%20Adult%20Acquired%20Cholesteatoma&rft.jtitle=Journal%20of%20International%20Advanced%20Otology&rft.au=Turkili,%20Serkan&rft.aucorp=Deparment%20of%20Medical%20Pathology,%20Pathology%20and%20Molecular%20Diagnostic%20Institution,%20Augsburg,%20Germany&rft.date=2021-07-01&rft.volume=17&rft.issue=4&rft.spage=306&rft.epage=312&rft.pages=306-312&rft.issn=2148-3817&rft.eissn=2148-3817&rft_id=info:doi/10.5152/iao.2021.9453&rft_dat=%3Cgale_doaj_%3EA670808050%3C/gale_doaj_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2558152243&rft_id=info:pmid/34309550&rft_galeid=A670808050&rft_doaj_id=oai_doaj_org_article_5f2f11b864c94c15a987ea134b12ade1&rfr_iscdi=true |