PI3K/AKT and MAPK1 molecular changes preceding matrix metallopeptidases overexpression during tamoxifen-resistance development are correlated to poor prognosis in breast cancer patients

Background Metastasis and drug resistance remain a persistent key clinical obstacle to the success of breast cancer treatments. Recent years have seen an increased focus on understanding the factors that influence metastasis and drug resistance. Methods In this study, the changes in MMP s gene expre...

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Veröffentlicht in:	Breast cancer (Tokyo, Japan) Japan), 2021-11, Vol.28 (6), p.1358-1366
Hauptverfasser:	Hamadneh, Lama, Bahader, Mohamad, Abuarqoub, Rama, AlWahsh, Mohammad, Alhusban, Ala, Hikmat, Suhair
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Hormonal - therapeutic use B cells Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer Cancer patients Cancer Research Care and treatment Drug resistance Drug Resistance, Neoplasm Female Gene expression Gene Expression Regulation, Neoplastic Genes Humans Life Sciences & Biomedicine Medicine Medicine & Public Health Metalloproteases - metabolism Metastasis Mitogen-Activated Protein Kinase 1 - metabolism Obstetrics & Gynecology Oncology Original Article Phosphatidylinositol 3-Kinases - metabolism Prognosis Science & Technology Surgery Surgical Oncology Tamoxifen Tamoxifen - therapeutic use
Online-Zugang:	Volltext
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