Cortisone and cortisol break hydrogen-bonding rules to make a drug-prodrug solid solution

Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoich...

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Veröffentlicht in:	IUCrJ 2020-11, Vol.7 (Pt 6), p.1124-1130
Hauptverfasser:	Verma, Vivek, Bordignon, Simone, Chierotti, Michele R, Lestari, Monica, Lyons, Kieran, Padrela, Luis, Ryan, Kevin M, Lusi, Matteo
Format:	Artikel
Sprache:	eng
Schlagworte:	assisted spray drying Cortisone Hydrocortisone Hydrogen Hydrogen bonding Hydrogen bonds mixed crystals multidrug formulations pharmaceutical solids Research Papers Securities law Solid solutions Spray drying steroids Stoichiometry
Online-Zugang:	Volltext
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