Mechanical bowel preparation combined with oral antibiotics in colorectal cancer surgery: a nationwide population-based study
Background The guidelines for reducing surgical site infection in colorectal surgery recommend mechanical bowel preparation with oral antibiotics; however, this recommendation remains controversial. This study aimed to reveal the effect of oral antibiotics combined with mechanical bowel preparation...
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Veröffentlicht in: | International journal of colorectal disease 2021-09, Vol.36 (9), p.1929-1935 |
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container_issue | 9 |
container_start_page | 1929 |
container_title | International journal of colorectal disease |
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creator | Lee, Jun Ho Ahn, Byung Kyu Ryu, Jiin Lee, Kang Hong |
description | Background
The guidelines for reducing surgical site infection in colorectal surgery recommend mechanical bowel preparation with oral antibiotics; however, this recommendation remains controversial. This study aimed to reveal the effect of oral antibiotics combined with mechanical bowel preparation in colorectal surgery.
Methods
This study was a nationwide population-based retrospective study. Data between January 1, 2016, and December 31, 2018, from the Korean National Health Insurance Service database were analyzed. Patients who underwent elective colorectal cancer surgery were included.
Results
A total of 20,740 patients were finally included, comprising 14,554 (70.2%) who underwent mechanical bowel preparation alone and 6186 (29.8%) who underwent mechanical bowel preparation with oral antibiotics. The mechanical bowel preparation alone group was older than the mechanical bowel preparation with oral antibiotics group (65.7 ± 11.9 vs. 64.7 ± 11.8 years,
p
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doi_str_mv | 10.1007/s00384-021-03967-x |
format | Article |
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The guidelines for reducing surgical site infection in colorectal surgery recommend mechanical bowel preparation with oral antibiotics; however, this recommendation remains controversial. This study aimed to reveal the effect of oral antibiotics combined with mechanical bowel preparation in colorectal surgery.
Methods
This study was a nationwide population-based retrospective study. Data between January 1, 2016, and December 31, 2018, from the Korean National Health Insurance Service database were analyzed. Patients who underwent elective colorectal cancer surgery were included.
Results
A total of 20,740 patients were finally included, comprising 14,554 (70.2%) who underwent mechanical bowel preparation alone and 6186 (29.8%) who underwent mechanical bowel preparation with oral antibiotics. The mechanical bowel preparation alone group was older than the mechanical bowel preparation with oral antibiotics group (65.7 ± 11.9 vs. 64.7 ± 11.8 years,
p
< 0.001). Rectal cancer patients and patients who underwent open surgery were more likely to receive mechanical bowel preparation with oral antibiotics. Patients who underwent mechanical bowel preparation with oral antibiotics demonstrated lower surgical-site infection rate (2.9% vs. 9.4%,
p
< 0.001), shorter hospital stay (11.7 ± 5.5 vs. 13.5 ± 7.3 days,
p
< 0.001), and lower medical cost (US$7414 ± 2762 vs. US$7791 ± 3235,
p
< 0.001) than those who underwent mechanical bowel preparation alone. The 30-day readmission rates and mortality were not significantly different.
Conclusions
The use of mechanical bowel preparation with oral antibiotics reduces surgical site infection, hospital stay, and medical cost in colorectal cancer surgery.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-021-03967-x</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Antibiotics ; Cancer ; Cancer surgery ; Colorectal cancer ; Colorectal carcinoma ; Colorectal surgery ; Gastroenterology ; Hepatology ; Infection ; Infection control ; Internal Medicine ; Intestine ; Medical care, Cost of ; Medicine ; Medicine & Public Health ; Metronidazole ; National health insurance ; Oncology, Experimental ; Original Article ; Patients ; Population studies ; Population-based studies ; Proctology ; Rifaximin ; Surgery ; Surgical site infections</subject><ispartof>International journal of colorectal disease, 2021-09, Vol.36 (9), p.1929-1935</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-8db26e2398430aeb3935f1021e21ee869fc77354d4eacd2e0f772ff6e38b3aa23</citedby><cites>FETCH-LOGICAL-c419t-8db26e2398430aeb3935f1021e21ee869fc77354d4eacd2e0f772ff6e38b3aa23</cites><orcidid>0000-0003-3857-9137</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-021-03967-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-021-03967-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Lee, Jun Ho</creatorcontrib><creatorcontrib>Ahn, Byung Kyu</creatorcontrib><creatorcontrib>Ryu, Jiin</creatorcontrib><creatorcontrib>Lee, Kang Hong</creatorcontrib><title>Mechanical bowel preparation combined with oral antibiotics in colorectal cancer surgery: a nationwide population-based study</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><description>Background
The guidelines for reducing surgical site infection in colorectal surgery recommend mechanical bowel preparation with oral antibiotics; however, this recommendation remains controversial. This study aimed to reveal the effect of oral antibiotics combined with mechanical bowel preparation in colorectal surgery.
Methods
This study was a nationwide population-based retrospective study. Data between January 1, 2016, and December 31, 2018, from the Korean National Health Insurance Service database were analyzed. Patients who underwent elective colorectal cancer surgery were included.
Results
A total of 20,740 patients were finally included, comprising 14,554 (70.2%) who underwent mechanical bowel preparation alone and 6186 (29.8%) who underwent mechanical bowel preparation with oral antibiotics. The mechanical bowel preparation alone group was older than the mechanical bowel preparation with oral antibiotics group (65.7 ± 11.9 vs. 64.7 ± 11.8 years,
p
< 0.001). Rectal cancer patients and patients who underwent open surgery were more likely to receive mechanical bowel preparation with oral antibiotics. Patients who underwent mechanical bowel preparation with oral antibiotics demonstrated lower surgical-site infection rate (2.9% vs. 9.4%,
p
< 0.001), shorter hospital stay (11.7 ± 5.5 vs. 13.5 ± 7.3 days,
p
< 0.001), and lower medical cost (US$7414 ± 2762 vs. US$7791 ± 3235,
p
< 0.001) than those who underwent mechanical bowel preparation alone. The 30-day readmission rates and mortality were not significantly different.
Conclusions
The use of mechanical bowel preparation with oral antibiotics reduces surgical site infection, hospital stay, and medical cost in colorectal cancer surgery.</description><subject>Analysis</subject><subject>Antibiotics</subject><subject>Cancer</subject><subject>Cancer surgery</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal surgery</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Infection</subject><subject>Infection control</subject><subject>Internal Medicine</subject><subject>Intestine</subject><subject>Medical care, Cost of</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metronidazole</subject><subject>National health insurance</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Patients</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Proctology</subject><subject>Rifaximin</subject><subject>Surgery</subject><subject>Surgical site infections</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU9rFTEUxYMo-Kx-AVcBN25S82-SGXelWC1U3Og6ZDI3bcq8ZEwyvL5Fv7t57wlFEUkg3OR3DvfmIPSW0XNGqf5QKBW9JJQzQsWgNHl4hjZMCk4YV_w52lCmB8KGrn-JXpVyT1uttNygx6_g7mwMzs54TDuY8ZJhsdnWkCJ2aTuGCBPehXqHU26QjTWMIdXgCg4HYk4ZXG0vzkYHGZc130Lef8QWx6PLLkyAl7Ss87Ekoy3NsdR12r9GL7ydC7z5fZ6hH1efvl9-ITffPl9fXtwQJ9lQST-NXAEXQy8FtTCKQXSetWGhbejV4J3WopOTBOsmDtRrzb1XIPpRWMvFGXp_8l1y-rlCqWYbioN5thHSWgzvhFZSc9k19N1f6H1ac2zdNaobGOdCqSfq1s5gQvSpZusOpuZCMyl7TQVt1Pk_qLYm2AaXIvjQ7v8Q8JPA5VRKBm-WHLY27w2j5hC0OQVt2uzmGLR5aCJxEpUGx_b3Tx3_R_ULkXKssw</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Lee, Jun Ho</creator><creator>Ahn, Byung Kyu</creator><creator>Ryu, Jiin</creator><creator>Lee, Kang Hong</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3857-9137</orcidid></search><sort><creationdate>20210901</creationdate><title>Mechanical bowel preparation combined with oral antibiotics in colorectal cancer surgery: a nationwide population-based study</title><author>Lee, Jun Ho ; Ahn, Byung Kyu ; Ryu, Jiin ; Lee, Kang Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-8db26e2398430aeb3935f1021e21ee869fc77354d4eacd2e0f772ff6e38b3aa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Antibiotics</topic><topic>Cancer</topic><topic>Cancer surgery</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal surgery</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Infection</topic><topic>Infection control</topic><topic>Internal Medicine</topic><topic>Intestine</topic><topic>Medical care, Cost of</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metronidazole</topic><topic>National health insurance</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Patients</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Proctology</topic><topic>Rifaximin</topic><topic>Surgery</topic><topic>Surgical site infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jun Ho</creatorcontrib><creatorcontrib>Ahn, Byung Kyu</creatorcontrib><creatorcontrib>Ryu, Jiin</creatorcontrib><creatorcontrib>Lee, Kang Hong</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jun Ho</au><au>Ahn, Byung Kyu</au><au>Ryu, Jiin</au><au>Lee, Kang Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical bowel preparation combined with oral antibiotics in colorectal cancer surgery: a nationwide population-based study</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><date>2021-09-01</date><risdate>2021</risdate><volume>36</volume><issue>9</issue><spage>1929</spage><epage>1935</epage><pages>1929-1935</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Background
The guidelines for reducing surgical site infection in colorectal surgery recommend mechanical bowel preparation with oral antibiotics; however, this recommendation remains controversial. This study aimed to reveal the effect of oral antibiotics combined with mechanical bowel preparation in colorectal surgery.
Methods
This study was a nationwide population-based retrospective study. Data between January 1, 2016, and December 31, 2018, from the Korean National Health Insurance Service database were analyzed. Patients who underwent elective colorectal cancer surgery were included.
Results
A total of 20,740 patients were finally included, comprising 14,554 (70.2%) who underwent mechanical bowel preparation alone and 6186 (29.8%) who underwent mechanical bowel preparation with oral antibiotics. The mechanical bowel preparation alone group was older than the mechanical bowel preparation with oral antibiotics group (65.7 ± 11.9 vs. 64.7 ± 11.8 years,
p
< 0.001). Rectal cancer patients and patients who underwent open surgery were more likely to receive mechanical bowel preparation with oral antibiotics. Patients who underwent mechanical bowel preparation with oral antibiotics demonstrated lower surgical-site infection rate (2.9% vs. 9.4%,
p
< 0.001), shorter hospital stay (11.7 ± 5.5 vs. 13.5 ± 7.3 days,
p
< 0.001), and lower medical cost (US$7414 ± 2762 vs. US$7791 ± 3235,
p
< 0.001) than those who underwent mechanical bowel preparation alone. The 30-day readmission rates and mortality were not significantly different.
Conclusions
The use of mechanical bowel preparation with oral antibiotics reduces surgical site infection, hospital stay, and medical cost in colorectal cancer surgery.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00384-021-03967-x</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3857-9137</orcidid></addata></record> |
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subjects | Analysis Antibiotics Cancer Cancer surgery Colorectal cancer Colorectal carcinoma Colorectal surgery Gastroenterology Hepatology Infection Infection control Internal Medicine Intestine Medical care, Cost of Medicine Medicine & Public Health Metronidazole National health insurance Oncology, Experimental Original Article Patients Population studies Population-based studies Proctology Rifaximin Surgery Surgical site infections |
title | Mechanical bowel preparation combined with oral antibiotics in colorectal cancer surgery: a nationwide population-based study |
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