Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence

Background and aims Summarised in polygenic risk scores (PRS), the effect of common, low penetrant genetic variants associated with colorectal cancer (CRC), can be used for risk stratification. Methods To assess the combined impact of the PRS and other main factors on CRC risk, 163,516 individuals f...

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Veröffentlicht in:	BMC Medical Genomics 2023, Vol.16 (1)
Hauptverfasser:	Hassanin, Emadeldin, Spier, Isabel, Bobbili, Dheeraj R, Aldisi, Rana, Klinkhammer, Hannah, David, Friederike, Dueéas, Nuria, Hüneburg, Robert, Perne, Claudia, Brunet, Joan, Capella, Gabriel, Nöthen, Markus M, Forstner, Andreas J, Mayr, Andreas, Krawitz, Peter, May, Patrick, Aretz, Stefan, Maj, Carlo
Format:	Report
Sprache:	eng
Schlagworte:	Analysis Care and treatment Colorectal cancer Development and progression Disease susceptibility Genetic aspects Genetic variation
Online-Zugang:	Volltext
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