MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

MAP4K4 is a Ste20 member and reported to play important roles in various pathologies, including in cancer. However, the mechanism by which MAP4K4 promotes pancreatic cancer is not fully understood. It is suggested that MAP4K4 might function as a cancer promoter via specific downstream target(s) in a...

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Veröffentlicht in:	Oncogene 2021-10, Vol.40 (43), p.6153-6165
Hauptverfasser:	Singh, Sunil Kumar, Kumar, Sandeep, Viswakarma, Navin, Principe, Daniel R., Das, Subhasis, Sondarva, Gautam, Nair, Rakesh Sathish, Srivastava, Piush, Sinha, Subhash C., Grippo, Paul J., Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/1 14/105 631/67/1504/1713 631/80/86/2366 64/110 82/29 96/106 96/109 96/2 96/31 96/95 Animals Apoptosis Biochemistry & Molecular Biology Cell Biology Cell cycle Cell death Cell growth Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Development and progression Disease Progression Gene Expression Regulation, Neoplastic Genetics & Heredity Health aspects HEK293 Cells Human Genetics Humans Internal Medicine Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Kinases Life Sciences & Biomedicine MAP kinase MAP kinase kinase MAP Kinase Kinase Kinases - metabolism Medicine Medicine & Public Health Mice Mitogen-Activated Protein Kinase Kinase Kinase 11 Mitogen-activated protein kinases Neoplasm Transplantation Oncology Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phosphorylation Physiological aspects Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - metabolism Science & Technology Stroma Threonine - chemistry Tumorigenesis Tumors Up-Regulation
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