Metabolism by Rhizobacteria of Abscisic Acid Deuterated in the Cyclohexene Part
The required amount of abscisic acid containing 4 – 5 D atoms ([ 2 H]ABA) in the cyclohexene fragment of the molecule was produced via isotope exchange in 100% deuterated D 2 O at 220°C in the presence of diisopropyl ethylamine. The yield of labeled compound was 45 – 80%. A complex of biological stu...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2021-10, Vol.55 (7), p.745-749 |
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| creator | Yermekkaliyev, T. S. Gogoleva, N. E. Gogolev, Yu. V. Konnova, T. A. Shevchenko, V. P. Nagaev, I. Yu Shaposhnikov, A. I. Shevchenko, K. V. Belimov, A. A. Syrova, D. S. Yuzikhin, O. S. Myasoedov, N. F. |
| description | The required amount of abscisic acid containing 4 – 5 D atoms ([
2
H]ABA) in the cyclohexene fragment of the molecule was produced via isotope exchange in 100% deuterated D
2
O at 220°C in the presence of diisopropyl ethylamine. The yield of labeled compound was 45 – 80%. A complex of biological studies was carried out using the D-labeled preparation. It was established that [
2
H]ABAserved as a growth substrate for soil bacteria, which included the isotopic label in the composition of cell metabolites. The characteristics of D-labeled metabolites allowed their reliable identification in mass spectra of the total bacterial metabolome. Three intermediates of a new metabolic pathway of microbial degradation of this phytohormone were identified using the developed technique. |
| doi_str_mv | 10.1007/s11094-021-02487-w |
| format | Article |
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2
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O at 220°C in the presence of diisopropyl ethylamine. The yield of labeled compound was 45 – 80%. A complex of biological studies was carried out using the D-labeled preparation. It was established that [
2
H]ABAserved as a growth substrate for soil bacteria, which included the isotopic label in the composition of cell metabolites. The characteristics of D-labeled metabolites allowed their reliable identification in mass spectra of the total bacterial metabolome. Three intermediates of a new metabolic pathway of microbial degradation of this phytohormone were identified using the developed technique.</description><identifier>ISSN: 0091-150X</identifier><identifier>EISSN: 1573-9031</identifier><identifier>DOI: 10.1007/s11094-021-02487-w</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abscisic acid ; Chemistry, Medicinal ; Life Sciences & Biomedicine ; Medicine ; Metabolites ; Olefins ; Organic Chemistry ; Pharmacology & Pharmacy ; Pharmacology/Toxicology ; Pharmacy ; Physiological aspects ; Science & Technology ; Soil microbiology ; Tracers (Biology)</subject><ispartof>Pharmaceutical chemistry journal, 2021-10, Vol.55 (7), p.745-749</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>0</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000710310300006</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c281t-1af29a6f7af8c388cef2eaa95e9f49a7a1eec0e9992d433e6a7dbe23c632ebe33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11094-021-02487-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11094-021-02487-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,39265,41495,42564,51326</link.rule.ids></links><search><creatorcontrib>Yermekkaliyev, T. S.</creatorcontrib><creatorcontrib>Gogoleva, N. E.</creatorcontrib><creatorcontrib>Gogolev, Yu. V.</creatorcontrib><creatorcontrib>Konnova, T. A.</creatorcontrib><creatorcontrib>Shevchenko, V. P.</creatorcontrib><creatorcontrib>Nagaev, I. Yu</creatorcontrib><creatorcontrib>Shaposhnikov, A. I.</creatorcontrib><creatorcontrib>Shevchenko, K. V.</creatorcontrib><creatorcontrib>Belimov, A. A.</creatorcontrib><creatorcontrib>Syrova, D. S.</creatorcontrib><creatorcontrib>Yuzikhin, O. S.</creatorcontrib><creatorcontrib>Myasoedov, N. F.</creatorcontrib><title>Metabolism by Rhizobacteria of Abscisic Acid Deuterated in the Cyclohexene Part</title><title>Pharmaceutical chemistry journal</title><addtitle>Pharm Chem J</addtitle><addtitle>PHARM CHEM J</addtitle><description>The required amount of abscisic acid containing 4 – 5 D atoms ([
2
H]ABA) in the cyclohexene fragment of the molecule was produced via isotope exchange in 100% deuterated D
2
O at 220°C in the presence of diisopropyl ethylamine. The yield of labeled compound was 45 – 80%. A complex of biological studies was carried out using the D-labeled preparation. It was established that [
2
H]ABAserved as a growth substrate for soil bacteria, which included the isotopic label in the composition of cell metabolites. The characteristics of D-labeled metabolites allowed their reliable identification in mass spectra of the total bacterial metabolome. Three intermediates of a new metabolic pathway of microbial degradation of this phytohormone were identified using the developed technique.</description><subject>Abscisic acid</subject><subject>Chemistry, Medicinal</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine</subject><subject>Metabolites</subject><subject>Olefins</subject><subject>Organic Chemistry</subject><subject>Pharmacology & Pharmacy</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Physiological aspects</subject><subject>Science & Technology</subject><subject>Soil microbiology</subject><subject>Tracers (Biology)</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkFFrHCEQx6Uk0EvSL9An38smo97tro_HNmkLKSmlhb7JrDvmDHda1ONy-fQx3dLHEmRQxv9v0B9j7wVcCoDuKgsBetmAFLWWfdcc3rCFWHWq0aDECVsAaNGIFfx6y85yfgComJILdveVCo5x6_OOj0f-feOf4oi2UPLIo-PrMVufveVr6yf-kfb1BgtN3AdeNsSHo93GDT1SIP4NU7lgpw63md793c_Zz5vrH8Pn5vbu05dhfdtY2YvSCHRSY-s6dL1VfW_JSULUK9JuqbFDQWSBtNZyWipFLXbTSFLZVkkaSalzdjnPvcctGR9cLAltXRPtvI2BnK_9ddvL-k3RQgXkDNgUc07kzO_kd5iORoB5cWhmh6Y6NH8cmkOF-hk60BhdNUHB0j8QKiWqXlD1BO3gCxYfwxD3oVT0w-vRmlZzOtdEuKdkHuI-hWrwf897BlBVlq0</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Yermekkaliyev, T. 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2
H]ABA) in the cyclohexene fragment of the molecule was produced via isotope exchange in 100% deuterated D
2
O at 220°C in the presence of diisopropyl ethylamine. The yield of labeled compound was 45 – 80%. A complex of biological studies was carried out using the D-labeled preparation. It was established that [
2
H]ABAserved as a growth substrate for soil bacteria, which included the isotopic label in the composition of cell metabolites. The characteristics of D-labeled metabolites allowed their reliable identification in mass spectra of the total bacterial metabolome. Three intermediates of a new metabolic pathway of microbial degradation of this phytohormone were identified using the developed technique.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-021-02487-w</doi><tpages>5</tpages></addata></record> |
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| subjects | Abscisic acid Chemistry, Medicinal Life Sciences & Biomedicine Medicine Metabolites Olefins Organic Chemistry Pharmacology & Pharmacy Pharmacology/Toxicology Pharmacy Physiological aspects Science & Technology Soil microbiology Tracers (Biology) |
| title | Metabolism by Rhizobacteria of Abscisic Acid Deuterated in the Cyclohexene Part |
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