Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients
Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients Tonny Jensen , MD 1 , Quan Truong 1 , Merete Frandsen 1 , Bo Dinesen , MD 1 and Steen Stender , MD 2 1 Steno Diabetes Center, Gentofte, Denmark 2 Department of Clinical Chemistry...
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| Veröffentlicht in: | Diabetes care 2002-11, Vol.25 (11), p.1914-1918 |
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| creator | JENSEN, Tonny QUAN TRUONG FRANDSEN, Merete DINESEN, Bo STENDER, Steen |
| description | Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients
Tonny Jensen , MD 1 ,
Quan Truong 1 ,
Merete Frandsen 1 ,
Bo Dinesen , MD 1 and
Steen Stender , MD 2
1 Steno Diabetes Center, Gentofte, Denmark
2 Department of Clinical Chemistry, KAS Gentofte, Hellerup, Denmark
Abstract
OBJECTIVE —To compare direct-measured HDL cholesterol with HDL cholesterol measured by a precipitation method.
RESEARCH DESIGN AND METHODS —We compared a homogeneous assay for direct HDL cholesterol analysis with the phosphotungstic acid magnesium chloride precipitation
method in 55 type 1 diabetic patients, 70 type 2 diabetic patients, and 82 nondiabetic normal control subjects with plasma
triglyceride levels 1.063; these apo B-containing
lipoproteins are suggested to be coprecipitated with the phosphotungstic acid method. We also measured LDL cholesterol directly
by a LDL cholesterol plus method and found no significant differences between this method and LDL cholesterol calculated from
Friedewald’s formula.
CONCLUSIONS —Direct homogeneous assay for HDL cholesterol determination in diabetic patients seems not to exhibit a negative bias, in
contrast to the precipitation method, when compared with the ultracentrifugation method. In addition, the direct assay saves
time and is not influenced by type of diabetes or degree of metabolic control.
apo, apolipoprotein
Footnotes
Address correspondence and reprint requests to Tonny Jensen, MD, Clinic of Endocrinology, Hvidovre Hospital, 30 Kettegaard
Alle, DK-2650 Hvidovre, Denmark. E-mail: tonny.jensen.tj{at}hh.hosp.dk .
Received for publication 13 February 2001 and accepted in revised form 2 August 2002.
A table elsewhere in this issue shows conventional |
| doi_str_mv | 10.2337/diacare.25.11.1914 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pasca</sourceid><recordid>TN_cdi_gale_infotracacademiconefile_A94142210</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A94142210</galeid><sourcerecordid>A94142210</sourcerecordid><originalsourceid>FETCH-LOGICAL-c484t-41ed0f141de8802d6e604ded42e8d756a0d5781ae566063d3a4cea6b1ca9b9fa3</originalsourceid><addsrcrecordid>eNptkcGO0zAQhi0EYkvhBTggX9gLm2I7tpscqy7QlYrYA4hjNLUnjVESF9sV6tvjbiPtpfJhZM83_4znJ-Q9ZwtRlsvP1oGBgAuhFpwveM3lCzLjdakKpWT1kswYl3Wh6lrckDcx_mGMSVlVr8kNF5LxZSlm5LT2wwGCi36kvqVAN37wexzRHyNdxQgn-tulLiceAxp3cAmSy-x3TJ23tPWBpg7zFeIx4IBjOsts7rd03fkeY8Lge-pGeu9gh8kZ-pgFMhbfklct9BHfTXFOfn398nO9KbY_vj2sV9vCyEqmQnK0rOWSW6wqJqxGzaRFKwVWdqk0MKuWFQdUWjNd2hKkQdA7bqDe1S2Uc3J70T0E__eYJ2oGFw32PTx9slkKLbTO25iTuwu4hx4bN7Y-BTDnXQTo_Yity8-rWnIpBGcZL67g-VgcnLnGiwtvgo8xYNscghsgnBrOmrOfzeRnI1TDeXP2Mxd9mIY_7ga0zyWTgRn4OAEQDfRtgNG4-MzJUnOtVeY-XbjO7bt_LnexT4ZgvNb2Pwlgubs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72626617</pqid></control><display><type>article</type><title>Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>JENSEN, Tonny ; QUAN TRUONG ; FRANDSEN, Merete ; DINESEN, Bo ; STENDER, Steen</creator><creatorcontrib>JENSEN, Tonny ; QUAN TRUONG ; FRANDSEN, Merete ; DINESEN, Bo ; STENDER, Steen</creatorcontrib><description>Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients
Tonny Jensen , MD 1 ,
Quan Truong 1 ,
Merete Frandsen 1 ,
Bo Dinesen , MD 1 and
Steen Stender , MD 2
1 Steno Diabetes Center, Gentofte, Denmark
2 Department of Clinical Chemistry, KAS Gentofte, Hellerup, Denmark
Abstract
OBJECTIVE —To compare direct-measured HDL cholesterol with HDL cholesterol measured by a precipitation method.
RESEARCH DESIGN AND METHODS —We compared a homogeneous assay for direct HDL cholesterol analysis with the phosphotungstic acid magnesium chloride precipitation
method in 55 type 1 diabetic patients, 70 type 2 diabetic patients, and 82 nondiabetic normal control subjects with plasma
triglyceride levels <4.6 mmol/l. The cholesterol content of HDL determined by the direct assay was overall 0.1 mmol/l higher
in all three groups than HDL cholesterol measured after precipitation, but the two methods were closely correlated ( r 2 = 0.98, P < 0.001).
RESULTS —HbA 1c , blood glucose, serum albumin, serum bilirubin, or triglyceride did not influence the differences of the two HDL cholesterol
measurements. Because we have previously shown HDL cholesterol isolated by phosphotungstic acid precipitation to be lower
than that by ultracentrifugation, the positive bias found in this study was expected. It seems that the direct HDL cholesterol
assay reacts with apolipoprotein (apo) B-containing lipoproteins in the fraction with a density of >1.063; these apo B-containing
lipoproteins are suggested to be coprecipitated with the phosphotungstic acid method. We also measured LDL cholesterol directly
by a LDL cholesterol plus method and found no significant differences between this method and LDL cholesterol calculated from
Friedewald’s formula.
CONCLUSIONS —Direct homogeneous assay for HDL cholesterol determination in diabetic patients seems not to exhibit a negative bias, in
contrast to the precipitation method, when compared with the ultracentrifugation method. In addition, the direct assay saves
time and is not influenced by type of diabetes or degree of metabolic control.
apo, apolipoprotein
Footnotes
Address correspondence and reprint requests to Tonny Jensen, MD, Clinic of Endocrinology, Hvidovre Hospital, 30 Kettegaard
Alle, DK-2650 Hvidovre, Denmark. E-mail: tonny.jensen.tj{at}hh.hosp.dk .
Received for publication 13 February 2001 and accepted in revised form 2 August 2002.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
DIABETES CARE</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/diacare.25.11.1914</identifier><identifier>PMID: 12401732</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Chemical Precipitation ; Cholesterol - blood ; Cholesterol, HDL ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Glycated Hemoglobin A - analysis ; Humans ; Measurement ; Medical sciences ; Middle Aged ; Patient Selection ; Physiological aspects ; Reference Values ; Regression Analysis ; Reproducibility of Results ; Serum Albumin - analysis ; Triglycerides - blood</subject><ispartof>Diabetes care, 2002-11, Vol.25 (11), p.1914-1918</ispartof><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2002 American Diabetes Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-41ed0f141de8802d6e604ded42e8d756a0d5781ae566063d3a4cea6b1ca9b9fa3</citedby><cites>FETCH-LOGICAL-c484t-41ed0f141de8802d6e604ded42e8d756a0d5781ae566063d3a4cea6b1ca9b9fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14361665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12401732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JENSEN, Tonny</creatorcontrib><creatorcontrib>QUAN TRUONG</creatorcontrib><creatorcontrib>FRANDSEN, Merete</creatorcontrib><creatorcontrib>DINESEN, Bo</creatorcontrib><creatorcontrib>STENDER, Steen</creatorcontrib><title>Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients
Tonny Jensen , MD 1 ,
Quan Truong 1 ,
Merete Frandsen 1 ,
Bo Dinesen , MD 1 and
Steen Stender , MD 2
1 Steno Diabetes Center, Gentofte, Denmark
2 Department of Clinical Chemistry, KAS Gentofte, Hellerup, Denmark
Abstract
OBJECTIVE —To compare direct-measured HDL cholesterol with HDL cholesterol measured by a precipitation method.
RESEARCH DESIGN AND METHODS —We compared a homogeneous assay for direct HDL cholesterol analysis with the phosphotungstic acid magnesium chloride precipitation
method in 55 type 1 diabetic patients, 70 type 2 diabetic patients, and 82 nondiabetic normal control subjects with plasma
triglyceride levels <4.6 mmol/l. The cholesterol content of HDL determined by the direct assay was overall 0.1 mmol/l higher
in all three groups than HDL cholesterol measured after precipitation, but the two methods were closely correlated ( r 2 = 0.98, P < 0.001).
RESULTS —HbA 1c , blood glucose, serum albumin, serum bilirubin, or triglyceride did not influence the differences of the two HDL cholesterol
measurements. Because we have previously shown HDL cholesterol isolated by phosphotungstic acid precipitation to be lower
than that by ultracentrifugation, the positive bias found in this study was expected. It seems that the direct HDL cholesterol
assay reacts with apolipoprotein (apo) B-containing lipoproteins in the fraction with a density of >1.063; these apo B-containing
lipoproteins are suggested to be coprecipitated with the phosphotungstic acid method. We also measured LDL cholesterol directly
by a LDL cholesterol plus method and found no significant differences between this method and LDL cholesterol calculated from
Friedewald’s formula.
CONCLUSIONS —Direct homogeneous assay for HDL cholesterol determination in diabetic patients seems not to exhibit a negative bias, in
contrast to the precipitation method, when compared with the ultracentrifugation method. In addition, the direct assay saves
time and is not influenced by type of diabetes or degree of metabolic control.
apo, apolipoprotein
Footnotes
Address correspondence and reprint requests to Tonny Jensen, MD, Clinic of Endocrinology, Hvidovre Hospital, 30 Kettegaard
Alle, DK-2650 Hvidovre, Denmark. E-mail: tonny.jensen.tj{at}hh.hosp.dk .
Received for publication 13 February 2001 and accepted in revised form 2 August 2002.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
DIABETES CARE</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Chemical Precipitation</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Measurement</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patient Selection</subject><subject>Physiological aspects</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Serum Albumin - analysis</subject><subject>Triglycerides - blood</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcGO0zAQhi0EYkvhBTggX9gLm2I7tpscqy7QlYrYA4hjNLUnjVESF9sV6tvjbiPtpfJhZM83_4znJ-Q9ZwtRlsvP1oGBgAuhFpwveM3lCzLjdakKpWT1kswYl3Wh6lrckDcx_mGMSVlVr8kNF5LxZSlm5LT2wwGCi36kvqVAN37wexzRHyNdxQgn-tulLiceAxp3cAmSy-x3TJ23tPWBpg7zFeIx4IBjOsts7rd03fkeY8Lge-pGeu9gh8kZ-pgFMhbfklct9BHfTXFOfn398nO9KbY_vj2sV9vCyEqmQnK0rOWSW6wqJqxGzaRFKwVWdqk0MKuWFQdUWjNd2hKkQdA7bqDe1S2Uc3J70T0E__eYJ2oGFw32PTx9slkKLbTO25iTuwu4hx4bN7Y-BTDnXQTo_Yity8-rWnIpBGcZL67g-VgcnLnGiwtvgo8xYNscghsgnBrOmrOfzeRnI1TDeXP2Mxd9mIY_7ga0zyWTgRn4OAEQDfRtgNG4-MzJUnOtVeY-XbjO7bt_LnexT4ZgvNb2Pwlgubs</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>JENSEN, Tonny</creator><creator>QUAN TRUONG</creator><creator>FRANDSEN, Merete</creator><creator>DINESEN, Bo</creator><creator>STENDER, Steen</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients</title><author>JENSEN, Tonny ; QUAN TRUONG ; FRANDSEN, Merete ; DINESEN, Bo ; STENDER, Steen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-41ed0f141de8802d6e604ded42e8d756a0d5781ae566063d3a4cea6b1ca9b9fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Chemical Precipitation</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Measurement</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patient Selection</topic><topic>Physiological aspects</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Serum Albumin - analysis</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JENSEN, Tonny</creatorcontrib><creatorcontrib>QUAN TRUONG</creatorcontrib><creatorcontrib>FRANDSEN, Merete</creatorcontrib><creatorcontrib>DINESEN, Bo</creatorcontrib><creatorcontrib>STENDER, Steen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JENSEN, Tonny</au><au>QUAN TRUONG</au><au>FRANDSEN, Merete</au><au>DINESEN, Bo</au><au>STENDER, Steen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>25</volume><issue>11</issue><spage>1914</spage><epage>1918</epage><pages>1914-1918</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients
Tonny Jensen , MD 1 ,
Quan Truong 1 ,
Merete Frandsen 1 ,
Bo Dinesen , MD 1 and
Steen Stender , MD 2
1 Steno Diabetes Center, Gentofte, Denmark
2 Department of Clinical Chemistry, KAS Gentofte, Hellerup, Denmark
Abstract
OBJECTIVE —To compare direct-measured HDL cholesterol with HDL cholesterol measured by a precipitation method.
RESEARCH DESIGN AND METHODS —We compared a homogeneous assay for direct HDL cholesterol analysis with the phosphotungstic acid magnesium chloride precipitation
method in 55 type 1 diabetic patients, 70 type 2 diabetic patients, and 82 nondiabetic normal control subjects with plasma
triglyceride levels <4.6 mmol/l. The cholesterol content of HDL determined by the direct assay was overall 0.1 mmol/l higher
in all three groups than HDL cholesterol measured after precipitation, but the two methods were closely correlated ( r 2 = 0.98, P < 0.001).
RESULTS —HbA 1c , blood glucose, serum albumin, serum bilirubin, or triglyceride did not influence the differences of the two HDL cholesterol
measurements. Because we have previously shown HDL cholesterol isolated by phosphotungstic acid precipitation to be lower
than that by ultracentrifugation, the positive bias found in this study was expected. It seems that the direct HDL cholesterol
assay reacts with apolipoprotein (apo) B-containing lipoproteins in the fraction with a density of >1.063; these apo B-containing
lipoproteins are suggested to be coprecipitated with the phosphotungstic acid method. We also measured LDL cholesterol directly
by a LDL cholesterol plus method and found no significant differences between this method and LDL cholesterol calculated from
Friedewald’s formula.
CONCLUSIONS —Direct homogeneous assay for HDL cholesterol determination in diabetic patients seems not to exhibit a negative bias, in
contrast to the precipitation method, when compared with the ultracentrifugation method. In addition, the direct assay saves
time and is not influenced by type of diabetes or degree of metabolic control.
apo, apolipoprotein
Footnotes
Address correspondence and reprint requests to Tonny Jensen, MD, Clinic of Endocrinology, Hvidovre Hospital, 30 Kettegaard
Alle, DK-2650 Hvidovre, Denmark. E-mail: tonny.jensen.tj{at}hh.hosp.dk .
Received for publication 13 February 2001 and accepted in revised form 2 August 2002.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
DIABETES CARE</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>12401732</pmid><doi>10.2337/diacare.25.11.1914</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2002-11, Vol.25 (11), p.1914-1918 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_gale_infotracacademiconefile_A94142210 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Chemical Precipitation Cholesterol - blood Cholesterol, HDL Cholesterol, HDL - blood Cholesterol, LDL - blood Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glycated Hemoglobin A - analysis Humans Measurement Medical sciences Middle Aged Patient Selection Physiological aspects Reference Values Regression Analysis Reproducibility of Results Serum Albumin - analysis Triglycerides - blood |
| title | Comparison of a Homogeneous Assay With a Precipitation Method for the Measurement of HDL Cholesterol in Diabetic Patients |
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