Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection

Clearance of acute infection with hepatitis C virus (HCV) is associated with the chr19q13.13 region containing the rs368234815 (TT/ΔG) polymorphism. We fine-mapped this region to detect possible causal variants that may contribute to HCV clearance. First, we performed sequencing of IFNL1-IFNL4 regio...

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Veröffentlicht in:	Genes and immunity 2020-11, Vol.21 (5), p.348-359
Hauptverfasser:	Vergara, Candelaria, Duggal, Priya, Thio, Chloe L., Valencia, Ana, O’Brien, Thomas R., Latanich, Rachel, Timp, Winston, Johnson, Eric O., Kral, Alex H., Mangia, Alessandra, Goedert, James J., Piazzola, Valeria, Mehta, Shruti H., Kirk, Gregory D., Peters, Marion G., Donfield, Sharyne M., Edlin, Brian R., Busch, Michael P., Alexander, Graeme, Murphy, Edward L., Kim, Arthur Y., Lauer, Georg M., Chung, Raymond T., Cramp, Matthew E., Cox, Andrea L., Khakoo, Salim I., Rosen, Hugo R., Alric, Laurent, Wheelan, Sarah J., Wojcik, Genevieve L., Thomas, David L., Taub, Margaret A.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/23 45/43 631/208/205/2138 631/208/248/144 631/250/254 Analysis Association analysis Biomedical and Life Sciences Biomedicine Black People - genetics Cancer Research Gene Expression Gene polymorphism Genetic aspects Genetic polymorphisms Haplotypes Health aspects Hepatitis Hepatitis C Hepatitis C - ethnology Hepatitis C - genetics Hepatitis C - pathology Host-virus relationships Human Genetics Humans Immunology Interferon Interferons - genetics Life Sciences Patient outcomes Phenotype Polymorphism, Single Nucleotide Single-nucleotide polymorphism White People - genetics
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