Development and Immunoprotection of Bacterium-like Particle Vaccine against Infectious Bronchitis in Chickens
Infectious bronchitis (IB) is a major threat to the global poultry industry. Despite the availability of commercial vaccines, the IB epidemic has not been effectively controlled. The exploration of novel IBV vaccines may provide a new way to prevent and control IB. In this study, BLP-S1, a bacterium...
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| Veröffentlicht in: | Vaccines 2023, Vol.11 (8) |
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| container_issue | 8 |
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| container_title | Vaccines |
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| creator | Zhang, Pengju Yang, Tiantian Sun, Yixue Qiao, Haiying Hu, Nianzhi Li, Xintao Wang, Weixia Zhang, Lichun Cong, Yanlong |
| description | Infectious bronchitis (IB) is a major threat to the global poultry industry. Despite the availability of commercial vaccines, the IB epidemic has not been effectively controlled. The exploration of novel IBV vaccines may provide a new way to prevent and control IB. In this study, BLP-S1, a bacterium-like particle displaying the S1 subunit of infectious bronchitis virus (IBV), was constructed using the GEM-PA surface display system. The immunoprotective efficacy results showed that BLP-S1 can effectively induce specific IgG and sIgA immune responses, providing a protection rate of 90% against IBV infection in 14-day-old commercial chickens. These results suggest that BLP-S1 has potential for the development of novel vaccines with good immunogenicity and immunoprotection. |
| doi_str_mv | 10.3390/vaccines11081292 |
| format | Report |
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Despite the availability of commercial vaccines, the IB epidemic has not been effectively controlled. The exploration of novel IBV vaccines may provide a new way to prevent and control IB. In this study, BLP-S1, a bacterium-like particle displaying the S1 subunit of infectious bronchitis virus (IBV), was constructed using the GEM-PA surface display system. The immunoprotective efficacy results showed that BLP-S1 can effectively induce specific IgG and sIgA immune responses, providing a protection rate of 90% against IBV infection in 14-day-old commercial chickens. These results suggest that BLP-S1 has potential for the development of novel vaccines with good immunogenicity and immunoprotection.</description><identifier>ISSN: 2076-393X</identifier><identifier>EISSN: 2076-393X</identifier><identifier>DOI: 10.3390/vaccines11081292</identifier><language>eng</language><publisher>MDPI AG</publisher><subject>Bacterial vaccines ; Bronchitis ; Chickens ; Design and construction ; Development and progression ; Evaluation ; Health aspects ; Prevention</subject><ispartof>Vaccines, 2023, Vol.11 (8)</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,780,860,4476,27902</link.rule.ids></links><search><creatorcontrib>Zhang, Pengju</creatorcontrib><creatorcontrib>Yang, Tiantian</creatorcontrib><creatorcontrib>Sun, Yixue</creatorcontrib><creatorcontrib>Qiao, Haiying</creatorcontrib><creatorcontrib>Hu, Nianzhi</creatorcontrib><creatorcontrib>Li, Xintao</creatorcontrib><creatorcontrib>Wang, Weixia</creatorcontrib><creatorcontrib>Zhang, Lichun</creatorcontrib><creatorcontrib>Cong, Yanlong</creatorcontrib><title>Development and Immunoprotection of Bacterium-like Particle Vaccine against Infectious Bronchitis in Chickens</title><title>Vaccines</title><description>Infectious bronchitis (IB) is a major threat to the global poultry industry. 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Despite the availability of commercial vaccines, the IB epidemic has not been effectively controlled. The exploration of novel IBV vaccines may provide a new way to prevent and control IB. In this study, BLP-S1, a bacterium-like particle displaying the S1 subunit of infectious bronchitis virus (IBV), was constructed using the GEM-PA surface display system. The immunoprotective efficacy results showed that BLP-S1 can effectively induce specific IgG and sIgA immune responses, providing a protection rate of 90% against IBV infection in 14-day-old commercial chickens. These results suggest that BLP-S1 has potential for the development of novel vaccines with good immunogenicity and immunoprotection.</abstract><pub>MDPI AG</pub><doi>10.3390/vaccines11081292</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2076-393X |
| ispartof | Vaccines, 2023, Vol.11 (8) |
| issn | 2076-393X 2076-393X |
| language | eng |
| recordid | cdi_gale_infotracacademiconefile_A762549352 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Bacterial vaccines Bronchitis Chickens Design and construction Development and progression Evaluation Health aspects Prevention |
| title | Development and Immunoprotection of Bacterium-like Particle Vaccine against Infectious Bronchitis in Chickens |
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