Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage

Gene expression is highly variable across tissues of multi-cellular organisms, influencing the codon usage of the tissue-specific transcriptome. Cancer disrupts the gene expression pattern of healthy tissue resulting in altered codon usage preferences. The topic of codon usage changes as they relate...

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Veröffentlicht in:	Genome medicine 2021-07, Vol.13 (1), p.122-122, Article 122
Hauptverfasser:	Meyer, Douglas, Kames, Jacob, Bar, Haim, Komar, Anton A, Alexaki, Aikaterini, Ibla, Juan, Hunt, Ryan C, Santana-Quintero, Luis V, Golikov, Anton, DiCuccio, Michael, Kimchi-Sarfaty, Chava
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biomarkers, Tumor Breast Breast cancer Cancer Cancer research Cancer transcriptome CancerCoCoPUTs Codon Codon pair Codon Usage Computational Biology - methods Databases, Genetic Development and progression Drug development E coli Efficiency Epidermal growth factor Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic aspects Genome-Wide Association Study Genomes Genomics Genomics - methods Glycine Humans Invasiveness Kaplan-Meier Estimate Medical prognosis Metadata Mutation Neoplasms - diagnosis Neoplasms - genetics Neoplasms - mortality Patients Prognosis Relative synonymous codon usage (RSCU) Solid tumors Survival analysis The Cancer Genome Atlas (TCGA) Transcriptome Transcriptomes Transfer RNA tRNA Tumors Use statistics Vaccines
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