T Cell Activation Machinery: Form and Function in Natural and Engineered Immune Receptors

The impressive success of chimeric antigen receptor (CAR)-T cell therapies in treating advanced B-cell malignancies has spurred a frenzy of activity aimed at developing CAR-T therapies for other cancers, particularly solid tumors, and optimizing engineered T cells for maximum clinical benefit in man...

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Veröffentlicht in:	International journal of molecular sciences 2020-10, Vol.21 (19), p.7424, Article 7424
Hauptverfasser:	Chandler, Nicholas J., Call, Melissa J., Call, Matthew E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Antigens, Neoplasm - immunology Biochemistry & Molecular Biology CAR Cell activation Cell Communication - immunology Cell Engineering - methods Chemistry Chemistry, Multidisciplinary chimeric antigen receptor Chimeric antigen receptors Cytokines Health aspects Humans Immune system Immunoglobulins immunoreceptor Immunotherapy Immunotherapy, Adoptive - methods Life Sciences & Biomedicine Ligands Lymphocyte Activation - immunology Lymphocytes Lymphocytes B Lymphocytes T Neoplasms - therapy Peptides Physical Sciences Protein Domains Proteins Receptor mechanisms Receptors, Chimeric Antigen - chemistry Receptors, Chimeric Antigen - immunology Review Science & Technology Signal transduction Solid tumors structure Structure-function relationships T cell T cell receptors T cells T-Lymphocytes - immunology
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