Long noncoding RNA uc003pxg.1 regulates endothelial cell proliferation and migration via miR‑25‑5p in coronary artery disease
Long noncoding RNAs (lncRNAs) have been reported to be associated with the progression of coronary artery disease (CAD). In our previous study, the levels of lncRNA were upregulated in patients with CAD compared with those in control subjects. However, the role and underlying mechanism of the effect...
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| Veröffentlicht in: | International journal of molecular medicine 2021-08, Vol.48 (2), p.1, Article 160 |
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| creator | Li, Ping Li, Yuan Chen, Lu Ma, Xuexing Yan, Xinxin Yan, Meina Qian, Buyun Wang, Feng Xu, Jingyi Yin, Juan Xu, Guidong Sun, Kangyun |
| description | Long noncoding RNAs (lncRNAs) have been reported to be associated with the progression of coronary artery disease (CAD). In our previous study, the levels of lncRNA
were upregulated in patients with CAD compared with those in control subjects. However, the role and underlying mechanism of the effects of
in CAD remain unknown. Therefore, the aim of the present study was to investigate the expression pattern and biological function of
in CAD. First,
expression levels were assessed in peripheral blood mononuclear cells isolated from patients with CAD by reverse transcription‑quantitative (RT‑q)PCR. The results demonstrated that the levels of
were significantly upregulated (~4.6‑fold) in samples from 80 patients with CAD compared with those in 80 healthy subjects. Subsequently, the present study demonstrated that small interfering RNA‑mediated
knockdown inhibited human umbilical vein endothelial cell (HUVEC) proliferation and migration, which was analyzed using the Cell Counting Kit‑8, cell cycle, EdU and Transwell assays. Additionally, the results of RT‑qPCR and western blot analyses revealed that
regulated the mRNA and protein levels of cyclin D1 and cyclin‑dependent kinase. Through high‑throughput sequencing and dual‑luciferase reporter assays, the present study demonstrated that microRNA (miR)‑25‑5p was a downstream target of
. Further experiments verified that
regulated HUVEC proliferation and migration via
. The results of the present study may enhance the current understanding of the role of lncRNA
in CAD. |
| doi_str_mv | 10.3892/ijmm.2021.4993 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_gale_infotracacademiconefile_A669679417</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A669679417</galeid><sourcerecordid>A669679417</sourcerecordid><originalsourceid>FETCH-LOGICAL-c485t-80a41d3aa0e838349d119fcb9f83d8ec547a9a272cc2c757cb3bce2536f4ce0a3</originalsourceid><addsrcrecordid>eNptUk1r3DAQFaWhSdNeeyyCnu3qy7Z0KSyhX7A0EFroTWjlsaPFllzJDu0t-Qn9i_0llel2SSAINDPSm8eT5iH0ipKSS8Xeuv04lowwWgql-BN0RhtFCybE96c5p6QpeFPVp-h5SntCWCWUfIZOuWCUKcnP0N02-B774G1oXc6uvmzwYgnh08--pDhCvwxmhoTBt2G-hsGZAVsYBjzFMLgOopld8Nj4Fo-uP1Q3zuTq6s_tb1blrZqw89iGGLyJv7CJM-TQugQmwQt00pkhwctDPEffPrz_evGp2F5-_Hyx2RZWyGouJDGCttwYApJLLlRLqersTnWStxJsJRqjDGuYtcw2VWN3fGeBVbzuhAVi-Dl69493WnYjtBb8HM2gp-jGLEoH4_TDG--udR9utGQ1q2uaCd4cCGL4sUCa9T4s0WfNev3XmjGVR3BE9WYA7XwXMpkdXbJ6U9eqbpSgTUaVj6DyamF0NnjoXD5_rMHGkFKE7iicEr06Qa9O0KsT9OqE3PD6_nOP8P-j538BQU6yfw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2549622999</pqid></control><display><type>article</type><title>Long noncoding RNA uc003pxg.1 regulates endothelial cell proliferation and migration via miR‑25‑5p in coronary artery disease</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Li, Ping ; Li, Yuan ; Chen, Lu ; Ma, Xuexing ; Yan, Xinxin ; Yan, Meina ; Qian, Buyun ; Wang, Feng ; Xu, Jingyi ; Yin, Juan ; Xu, Guidong ; Sun, Kangyun</creator><creatorcontrib>Li, Ping ; Li, Yuan ; Chen, Lu ; Ma, Xuexing ; Yan, Xinxin ; Yan, Meina ; Qian, Buyun ; Wang, Feng ; Xu, Jingyi ; Yin, Juan ; Xu, Guidong ; Sun, Kangyun</creatorcontrib><description>Long noncoding RNAs (lncRNAs) have been reported to be associated with the progression of coronary artery disease (CAD). In our previous study, the levels of lncRNA
were upregulated in patients with CAD compared with those in control subjects. However, the role and underlying mechanism of the effects of
in CAD remain unknown. Therefore, the aim of the present study was to investigate the expression pattern and biological function of
in CAD. First,
expression levels were assessed in peripheral blood mononuclear cells isolated from patients with CAD by reverse transcription‑quantitative (RT‑q)PCR. The results demonstrated that the levels of
were significantly upregulated (~4.6‑fold) in samples from 80 patients with CAD compared with those in 80 healthy subjects. Subsequently, the present study demonstrated that small interfering RNA‑mediated
knockdown inhibited human umbilical vein endothelial cell (HUVEC) proliferation and migration, which was analyzed using the Cell Counting Kit‑8, cell cycle, EdU and Transwell assays. Additionally, the results of RT‑qPCR and western blot analyses revealed that
regulated the mRNA and protein levels of cyclin D1 and cyclin‑dependent kinase. Through high‑throughput sequencing and dual‑luciferase reporter assays, the present study demonstrated that microRNA (miR)‑25‑5p was a downstream target of
. Further experiments verified that
regulated HUVEC proliferation and migration via
. The results of the present study may enhance the current understanding of the role of lncRNA
in CAD.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.2021.4993</identifier><identifier>PMID: 34212983</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis ; Anticoagulants ; Antisense RNA ; Apoptosis ; Atherosclerosis ; Base Sequence ; Biotechnology industry ; Blood pressure ; Cancer ; Cardiovascular disease ; Cell cycle ; Cell Cycle - genetics ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cell growth ; Cell Movement - genetics ; Cell Proliferation - genetics ; Cells, Cultured ; Coronary Artery Disease - genetics ; Coronary Artery Disease - metabolism ; Coronary Artery Disease - pathology ; Coronary heart disease ; Coronary vessels ; Cyclin-dependent kinases ; Development and progression ; Disease prevention ; Endothelium ; Ethylenediaminetetraacetic acid ; Female ; Gene expression ; Gene Expression Profiling - methods ; Human Umbilical Vein Endothelial Cells - metabolism ; Humans ; Kinases ; Male ; Medical research ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; Plasma ; RNA, Long Noncoding - genetics ; RNA-Seq - methods ; Scientific equipment and supplies industry ; Sequence Homology, Nucleic Acid</subject><ispartof>International journal of molecular medicine, 2021-08, Vol.48 (2), p.1, Article 160</ispartof><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright: © Li et al. 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-80a41d3aa0e838349d119fcb9f83d8ec547a9a272cc2c757cb3bce2536f4ce0a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34212983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Chen, Lu</creatorcontrib><creatorcontrib>Ma, Xuexing</creatorcontrib><creatorcontrib>Yan, Xinxin</creatorcontrib><creatorcontrib>Yan, Meina</creatorcontrib><creatorcontrib>Qian, Buyun</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Xu, Jingyi</creatorcontrib><creatorcontrib>Yin, Juan</creatorcontrib><creatorcontrib>Xu, Guidong</creatorcontrib><creatorcontrib>Sun, Kangyun</creatorcontrib><title>Long noncoding RNA uc003pxg.1 regulates endothelial cell proliferation and migration via miR‑25‑5p in coronary artery disease</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>Long noncoding RNAs (lncRNAs) have been reported to be associated with the progression of coronary artery disease (CAD). In our previous study, the levels of lncRNA
were upregulated in patients with CAD compared with those in control subjects. However, the role and underlying mechanism of the effects of
in CAD remain unknown. Therefore, the aim of the present study was to investigate the expression pattern and biological function of
in CAD. First,
expression levels were assessed in peripheral blood mononuclear cells isolated from patients with CAD by reverse transcription‑quantitative (RT‑q)PCR. The results demonstrated that the levels of
were significantly upregulated (~4.6‑fold) in samples from 80 patients with CAD compared with those in 80 healthy subjects. Subsequently, the present study demonstrated that small interfering RNA‑mediated
knockdown inhibited human umbilical vein endothelial cell (HUVEC) proliferation and migration, which was analyzed using the Cell Counting Kit‑8, cell cycle, EdU and Transwell assays. Additionally, the results of RT‑qPCR and western blot analyses revealed that
regulated the mRNA and protein levels of cyclin D1 and cyclin‑dependent kinase. Through high‑throughput sequencing and dual‑luciferase reporter assays, the present study demonstrated that microRNA (miR)‑25‑5p was a downstream target of
. Further experiments verified that
regulated HUVEC proliferation and migration via
. The results of the present study may enhance the current understanding of the role of lncRNA
in CAD.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Anticoagulants</subject><subject>Antisense RNA</subject><subject>Apoptosis</subject><subject>Atherosclerosis</subject><subject>Base Sequence</subject><subject>Biotechnology industry</subject><subject>Blood pressure</subject><subject>Cancer</subject><subject>Cardiovascular disease</subject><subject>Cell cycle</subject><subject>Cell Cycle - genetics</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell growth</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Cells, Cultured</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Cyclin-dependent kinases</subject><subject>Development and progression</subject><subject>Disease prevention</subject><subject>Endothelium</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Human Umbilical Vein Endothelial Cells - metabolism</subject><subject>Humans</subject><subject>Kinases</subject><subject>Male</subject><subject>Medical research</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA-Seq - methods</subject><subject>Scientific equipment and supplies industry</subject><subject>Sequence Homology, Nucleic Acid</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptUk1r3DAQFaWhSdNeeyyCnu3qy7Z0KSyhX7A0EFroTWjlsaPFllzJDu0t-Qn9i_0llel2SSAINDPSm8eT5iH0ipKSS8Xeuv04lowwWgql-BN0RhtFCybE96c5p6QpeFPVp-h5SntCWCWUfIZOuWCUKcnP0N02-B774G1oXc6uvmzwYgnh08--pDhCvwxmhoTBt2G-hsGZAVsYBjzFMLgOopld8Nj4Fo-uP1Q3zuTq6s_tb1blrZqw89iGGLyJv7CJM-TQugQmwQt00pkhwctDPEffPrz_evGp2F5-_Hyx2RZWyGouJDGCttwYApJLLlRLqersTnWStxJsJRqjDGuYtcw2VWN3fGeBVbzuhAVi-Dl69493WnYjtBb8HM2gp-jGLEoH4_TDG--udR9utGQ1q2uaCd4cCGL4sUCa9T4s0WfNev3XmjGVR3BE9WYA7XwXMpkdXbJ6U9eqbpSgTUaVj6DyamF0NnjoXD5_rMHGkFKE7iicEr06Qa9O0KsT9OqE3PD6_nOP8P-j538BQU6yfw</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Li, Ping</creator><creator>Li, Yuan</creator><creator>Chen, Lu</creator><creator>Ma, Xuexing</creator><creator>Yan, Xinxin</creator><creator>Yan, Meina</creator><creator>Qian, Buyun</creator><creator>Wang, Feng</creator><creator>Xu, Jingyi</creator><creator>Yin, Juan</creator><creator>Xu, Guidong</creator><creator>Sun, Kangyun</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20210801</creationdate><title>Long noncoding RNA uc003pxg.1 regulates endothelial cell proliferation and migration via miR‑25‑5p in coronary artery disease</title><author>Li, Ping ; Li, Yuan ; Chen, Lu ; Ma, Xuexing ; Yan, Xinxin ; Yan, Meina ; Qian, Buyun ; Wang, Feng ; Xu, Jingyi ; Yin, Juan ; Xu, Guidong ; Sun, Kangyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-80a41d3aa0e838349d119fcb9f83d8ec547a9a272cc2c757cb3bce2536f4ce0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Anticoagulants</topic><topic>Antisense RNA</topic><topic>Apoptosis</topic><topic>Atherosclerosis</topic><topic>Base Sequence</topic><topic>Biotechnology industry</topic><topic>Blood pressure</topic><topic>Cancer</topic><topic>Cardiovascular disease</topic><topic>Cell cycle</topic><topic>Cell Cycle - genetics</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell growth</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation - genetics</topic><topic>Cells, Cultured</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Cyclin-dependent kinases</topic><topic>Development and progression</topic><topic>Disease prevention</topic><topic>Endothelium</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Human Umbilical Vein Endothelial Cells - metabolism</topic><topic>Humans</topic><topic>Kinases</topic><topic>Male</topic><topic>Medical research</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Plasma</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA-Seq - methods</topic><topic>Scientific equipment and supplies industry</topic><topic>Sequence Homology, Nucleic Acid</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Chen, Lu</creatorcontrib><creatorcontrib>Ma, Xuexing</creatorcontrib><creatorcontrib>Yan, Xinxin</creatorcontrib><creatorcontrib>Yan, Meina</creatorcontrib><creatorcontrib>Qian, Buyun</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Xu, Jingyi</creatorcontrib><creatorcontrib>Yin, Juan</creatorcontrib><creatorcontrib>Xu, Guidong</creatorcontrib><creatorcontrib>Sun, Kangyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ping</au><au>Li, Yuan</au><au>Chen, Lu</au><au>Ma, Xuexing</au><au>Yan, Xinxin</au><au>Yan, Meina</au><au>Qian, Buyun</au><au>Wang, Feng</au><au>Xu, Jingyi</au><au>Yin, Juan</au><au>Xu, Guidong</au><au>Sun, Kangyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long noncoding RNA uc003pxg.1 regulates endothelial cell proliferation and migration via miR‑25‑5p in coronary artery disease</atitle><jtitle>International journal of molecular medicine</jtitle><addtitle>Int J Mol Med</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>48</volume><issue>2</issue><spage>1</spage><pages>1-</pages><artnum>160</artnum><issn>1107-3756</issn><eissn>1791-244X</eissn><abstract>Long noncoding RNAs (lncRNAs) have been reported to be associated with the progression of coronary artery disease (CAD). In our previous study, the levels of lncRNA
were upregulated in patients with CAD compared with those in control subjects. However, the role and underlying mechanism of the effects of
in CAD remain unknown. Therefore, the aim of the present study was to investigate the expression pattern and biological function of
in CAD. First,
expression levels were assessed in peripheral blood mononuclear cells isolated from patients with CAD by reverse transcription‑quantitative (RT‑q)PCR. The results demonstrated that the levels of
were significantly upregulated (~4.6‑fold) in samples from 80 patients with CAD compared with those in 80 healthy subjects. Subsequently, the present study demonstrated that small interfering RNA‑mediated
knockdown inhibited human umbilical vein endothelial cell (HUVEC) proliferation and migration, which was analyzed using the Cell Counting Kit‑8, cell cycle, EdU and Transwell assays. Additionally, the results of RT‑qPCR and western blot analyses revealed that
regulated the mRNA and protein levels of cyclin D1 and cyclin‑dependent kinase. Through high‑throughput sequencing and dual‑luciferase reporter assays, the present study demonstrated that microRNA (miR)‑25‑5p was a downstream target of
. Further experiments verified that
regulated HUVEC proliferation and migration via
. The results of the present study may enhance the current understanding of the role of lncRNA
in CAD.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>34212983</pmid><doi>10.3892/ijmm.2021.4993</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of molecular medicine, 2021-08, Vol.48 (2), p.1, Article 160 |
| issn | 1107-3756 1791-244X |
| language | eng |
| recordid | cdi_gale_infotracacademiconefile_A669679417 |
| source | Spandidos Publications Journals; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Aged Aged, 80 and over Analysis Anticoagulants Antisense RNA Apoptosis Atherosclerosis Base Sequence Biotechnology industry Blood pressure Cancer Cardiovascular disease Cell cycle Cell Cycle - genetics Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell growth Cell Movement - genetics Cell Proliferation - genetics Cells, Cultured Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Coronary heart disease Coronary vessels Cyclin-dependent kinases Development and progression Disease prevention Endothelium Ethylenediaminetetraacetic acid Female Gene expression Gene Expression Profiling - methods Human Umbilical Vein Endothelial Cells - metabolism Humans Kinases Male Medical research MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged Plasma RNA, Long Noncoding - genetics RNA-Seq - methods Scientific equipment and supplies industry Sequence Homology, Nucleic Acid |
| title | Long noncoding RNA uc003pxg.1 regulates endothelial cell proliferation and migration via miR‑25‑5p in coronary artery disease |
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