Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam
Rotavirus (RV), norovirus (NoV), sapovirus (SaV), and human astrovirus (HAstV) are the most common viral causes of gastroenteritis in children worldwide. From 2016 to 2021, we conducted a cross-sectional descriptive study to determine the prevalence of these viruses in hospitalized children under fi...
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| Veröffentlicht in: | Viruses 2023, Vol.15 (11) |
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| creator | Mai, Chu Thi Ngoc Ly, Le Thi Khanh Doan, Yen Hai Oka, Tomoichiro Mai, Le Thi Phuong Quyet, Nguyen Tu Mai, Tran Ngoc Phuong Thiem, Vu Dinh Anh, Lai Tuan Van Sanh, Le Hien, Nguyen Dang Anh, Dang Duc Parashar, Umesh D Tate, Jacqueline E Van Trang, Nguyen |
| description | Rotavirus (RV), norovirus (NoV), sapovirus (SaV), and human astrovirus (HAstV) are the most common viral causes of gastroenteritis in children worldwide. From 2016 to 2021, we conducted a cross-sectional descriptive study to determine the prevalence of these viruses in hospitalized children under five years old in Nam Dinh and Thua Thien Hue provinces in Vietnam during the pilot introduction of the RV vaccine, Rotavin-M1 (POLYVAC, Hanoi, Vietnam). We randomly selected 2317/6718 (34%) acute diarrheal samples from children |
| doi_str_mv | 10.3390/v15112164 |
| format | Report |
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From 2016 to 2021, we conducted a cross-sectional descriptive study to determine the prevalence of these viruses in hospitalized children under five years old in Nam Dinh and Thua Thien Hue provinces in Vietnam during the pilot introduction of the RV vaccine, Rotavin-M1 (POLYVAC, Hanoi, Vietnam). We randomly selected 2317/6718 (34%) acute diarrheal samples from children <5 years of age enrolled at seven sentinel hospitals from December 2016 to May 2021; this period included one year surveillance pre-vaccination from December 2016 to November 2017. An ELISA kit (Premier Rotaclone[sup.®] , Meridian Bioscience, Inc., Cincinnati, OH, USA) was used to detect RV, and two multiplex real-time RT-PCR assays were used for the detection of NoV, SaV and HAstV. The prevalence of RV (single infection) was reduced from 41.6% to 22.7% (p < 0.0001) between pre- and post-vaccination periods, while the single NoV infection prevalence more than doubled from 8.8% to 21.8% (p < 0.0001). The SaV and HAstV prevalences slightly increased from 1.9% to 3.4% (p = 0.03) and 2.1% to 3.3% (p = 0.09), respectively, during the same period. Viral co-infections decreased from 7.2% to 6.0% (p = 0.24), mainly due to a reduction in RV infection. Among the genotypeable samples, NoV GII.4, SaV GI.1, and HAstV-1 were the dominant types, representing 57.3%, 32.1%, and 55.0% among the individual viral groups, respectively. As the prevalence of RV decreases following the national RV vaccine introduction in Vietnam, other viral pathogens account for a larger proportion of the remaining diarrhea burden and require continuing close monitoring.</description><identifier>ISSN: 1999-4915</identifier><identifier>EISSN: 1999-4915</identifier><identifier>DOI: 10.3390/v15112164</identifier><language>eng</language><publisher>MDPI AG</publisher><subject>Causes of ; Demographic aspects ; Diarrhea in children ; Diseases ; Dosage and administration ; Drug therapy ; Gastroenteritis ; Genetic aspects ; Hospital patients ; Identification and classification ; Pediatric research ; RNA viruses ; Viral vaccines</subject><ispartof>Viruses, 2023, Vol.15 (11)</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,780,860,4476,27902</link.rule.ids></links><search><creatorcontrib>Mai, Chu Thi Ngoc</creatorcontrib><creatorcontrib>Ly, Le Thi Khanh</creatorcontrib><creatorcontrib>Doan, Yen Hai</creatorcontrib><creatorcontrib>Oka, Tomoichiro</creatorcontrib><creatorcontrib>Mai, Le Thi Phuong</creatorcontrib><creatorcontrib>Quyet, Nguyen Tu</creatorcontrib><creatorcontrib>Mai, Tran Ngoc Phuong</creatorcontrib><creatorcontrib>Thiem, Vu Dinh</creatorcontrib><creatorcontrib>Anh, Lai Tuan</creatorcontrib><creatorcontrib>Van Sanh, Le</creatorcontrib><creatorcontrib>Hien, Nguyen Dang</creatorcontrib><creatorcontrib>Anh, Dang Duc</creatorcontrib><creatorcontrib>Parashar, Umesh D</creatorcontrib><creatorcontrib>Tate, Jacqueline E</creatorcontrib><creatorcontrib>Van Trang, Nguyen</creatorcontrib><title>Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam</title><title>Viruses</title><description>Rotavirus (RV), norovirus (NoV), sapovirus (SaV), and human astrovirus (HAstV) are the most common viral causes of gastroenteritis in children worldwide. From 2016 to 2021, we conducted a cross-sectional descriptive study to determine the prevalence of these viruses in hospitalized children under five years old in Nam Dinh and Thua Thien Hue provinces in Vietnam during the pilot introduction of the RV vaccine, Rotavin-M1 (POLYVAC, Hanoi, Vietnam). We randomly selected 2317/6718 (34%) acute diarrheal samples from children <5 years of age enrolled at seven sentinel hospitals from December 2016 to May 2021; this period included one year surveillance pre-vaccination from December 2016 to November 2017. An ELISA kit (Premier Rotaclone[sup.®] , Meridian Bioscience, Inc., Cincinnati, OH, USA) was used to detect RV, and two multiplex real-time RT-PCR assays were used for the detection of NoV, SaV and HAstV. The prevalence of RV (single infection) was reduced from 41.6% to 22.7% (p < 0.0001) between pre- and post-vaccination periods, while the single NoV infection prevalence more than doubled from 8.8% to 21.8% (p < 0.0001). The SaV and HAstV prevalences slightly increased from 1.9% to 3.4% (p = 0.03) and 2.1% to 3.3% (p = 0.09), respectively, during the same period. Viral co-infections decreased from 7.2% to 6.0% (p = 0.24), mainly due to a reduction in RV infection. Among the genotypeable samples, NoV GII.4, SaV GI.1, and HAstV-1 were the dominant types, representing 57.3%, 32.1%, and 55.0% among the individual viral groups, respectively. As the prevalence of RV decreases following the national RV vaccine introduction in Vietnam, other viral pathogens account for a larger proportion of the remaining diarrhea burden and require continuing close monitoring.</description><subject>Causes of</subject><subject>Demographic aspects</subject><subject>Diarrhea in children</subject><subject>Diseases</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Gastroenteritis</subject><subject>Genetic aspects</subject><subject>Hospital patients</subject><subject>Identification and classification</subject><subject>Pediatric research</subject><subject>RNA viruses</subject><subject>Viral vaccines</subject><issn>1999-4915</issn><issn>1999-4915</issn><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2023</creationdate><recordtype>report</recordtype><sourceid/><recordid>eNqVjk1OwzAQhS0EEuVnwQ3mAi12kyZ4iSqg7CqEuq1GzqQMSsbIdrLoJbgyDmLBtprFjN7oe-8pdWf0oiisvh_NypilqcozNTPW2nlpzer8332prmL81LqqrK5n6nsbaMSOxBGgNLD-wIAuUeAjJvYCvoUXjCl4kklNHGHHYYgUAXsvB9j4-MUJOz7ShHPXBBJohsD5ibDlzid48wnHCYMdOsdC8CrZsxncbwhLNqUk2N-oixa7SLd_-1otnp_e15v5IZfcs7Q-5X55GurZeaGWs_5Y12VRP2hTFScDP2d1ZOU</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Mai, Chu Thi Ngoc</creator><creator>Ly, Le Thi Khanh</creator><creator>Doan, Yen Hai</creator><creator>Oka, Tomoichiro</creator><creator>Mai, Le Thi Phuong</creator><creator>Quyet, Nguyen Tu</creator><creator>Mai, Tran Ngoc Phuong</creator><creator>Thiem, Vu Dinh</creator><creator>Anh, Lai Tuan</creator><creator>Van Sanh, Le</creator><creator>Hien, Nguyen Dang</creator><creator>Anh, Dang Duc</creator><creator>Parashar, Umesh D</creator><creator>Tate, Jacqueline E</creator><creator>Van Trang, Nguyen</creator><general>MDPI AG</general><scope/></search><sort><creationdate>20231001</creationdate><title>Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam</title><author>Mai, Chu Thi Ngoc ; Ly, Le Thi Khanh ; Doan, Yen Hai ; Oka, Tomoichiro ; Mai, Le Thi Phuong ; Quyet, Nguyen Tu ; Mai, Tran Ngoc Phuong ; Thiem, Vu Dinh ; Anh, Lai Tuan ; Van Sanh, Le ; Hien, Nguyen Dang ; Anh, Dang Duc ; Parashar, Umesh D ; Tate, Jacqueline E ; Van Trang, Nguyen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_infotracacademiconefile_A7743780163</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Causes of</topic><topic>Demographic aspects</topic><topic>Diarrhea in children</topic><topic>Diseases</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Gastroenteritis</topic><topic>Genetic aspects</topic><topic>Hospital patients</topic><topic>Identification and classification</topic><topic>Pediatric research</topic><topic>RNA viruses</topic><topic>Viral vaccines</topic><toplevel>online_resources</toplevel><creatorcontrib>Mai, Chu Thi Ngoc</creatorcontrib><creatorcontrib>Ly, Le Thi Khanh</creatorcontrib><creatorcontrib>Doan, Yen Hai</creatorcontrib><creatorcontrib>Oka, Tomoichiro</creatorcontrib><creatorcontrib>Mai, Le Thi Phuong</creatorcontrib><creatorcontrib>Quyet, Nguyen Tu</creatorcontrib><creatorcontrib>Mai, Tran Ngoc Phuong</creatorcontrib><creatorcontrib>Thiem, Vu Dinh</creatorcontrib><creatorcontrib>Anh, Lai Tuan</creatorcontrib><creatorcontrib>Van Sanh, Le</creatorcontrib><creatorcontrib>Hien, Nguyen Dang</creatorcontrib><creatorcontrib>Anh, Dang Duc</creatorcontrib><creatorcontrib>Parashar, Umesh D</creatorcontrib><creatorcontrib>Tate, Jacqueline E</creatorcontrib><creatorcontrib>Van Trang, Nguyen</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mai, Chu Thi Ngoc</au><au>Ly, Le Thi Khanh</au><au>Doan, Yen Hai</au><au>Oka, Tomoichiro</au><au>Mai, Le Thi Phuong</au><au>Quyet, Nguyen Tu</au><au>Mai, Tran Ngoc Phuong</au><au>Thiem, Vu Dinh</au><au>Anh, Lai Tuan</au><au>Van Sanh, Le</au><au>Hien, Nguyen Dang</au><au>Anh, Dang Duc</au><au>Parashar, Umesh D</au><au>Tate, Jacqueline E</au><au>Van Trang, Nguyen</au><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><atitle>Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam</atitle><jtitle>Viruses</jtitle><date>2023-10-01</date><risdate>2023</risdate><volume>15</volume><issue>11</issue><issn>1999-4915</issn><eissn>1999-4915</eissn><abstract>Rotavirus (RV), norovirus (NoV), sapovirus (SaV), and human astrovirus (HAstV) are the most common viral causes of gastroenteritis in children worldwide. From 2016 to 2021, we conducted a cross-sectional descriptive study to determine the prevalence of these viruses in hospitalized children under five years old in Nam Dinh and Thua Thien Hue provinces in Vietnam during the pilot introduction of the RV vaccine, Rotavin-M1 (POLYVAC, Hanoi, Vietnam). We randomly selected 2317/6718 (34%) acute diarrheal samples from children <5 years of age enrolled at seven sentinel hospitals from December 2016 to May 2021; this period included one year surveillance pre-vaccination from December 2016 to November 2017. An ELISA kit (Premier Rotaclone[sup.®] , Meridian Bioscience, Inc., Cincinnati, OH, USA) was used to detect RV, and two multiplex real-time RT-PCR assays were used for the detection of NoV, SaV and HAstV. The prevalence of RV (single infection) was reduced from 41.6% to 22.7% (p < 0.0001) between pre- and post-vaccination periods, while the single NoV infection prevalence more than doubled from 8.8% to 21.8% (p < 0.0001). The SaV and HAstV prevalences slightly increased from 1.9% to 3.4% (p = 0.03) and 2.1% to 3.3% (p = 0.09), respectively, during the same period. Viral co-infections decreased from 7.2% to 6.0% (p = 0.24), mainly due to a reduction in RV infection. Among the genotypeable samples, NoV GII.4, SaV GI.1, and HAstV-1 were the dominant types, representing 57.3%, 32.1%, and 55.0% among the individual viral groups, respectively. As the prevalence of RV decreases following the national RV vaccine introduction in Vietnam, other viral pathogens account for a larger proportion of the remaining diarrhea burden and require continuing close monitoring.</abstract><pub>MDPI AG</pub><doi>10.3390/v15112164</doi></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Causes of Demographic aspects Diarrhea in children Diseases Dosage and administration Drug therapy Gastroenteritis Genetic aspects Hospital patients Identification and classification Pediatric research RNA viruses Viral vaccines |
| title | Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam |
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