Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis

Aim: To analyze the late-stage failures of monoclonal antibody drugs. The later a drug fails in development, the more time and expense is incurred by the sponsor. Methods: We review the late stage, Phase III, failures of 21 monoclonal antibody drugs between 2014 and 2019 using published and publicly...

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Veröffentlicht in:	Pharmacology 2020-03, Vol.105 (3-4), p.145-163
Hauptverfasser:	Sun, Amy, Benet, Leslie Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Clinical trials Clinical Trials, Phase III as Topic - methods Drug Development - economics Drug Development - methods Humans Management Monoclonal antibodies Patient outcomes Pharmacology, Experimental Retrospective Studies Review Article Treatment Failure
Online-Zugang:	Volltext
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