Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege

Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To address this knowledge gap, we used sensitive and quantitative PCR detection to show that people with MS were more likely...

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Veröffentlicht in:	Journal of Clinical Investigation 2023, Vol.133 (9)
Hauptverfasser:	Ma, Yinghua, Sannino, David, Linden, Jennifer R, Haigh, Sylvia, Zhao, Baohua, Grigg, John B, Zumbo, Paul, Dundar, Friederike, Butler, Daniel, Profaci, Caterina P, Telesford, Kiel, Winokur, Paige N, Rumah, Kareem R, Gauthier, Susan A, Fischetti, Vincent A, McClane, Bruce A, Uzal, Francisco A, Zexter, Lily, Mazzucco, Michael, Rudick, Richard, Danko, David, Balmuth, Evan, Nealon, Nancy, Perumal, Jai, Kaunzner, Ulrike, Brito, Ilana L, Chen, Zhengming, Xiang, Jenny Z, Betel, Doron, Daneman, Richard, Sonnenberg, Gregory F, Mason, Christopher E, Vartanian, Timothy
Format:	Report
Sprache:	eng
Schlagworte:	Bacterial toxins Care and treatment Central nervous system Clostridium Development and progression Genetic aspects Health aspects Multiple sclerosis
Online-Zugang:	Volltext
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