The effects of isotretinoin on the inner ear in patients with acne vulgaris/Akne vulgaris hastalarinda oral izotretinoinin kullaniminon ic kulak sistemi uzerine etkileri

Background and Design: Systemic isotretinoin (ISO) is one of the most important treatment agents that are used in nodulocystic acne treatment. It has many effects on many systems of the body. Previous studies reported positive and negative results related to systemic ISO and its effects on hearing. Thus, this study aimed to investigate the effects of systemic ISO on hearing functions. Materials and Methods: This study included 53 patients with acne vulgaris (106 ears) that were treated with 0.8 mg/kg oral ISO for 6 months. Pure tone audiometry (PTA), speech discrimination test (SD), and distortion product otoacoustic emission (DPOAE) tests were performed. Results: No significant differences were found in the mean SD and PTA threshold values between the pre- treatment period, after 3 months of treatment, and 4 months after the end of treatment. Statistically significant increases were detected in the amplitudes at 6,000, 8,000, and 10,000 Hz frequencies when DPAOE values in 3 months of treatment were compared with the pre-treatment DPAOE values; however, no significant differences were detected in the DPAOE values between the pre-treatment and 4 months after the end of treatment. Conclusion: Systemic ISO increased DPOAE amplitudes during the treatment in patients with acne; however, these changes returned to pretreatment levels in 4 months after the end of treatment. Our results indicate that ISO treatment has temporary effects on DPOAE values, which is an important parameter in measuring the cochlear function. Therefore, ISO seems a safe and well-tolerated agent for the auditory system. Keywords: Isotretinoin, acne vulgaris, inner ear Amac: Sistemik izotretinoin (ISO), nodulokistik akne tedavisinde kullanilan en onemli tedavi ajanlarindan biridir. Pek cok sistem uzerine bircok yan etkisi vardir, bunlardan biri nadiren bildirilen isitme sistemidir, ayrica onceki calismalarda sistemik ISO ve isitme sistemi uzerine etkisi ile iliskili olumlu ve olumsuz sonuclar bildirilmistir. Bu calismada sistemik ISO'nun isitme fonksiyonu uzerine olan etkilerini arastirmayi amacladik. Gerec ve Yontem: Calismaya 6 ay sureyle 0,8 mg/kg oral ISO ile tedavi edilen 53 akne vulgaris hastasi (106 kulak) dahil edildi. Saf ses odyometrisi, konusmayi ayirt etme testi (SD) ve bozulma urunu otoakustik emisyon (DPOAE) degerleri sag ve sol kulak icin ayri ayri bakilarak S ortalama degerleri alindi. Bulgular: SD ve ortalama saf ses esiklerinde (PTA) tedaviden once, tedavinin 3. ayi ve ted