Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children
Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children. S K Jain , R McVie and T Smith Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport 71130, USA. sjain@lsum.edu Abstract OBJECTIV...
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| Veröffentlicht in: | Diabetes care 2000-09, Vol.23 (9), p.1389-1394 |
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| description | Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic
children.
S K Jain ,
R McVie and
T Smith
Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport 71130, USA. sjain@lsum.edu
Abstract
OBJECTIVE: This study examined the relationship between cellular glutathione and vitamin E concentrations and the effect of
vitamin E (alpha-tocopherol) supplementation on glutathione and lipid peroxidation product concentrations in the erythrocytes
of type 1 diabetic patients. RESEARCH DESIGN AND METHODS: We obtained written informed consent to participate in this study
from diabetic patients (n = 29) and their age-matched nondiabetic siblings (n = 21) according to the guidelines of the Institutional
Review Board on Human Experimentation. Diabetic patients were supplemented with a DL-alpha-tocopherol (vitamin E) capsule
(100 IU/orally) or placebo for 3 months in a double-blind clinical trial. Fasting blood samples were collected from each diabetic
patient before the start of and after the 3 months of vitamin E or placebo supplementation. Glutathione, malondialdehyde (which
is a product of lipid peroxidation), and alpha-tocopherol were determined using high-performance liquid chromatography A total
of 5 diabetic patients were excluded after randomization from the data analyses. Data were analyzed statistically using a
paired Students t test to compare 12 diabetic patients taking vitamin E with 12 diabetic patients receiving placebo supplementation
and to compare diabetic patients with healthy nondiabetic subjects. RESULTS: Erythrocytes of diabetic patients had 21% higher
(P |
| doi_str_mv | 10.2337/diacare.23.9.1389 |
| format | Article |
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children.
S K Jain ,
R McVie and
T Smith
Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport 71130, USA. sjain@lsum.edu
Abstract
OBJECTIVE: This study examined the relationship between cellular glutathione and vitamin E concentrations and the effect of
vitamin E (alpha-tocopherol) supplementation on glutathione and lipid peroxidation product concentrations in the erythrocytes
of type 1 diabetic patients. RESEARCH DESIGN AND METHODS: We obtained written informed consent to participate in this study
from diabetic patients (n = 29) and their age-matched nondiabetic siblings (n = 21) according to the guidelines of the Institutional
Review Board on Human Experimentation. Diabetic patients were supplemented with a DL-alpha-tocopherol (vitamin E) capsule
(100 IU/orally) or placebo for 3 months in a double-blind clinical trial. Fasting blood samples were collected from each diabetic
patient before the start of and after the 3 months of vitamin E or placebo supplementation. Glutathione, malondialdehyde (which
is a product of lipid peroxidation), and alpha-tocopherol were determined using high-performance liquid chromatography A total
of 5 diabetic patients were excluded after randomization from the data analyses. Data were analyzed statistically using a
paired Students t test to compare 12 diabetic patients taking vitamin E with 12 diabetic patients receiving placebo supplementation
and to compare diabetic patients with healthy nondiabetic subjects. RESULTS: Erythrocytes of diabetic patients had 21% higher
(P<0.001) malondialdehyde and 15% lower (P<0.05) glutathione concentrations than healthy subjects. Vitamin E in erythrocytes
had a significant correlation with the glutathione concentrations in the erythrocytes (r = 0.46, P<0.02). Vitamin E supplementation
increased glutathione concentrations by 9% (P<0.01) and lowered concentrations of malondialdehyde by 23% (P<0.001) and of
HbA1c by 16% (P<0.02) in erythrocytes of diabetic patients. No differences were evident in these parameters before versus
after placebo supplementation. CONCLUSIONS: Glutathione level is significantly related to vitamin E level, and supplementation
with vitamin E (100 IU/day) significantly increases glutathione and lowers lipid peroxidation and HbA1c concentrations in
the erythrocytes of type 1 diabetic patients.]]></description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/diacare.23.9.1389</identifier><identifier>PMID: 10977039</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Associated diseases and complications ; Biological and medical sciences ; Child ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes. Impaired glucose tolerance ; Diet therapy ; Dietary Supplements ; Double-Blind Method ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Erythrocytes - metabolism ; Glutathione - blood ; Health aspects ; Humans ; Lipid Peroxidation ; Malondialdehyde - blood ; Medical sciences ; Placebos ; Reference Values ; Regression Analysis ; Type 1 diabetes ; Vitamin E ; Vitamin E - blood ; Vitamin E - pharmacology ; Vitamin E - therapeutic use</subject><ispartof>Diabetes care, 2000-09, Vol.23 (9), p.1389-1394</ispartof><rights>2000 INIST-CNRS</rights><rights>COPYRIGHT 2000 American Diabetes Association</rights><rights>Copyright American Diabetes Association Sep 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-2b92af62181c4b7d56f31550cf29521572e2da20718802133a080f7ccb8d6ea33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1482270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10977039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JAIN, S. K</creatorcontrib><creatorcontrib>MCVIE, R</creatorcontrib><creatorcontrib>SMITH, T</creatorcontrib><title>Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description><![CDATA[Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic
children.
S K Jain ,
R McVie and
T Smith
Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport 71130, USA. sjain@lsum.edu
Abstract
OBJECTIVE: This study examined the relationship between cellular glutathione and vitamin E concentrations and the effect of
vitamin E (alpha-tocopherol) supplementation on glutathione and lipid peroxidation product concentrations in the erythrocytes
of type 1 diabetic patients. RESEARCH DESIGN AND METHODS: We obtained written informed consent to participate in this study
from diabetic patients (n = 29) and their age-matched nondiabetic siblings (n = 21) according to the guidelines of the Institutional
Review Board on Human Experimentation. Diabetic patients were supplemented with a DL-alpha-tocopherol (vitamin E) capsule
(100 IU/orally) or placebo for 3 months in a double-blind clinical trial. Fasting blood samples were collected from each diabetic
patient before the start of and after the 3 months of vitamin E or placebo supplementation. Glutathione, malondialdehyde (which
is a product of lipid peroxidation), and alpha-tocopherol were determined using high-performance liquid chromatography A total
of 5 diabetic patients were excluded after randomization from the data analyses. Data were analyzed statistically using a
paired Students t test to compare 12 diabetic patients taking vitamin E with 12 diabetic patients receiving placebo supplementation
and to compare diabetic patients with healthy nondiabetic subjects. RESULTS: Erythrocytes of diabetic patients had 21% higher
(P<0.001) malondialdehyde and 15% lower (P<0.05) glutathione concentrations than healthy subjects. Vitamin E in erythrocytes
had a significant correlation with the glutathione concentrations in the erythrocytes (r = 0.46, P<0.02). Vitamin E supplementation
increased glutathione concentrations by 9% (P<0.01) and lowered concentrations of malondialdehyde by 23% (P<0.001) and of
HbA1c by 16% (P<0.02) in erythrocytes of diabetic patients. No differences were evident in these parameters before versus
after placebo supplementation. CONCLUSIONS: Glutathione level is significantly related to vitamin E level, and supplementation
with vitamin E (100 IU/day) significantly increases glutathione and lowers lipid peroxidation and HbA1c concentrations in
the erythrocytes of type 1 diabetic patients.]]></description><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet therapy</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Erythrocytes - metabolism</subject><subject>Glutathione - blood</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lipid Peroxidation</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Placebos</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Type 1 diabetes</subject><subject>Vitamin E</subject><subject>Vitamin E - blood</subject><subject>Vitamin E - pharmacology</subject><subject>Vitamin E - therapeutic use</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkt2K1TAQx4Mo7vHoA3gjQcQLscd8NG1zuSzrByx4o96WNJ2eZmmTmrQsfQJf2zn2gCKHQMIMv_nPTGYIecnZQUhZfmidsSYCGgd94LLSj8iOa6kypfLqMdkxnutMaS2uyLOU7hljeV5VT8kVZ7osmdQ78uuHm83oPL2laZmmAUbws5ld8DRCmgNe9Dgs6OrRB9T4lo5mCB5zDy30awt0DtSHiF5qg7cYH_8IJIqyENe5j8GuMwqFjs7rBJRTjG5gdpba3g1tBP-cPOnMkODF-d2T7x9vv918zu6-fvpyc32XWcWKORONFqYrBK-4zZuyVUUnuVLMdkIrwVUpQLRGsJJXFRNcSsMq1pXWNlVbgJFyT95uulMMPxfssB5dsjAMxkNYUl0KIZVmOYKv_wPvwxI91lYjwooyL0qE3m_Q0QxQO98F7N0ewUM8_RF0Dt3XhSoUKhaIZxdwPC2Mzl7i-cbbGFKK0NVTdKOJa81ZfdqA-rwBaNS6Pm0Axrw61700I7T_RGwjR-DNGTDJmqGLxluX_nJ5JQSCe_Juw3p37B8c5thmBulC0t9Uusrh</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>JAIN, S. K</creator><creator>MCVIE, R</creator><creator>SMITH, T</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children</title><author>JAIN, S. K ; MCVIE, R ; SMITH, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-2b92af62181c4b7d56f31550cf29521572e2da20718802133a080f7ccb8d6ea33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet therapy</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Erythrocytes - metabolism</topic><topic>Glutathione - blood</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lipid Peroxidation</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Placebos</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Type 1 diabetes</topic><topic>Vitamin E</topic><topic>Vitamin E - blood</topic><topic>Vitamin E - pharmacology</topic><topic>Vitamin E - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JAIN, S. K</creatorcontrib><creatorcontrib>MCVIE, R</creatorcontrib><creatorcontrib>SMITH, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JAIN, S. K</au><au>MCVIE, R</au><au>SMITH, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>23</volume><issue>9</issue><spage>1389</spage><epage>1394</epage><pages>1389-1394</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract><![CDATA[Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic
children.
S K Jain ,
R McVie and
T Smith
Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport 71130, USA. sjain@lsum.edu
Abstract
OBJECTIVE: This study examined the relationship between cellular glutathione and vitamin E concentrations and the effect of
vitamin E (alpha-tocopherol) supplementation on glutathione and lipid peroxidation product concentrations in the erythrocytes
of type 1 diabetic patients. RESEARCH DESIGN AND METHODS: We obtained written informed consent to participate in this study
from diabetic patients (n = 29) and their age-matched nondiabetic siblings (n = 21) according to the guidelines of the Institutional
Review Board on Human Experimentation. Diabetic patients were supplemented with a DL-alpha-tocopherol (vitamin E) capsule
(100 IU/orally) or placebo for 3 months in a double-blind clinical trial. Fasting blood samples were collected from each diabetic
patient before the start of and after the 3 months of vitamin E or placebo supplementation. Glutathione, malondialdehyde (which
is a product of lipid peroxidation), and alpha-tocopherol were determined using high-performance liquid chromatography A total
of 5 diabetic patients were excluded after randomization from the data analyses. Data were analyzed statistically using a
paired Students t test to compare 12 diabetic patients taking vitamin E with 12 diabetic patients receiving placebo supplementation
and to compare diabetic patients with healthy nondiabetic subjects. RESULTS: Erythrocytes of diabetic patients had 21% higher
(P<0.001) malondialdehyde and 15% lower (P<0.05) glutathione concentrations than healthy subjects. Vitamin E in erythrocytes
had a significant correlation with the glutathione concentrations in the erythrocytes (r = 0.46, P<0.02). Vitamin E supplementation
increased glutathione concentrations by 9% (P<0.01) and lowered concentrations of malondialdehyde by 23% (P<0.001) and of
HbA1c by 16% (P<0.02) in erythrocytes of diabetic patients. No differences were evident in these parameters before versus
after placebo supplementation. CONCLUSIONS: Glutathione level is significantly related to vitamin E level, and supplementation
with vitamin E (100 IU/day) significantly increases glutathione and lowers lipid peroxidation and HbA1c concentrations in
the erythrocytes of type 1 diabetic patients.]]></abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>10977039</pmid><doi>10.2337/diacare.23.9.1389</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2000-09, Vol.23 (9), p.1389-1394 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_gale_infotracacademiconefile_A65650436 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Associated diseases and complications Biological and medical sciences Child Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes. Impaired glucose tolerance Diet therapy Dietary Supplements Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinopathies Erythrocytes - metabolism Glutathione - blood Health aspects Humans Lipid Peroxidation Malondialdehyde - blood Medical sciences Placebos Reference Values Regression Analysis Type 1 diabetes Vitamin E Vitamin E - blood Vitamin E - pharmacology Vitamin E - therapeutic use |
| title | Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children |
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