MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis

Our recent findings link the apolipoprotein E4 ( ApoE4 )-specific changes in brain phosphoinositol biphosphate (PIP 2 ) homeostasis to the susceptibility of developing Alzheimer’s Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP 2 p...

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Veröffentlicht in:	Molecular psychiatry 2021-09, Vol.26 (9), p.4687-4701
Hauptverfasser:	Cao, Jiqing, Huang, Min, Guo, Lei, Zhu, Li, Hou, Jianwei, Zhang, Larry, Pero, Adriana, Ng, Sabrina, El Gaamouch, Farida, Elder, Gregory, Sano, Mary, Goate, Alison, TCW, Julia, Haroutunian, Vahram, Zhang, Bin, Cai, Dongming
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 13/51 13/89 14/19 38/1 38/22 38/39 38/61 38/77 45/90 631/378 64/60 692/699 82/80 Aging Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides Animals Apolipoprotein E Apolipoprotein E4 Apolipoprotein E4 - genetics Apolipoproteins Behavioral Sciences Biochemistry & Molecular Biology Biological Psychology Brain Brain stem Cerebrospinal fluid Cognition Cognitive ability Cognitive Dysfunction - genetics Development and progression Genetic aspects Health aspects Hippocampus Homeostasis Humans Inhibitory postsynaptic potentials Life Sciences & Biomedicine Lysosomes Medicine Medicine & Public Health Mice Mice, Transgenic MicroRNA MicroRNAs MicroRNAs - genetics miRNA Neurodegenerative diseases Neurosciences Neurosciences & Neurology Pharmacotherapy Phenotypes Phosphatidylinositol 4,5-diphosphate Phosphorylation Physiological aspects Pluripotency Psychiatry Science & Technology Stem cell transplantation Stem cells Tau protein
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