Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS
Background Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical significance in patients with pneumonia-related ARDS is unknown. This study aime...
Gespeichert in:
| Veröffentlicht in: | Critical Care 2021, Vol.25 (1) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Report |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | |
| container_title | Critical Care |
| container_volume | 25 |
| creator | Bendib, Inès Beldi-Ferchiou, Asma Schlemmer, Frédéric Surenaud, Mathieu Maitre, Bernard Plonquet, Anne Carteaux, Guillaume Razazi, Keyvan Godot, Veronique Hüe, Sophie Mekontso Dessap, Armand de Prost, Nicolas |
| description | Background Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical significance in patients with pneumonia-related ARDS is unknown. This study aimed at assessing the interrelation of ARDS/sepsis biomarkers in the alveolar and blood compartments and explored their association with clinical outcomes. Methods Immunocompetent patients with pneumonia-related ARDS admitted between 2014 and 2018 were included in a prospective monocentric study. Bronchoalveolar lavage (BAL) fluid and blood samples were obtained within 48 h of admission. Twenty-two biomarkers were quantified in BAL fluid and serum. HLA-DR.sup.+ monocytes and CD8.sup.+ PD-1.sup.+ lymphocytes were quantified using flow cytometry. The primary clinical endpoint of the study was hospital mortality. Patients undergoing a bronchoscopy as part of routine care were included as controls. Results Seventy ARDS patients were included. Hospital mortality was 21.4%. The BAL fluid-to-serum ratio of IL-8 was 20 times higher in ARDS patients than in controls (p < 0.0001). ARDS patients with shock had lower BAL fluid-to-serum ratio of IL-1Ra (p = 0.026), IL-6 (p = 0.002), IP-10/CXCL10 (p = 0.024) and IL-10 (p = 0.023) than others. The BAL fluid-to-serum ratio of IL-1Ra was more elevated in hospital survivors than decedents (p = 0.006), even after adjusting for SOFA and driving pressure (p = 0.036). There was no significant association between alveolar or alveolar/blood monocytic HLA-DR or CD8.sup.+ lymphocytes PD-1 expression and hospital mortality. Conclusions IL-8 was the most compartmentalized cytokine and lower BAL fluid-to-serum concentration ratios of IL-1Ra were associated with hospital mortality in patients with pneumonia-associated ARDS. Keywords: Respiratory distress syndrome, Adult, Pneumonia, Cytokines, HLA-DR antigens, PD-1 |
| doi_str_mv | 10.1186/s13054-020-03427-y |
| format | Report |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracacademiconefile_A650601651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A650601651</galeid><sourcerecordid>A650601651</sourcerecordid><originalsourceid>FETCH-gale_infotracacademiconefile_A6506016513</originalsourceid><addsrcrecordid>eNqVjEtOAzEQRL0AKeFzAVa-gIMdj53ZjviINbBHnZmeyNDtjmwHKZyeWXABVIuSnuqVUnfObpzr43113obO2K011nfbnTlfqLXzsTN98GGlrmr9tNbt-ujXaj_QNwpB0aPwEUpjzA0o_UBLkrXMOuWZgBmalLOGPOnEfMqoRyTS-yQM5QtLXXb6mPHEkhOYggQNJz28Pr7dqMsZqOLtX1-rzfPT-8OLOQDhx3IvrcC4ZEJOo2Sc08KHGGy0Lgbn_y38AuGOU8I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>report</recordtype></control><display><type>report</type><title>Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS</title><source>Springer Nature - Complete Springer Journals</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Springer Nature OA Free Journals</source><creator>Bendib, Inès ; Beldi-Ferchiou, Asma ; Schlemmer, Frédéric ; Surenaud, Mathieu ; Maitre, Bernard ; Plonquet, Anne ; Carteaux, Guillaume ; Razazi, Keyvan ; Godot, Veronique ; Hüe, Sophie ; Mekontso Dessap, Armand ; de Prost, Nicolas</creator><creatorcontrib>Bendib, Inès ; Beldi-Ferchiou, Asma ; Schlemmer, Frédéric ; Surenaud, Mathieu ; Maitre, Bernard ; Plonquet, Anne ; Carteaux, Guillaume ; Razazi, Keyvan ; Godot, Veronique ; Hüe, Sophie ; Mekontso Dessap, Armand ; de Prost, Nicolas</creatorcontrib><description>Background Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical significance in patients with pneumonia-related ARDS is unknown. This study aimed at assessing the interrelation of ARDS/sepsis biomarkers in the alveolar and blood compartments and explored their association with clinical outcomes. Methods Immunocompetent patients with pneumonia-related ARDS admitted between 2014 and 2018 were included in a prospective monocentric study. Bronchoalveolar lavage (BAL) fluid and blood samples were obtained within 48 h of admission. Twenty-two biomarkers were quantified in BAL fluid and serum. HLA-DR.sup.+ monocytes and CD8.sup.+ PD-1.sup.+ lymphocytes were quantified using flow cytometry. The primary clinical endpoint of the study was hospital mortality. Patients undergoing a bronchoscopy as part of routine care were included as controls. Results Seventy ARDS patients were included. Hospital mortality was 21.4%. The BAL fluid-to-serum ratio of IL-8 was 20 times higher in ARDS patients than in controls (p < 0.0001). ARDS patients with shock had lower BAL fluid-to-serum ratio of IL-1Ra (p = 0.026), IL-6 (p = 0.002), IP-10/CXCL10 (p = 0.024) and IL-10 (p = 0.023) than others. The BAL fluid-to-serum ratio of IL-1Ra was more elevated in hospital survivors than decedents (p = 0.006), even after adjusting for SOFA and driving pressure (p = 0.036). There was no significant association between alveolar or alveolar/blood monocytic HLA-DR or CD8.sup.+ lymphocytes PD-1 expression and hospital mortality. Conclusions IL-8 was the most compartmentalized cytokine and lower BAL fluid-to-serum concentration ratios of IL-1Ra were associated with hospital mortality in patients with pneumonia-associated ARDS. Keywords: Respiratory distress syndrome, Adult, Pneumonia, Cytokines, HLA-DR antigens, PD-1</description><identifier>ISSN: 1364-8535</identifier><identifier>DOI: 10.1186/s13054-020-03427-y</identifier><language>eng</language><publisher>BioMed Central Ltd</publisher><subject>Acute respiratory distress syndrome ; Bacterial pneumonia ; Biological markers ; Blood cells ; Complications and side effects ; Cytokines ; Health aspects ; Histocompatibility antigens ; HLA histocompatibility antigens ; Measurement ; Patient outcomes ; Pneumonia ; Prognosis</subject><ispartof>Critical Care, 2021, Vol.25 (1)</ispartof><rights>COPYRIGHT 2021 BioMed Central Ltd.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,780,860,4476,27902</link.rule.ids></links><search><creatorcontrib>Bendib, Inès</creatorcontrib><creatorcontrib>Beldi-Ferchiou, Asma</creatorcontrib><creatorcontrib>Schlemmer, Frédéric</creatorcontrib><creatorcontrib>Surenaud, Mathieu</creatorcontrib><creatorcontrib>Maitre, Bernard</creatorcontrib><creatorcontrib>Plonquet, Anne</creatorcontrib><creatorcontrib>Carteaux, Guillaume</creatorcontrib><creatorcontrib>Razazi, Keyvan</creatorcontrib><creatorcontrib>Godot, Veronique</creatorcontrib><creatorcontrib>Hüe, Sophie</creatorcontrib><creatorcontrib>Mekontso Dessap, Armand</creatorcontrib><creatorcontrib>de Prost, Nicolas</creatorcontrib><title>Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS</title><title>Critical Care</title><description>Background Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical significance in patients with pneumonia-related ARDS is unknown. This study aimed at assessing the interrelation of ARDS/sepsis biomarkers in the alveolar and blood compartments and explored their association with clinical outcomes. Methods Immunocompetent patients with pneumonia-related ARDS admitted between 2014 and 2018 were included in a prospective monocentric study. Bronchoalveolar lavage (BAL) fluid and blood samples were obtained within 48 h of admission. Twenty-two biomarkers were quantified in BAL fluid and serum. HLA-DR.sup.+ monocytes and CD8.sup.+ PD-1.sup.+ lymphocytes were quantified using flow cytometry. The primary clinical endpoint of the study was hospital mortality. Patients undergoing a bronchoscopy as part of routine care were included as controls. Results Seventy ARDS patients were included. Hospital mortality was 21.4%. The BAL fluid-to-serum ratio of IL-8 was 20 times higher in ARDS patients than in controls (p < 0.0001). ARDS patients with shock had lower BAL fluid-to-serum ratio of IL-1Ra (p = 0.026), IL-6 (p = 0.002), IP-10/CXCL10 (p = 0.024) and IL-10 (p = 0.023) than others. The BAL fluid-to-serum ratio of IL-1Ra was more elevated in hospital survivors than decedents (p = 0.006), even after adjusting for SOFA and driving pressure (p = 0.036). There was no significant association between alveolar or alveolar/blood monocytic HLA-DR or CD8.sup.+ lymphocytes PD-1 expression and hospital mortality. Conclusions IL-8 was the most compartmentalized cytokine and lower BAL fluid-to-serum concentration ratios of IL-1Ra were associated with hospital mortality in patients with pneumonia-associated ARDS. Keywords: Respiratory distress syndrome, Adult, Pneumonia, Cytokines, HLA-DR antigens, PD-1</description><subject>Acute respiratory distress syndrome</subject><subject>Bacterial pneumonia</subject><subject>Biological markers</subject><subject>Blood cells</subject><subject>Complications and side effects</subject><subject>Cytokines</subject><subject>Health aspects</subject><subject>Histocompatibility antigens</subject><subject>HLA histocompatibility antigens</subject><subject>Measurement</subject><subject>Patient outcomes</subject><subject>Pneumonia</subject><subject>Prognosis</subject><issn>1364-8535</issn><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2021</creationdate><recordtype>report</recordtype><sourceid/><recordid>eNqVjEtOAzEQRL0AKeFzAVa-gIMdj53ZjviINbBHnZmeyNDtjmwHKZyeWXABVIuSnuqVUnfObpzr43113obO2K011nfbnTlfqLXzsTN98GGlrmr9tNbt-ujXaj_QNwpB0aPwEUpjzA0o_UBLkrXMOuWZgBmalLOGPOnEfMqoRyTS-yQM5QtLXXb6mPHEkhOYggQNJz28Pr7dqMsZqOLtX1-rzfPT-8OLOQDhx3IvrcC4ZEJOo2Sc08KHGGy0Lgbn_y38AuGOU8I</recordid><startdate>20210109</startdate><enddate>20210109</enddate><creator>Bendib, Inès</creator><creator>Beldi-Ferchiou, Asma</creator><creator>Schlemmer, Frédéric</creator><creator>Surenaud, Mathieu</creator><creator>Maitre, Bernard</creator><creator>Plonquet, Anne</creator><creator>Carteaux, Guillaume</creator><creator>Razazi, Keyvan</creator><creator>Godot, Veronique</creator><creator>Hüe, Sophie</creator><creator>Mekontso Dessap, Armand</creator><creator>de Prost, Nicolas</creator><general>BioMed Central Ltd</general><scope/></search><sort><creationdate>20210109</creationdate><title>Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS</title><author>Bendib, Inès ; Beldi-Ferchiou, Asma ; Schlemmer, Frédéric ; Surenaud, Mathieu ; Maitre, Bernard ; Plonquet, Anne ; Carteaux, Guillaume ; Razazi, Keyvan ; Godot, Veronique ; Hüe, Sophie ; Mekontso Dessap, Armand ; de Prost, Nicolas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_infotracacademiconefile_A6506016513</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute respiratory distress syndrome</topic><topic>Bacterial pneumonia</topic><topic>Biological markers</topic><topic>Blood cells</topic><topic>Complications and side effects</topic><topic>Cytokines</topic><topic>Health aspects</topic><topic>Histocompatibility antigens</topic><topic>HLA histocompatibility antigens</topic><topic>Measurement</topic><topic>Patient outcomes</topic><topic>Pneumonia</topic><topic>Prognosis</topic><toplevel>online_resources</toplevel><creatorcontrib>Bendib, Inès</creatorcontrib><creatorcontrib>Beldi-Ferchiou, Asma</creatorcontrib><creatorcontrib>Schlemmer, Frédéric</creatorcontrib><creatorcontrib>Surenaud, Mathieu</creatorcontrib><creatorcontrib>Maitre, Bernard</creatorcontrib><creatorcontrib>Plonquet, Anne</creatorcontrib><creatorcontrib>Carteaux, Guillaume</creatorcontrib><creatorcontrib>Razazi, Keyvan</creatorcontrib><creatorcontrib>Godot, Veronique</creatorcontrib><creatorcontrib>Hüe, Sophie</creatorcontrib><creatorcontrib>Mekontso Dessap, Armand</creatorcontrib><creatorcontrib>de Prost, Nicolas</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bendib, Inès</au><au>Beldi-Ferchiou, Asma</au><au>Schlemmer, Frédéric</au><au>Surenaud, Mathieu</au><au>Maitre, Bernard</au><au>Plonquet, Anne</au><au>Carteaux, Guillaume</au><au>Razazi, Keyvan</au><au>Godot, Veronique</au><au>Hüe, Sophie</au><au>Mekontso Dessap, Armand</au><au>de Prost, Nicolas</au><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><atitle>Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS</atitle><jtitle>Critical Care</jtitle><date>2021-01-09</date><risdate>2021</risdate><volume>25</volume><issue>1</issue><issn>1364-8535</issn><abstract>Background Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical significance in patients with pneumonia-related ARDS is unknown. This study aimed at assessing the interrelation of ARDS/sepsis biomarkers in the alveolar and blood compartments and explored their association with clinical outcomes. Methods Immunocompetent patients with pneumonia-related ARDS admitted between 2014 and 2018 were included in a prospective monocentric study. Bronchoalveolar lavage (BAL) fluid and blood samples were obtained within 48 h of admission. Twenty-two biomarkers were quantified in BAL fluid and serum. HLA-DR.sup.+ monocytes and CD8.sup.+ PD-1.sup.+ lymphocytes were quantified using flow cytometry. The primary clinical endpoint of the study was hospital mortality. Patients undergoing a bronchoscopy as part of routine care were included as controls. Results Seventy ARDS patients were included. Hospital mortality was 21.4%. The BAL fluid-to-serum ratio of IL-8 was 20 times higher in ARDS patients than in controls (p < 0.0001). ARDS patients with shock had lower BAL fluid-to-serum ratio of IL-1Ra (p = 0.026), IL-6 (p = 0.002), IP-10/CXCL10 (p = 0.024) and IL-10 (p = 0.023) than others. The BAL fluid-to-serum ratio of IL-1Ra was more elevated in hospital survivors than decedents (p = 0.006), even after adjusting for SOFA and driving pressure (p = 0.036). There was no significant association between alveolar or alveolar/blood monocytic HLA-DR or CD8.sup.+ lymphocytes PD-1 expression and hospital mortality. Conclusions IL-8 was the most compartmentalized cytokine and lower BAL fluid-to-serum concentration ratios of IL-1Ra were associated with hospital mortality in patients with pneumonia-associated ARDS. Keywords: Respiratory distress syndrome, Adult, Pneumonia, Cytokines, HLA-DR antigens, PD-1</abstract><pub>BioMed Central Ltd</pub><doi>10.1186/s13054-020-03427-y</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1364-8535 |
| ispartof | Critical Care, 2021, Vol.25 (1) |
| issn | 1364-8535 |
| language | eng |
| recordid | cdi_gale_infotracacademiconefile_A650601651 |
| source | Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA Free Journals |
| subjects | Acute respiratory distress syndrome Bacterial pneumonia Biological markers Blood cells Complications and side effects Cytokines Health aspects Histocompatibility antigens HLA histocompatibility antigens Measurement Patient outcomes Pneumonia Prognosis |
| title | Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T19%3A53%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.atitle=Alveolar%20compartmentalization%20of%20inflammatory%20and%20immune%20cell%20biomarkers%20in%20pneumonia-related%20ARDS&rft.jtitle=Critical%20Care&rft.au=Bendib,%20In%C3%A8s&rft.date=2021-01-09&rft.volume=25&rft.issue=1&rft.issn=1364-8535&rft_id=info:doi/10.1186/s13054-020-03427-y&rft_dat=%3Cgale%3EA650601651%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A650601651&rfr_iscdi=true |