Topikal Tedaviler

Topical therapies have an important place in the treatment of all acne lesions, whether mild to moderate or severe, by way of preventing development of the steps such as follicular hyperkeratinization, bacterial colonisation, and inflammation that are responsible for the pathogenesis of acne. They are frequently used as a monotherapy, part of combination regimens or with systemic antibiotics. Being effective in the treatment of both inflammatory and non-inflammatory acne lesions, topical retinoids are recommended as a first line treatment option for many acne patients. Topical antibiotics should be avoided as monotherapies due to the risk of developing bacterial resistance and should instead be used in combination therapies. Benzoyl peroxide (BPO) is an agent that is effective in inflammatory and noninflammatory acne lesions and is frequently used in combination with both systemic and topical antibiotics to prevent bacterial resistance. Besides in the treatment of acne lesions, topical retinoids, BPO, and azelaic acid in particular have a major role in the maintenance treatment to sustain the remission achieved. Keywords: Acne, azelaic acide, BPO, topical retinoids Topikal tedaviler aknenin patogenezinden sorumlu folikuler hiperkeratinizasyon, bakteriyel kolonizasyon ve enflamasyon gibi basamaklarin gelisimini onleyerek hafif-orta ya da siddetli olmak uzere tum akne lezyonlarinin tedavisinde onemli bir yere sahiptirler. Monoterapi, kombinasyon rejimleri ya da sistemik antibiyotiklerle birlikte sikca kullanilmaktadirlar. Topikal retinoidler, hem enflamatuvar hem de non-enflamatuvar akne lezyonlarinin tedavisinde etkin olmasi nedeni ile bircok akne hastasi icin birinci basamak tedavi secenegi olarak onerilmektedir. Topikal antibiyotiklerin bakteriyel direnc gelisim riski nedeni ile monoterapi olarak kullanimlarindan kacinilmali, kombinasyon tedavilerinde tercih edilmelidir. Benzoil peroksit (BPO), bakteriyel direnci onlemek icin hem sistemik hem de topikal antibiyotiklerle kombine olarak sikca kullanilan, enflamatuvar ve non-enflamatuvar akne lezyonlarinda etkili bir ajandir. Akne lezyonlarin tedavisinin yani sira elde edilen remisyonun devami icin ozellikle topikal retinoidler, BPO ve azelaik asit idame tedavide onemli bir yere sahiptir. Anahtar Kelimeler: Akne, azelaik asit, BPO, topikal retinoidler