Fungal Co-infections Associated with Global COVID-19 Pandemic: A Clinical and Diagnostic Perspective from China

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been sweeping across the globe. Based on a retrospective analysis of SARS and influenza data from China and worldwide, we surmise that the fungal co-infections associated with global COVI...

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Veröffentlicht in:Mycopathologia (1975) 2020-08, Vol.185 (4), p.599-606
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description Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been sweeping across the globe. Based on a retrospective analysis of SARS and influenza data from China and worldwide, we surmise that the fungal co-infections associated with global COVID-19 might be missed or misdiagnosed. Although there are few publications, COVID-19 patients, especially severely ill or immunocompromised, have a higher probability of suffering from invasive mycoses. Aspergillus and Candida infections in COVID-19 patients will require early detection by a comprehensive diagnostic intervention (histopathology, direct microscopic examination, culture, (1,3)- β - d -glucan, galactomannan, and PCR-based assays) to ensure effective treatments. We suggest it is prudent to assess the risk factors, the types of invasive mycosis, the strengths and limitations of diagnostic methods, clinical settings, and the need for standard or individualized treatment in COVID-19 patients. We provide a clinical flow diagram to assist the clinicians and laboratory experts in the management of aspergillosis, candidiasis, mucormycosis, or cryptococcosis as co-morbidities in COVID-19 patients.
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Liang, Guanzhao ; Liu, Weida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-bc7c6d8bc6b0a8965860642bde4eb8b38402c673b2974e10d9a6d7368cb368413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antifungal agents</topic><topic>Aspergillosis</topic><topic>Biomedical and Life Sciences</topic><topic>Candidiasis</topic><topic>Candidiasis, Invasive - complications</topic><topic>Candidiasis, Invasive - diagnosis</topic><topic>Candidiasis, Invasive - therapy</topic><topic>Caspofungin</topic><topic>China</topic><topic>Coronavirus Infections - complications</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cryptococcosis</topic><topic>Cryptococcosis - complications</topic><topic>Cryptococcosis - diagnosis</topic><topic>Cryptococcosis - therapy</topic><topic>Editorial</topic><topic>Eukaryotic Microbiology</topic><topic>Fungal infections</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infections</topic><topic>Influenza</topic><topic>Invasive Pulmonary Aspergillosis - complications</topic><topic>Invasive Pulmonary Aspergillosis - diagnosis</topic><topic>Invasive Pulmonary Aspergillosis - therapy</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Methenamine</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Molds (Fungi)</topic><topic>Mucormycosis</topic><topic>Mucormycosis - complications</topic><topic>Mucormycosis - diagnosis</topic><topic>Mucormycosis - therapy</topic><topic>Mycoses</topic><topic>Mycoses - complications</topic><topic>Mycoses - diagnosis</topic><topic>Mycoses - therapy</topic><topic>Mycosis</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Plant Sciences</topic><topic>Pneumonia, Viral - complications</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Risk factors</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Ge</creatorcontrib><creatorcontrib>Liang, Guanzhao</creatorcontrib><creatorcontrib>Liu, Weida</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; 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subjects Antifungal agents
Aspergillosis
Biomedical and Life Sciences
Candidiasis
Candidiasis, Invasive - complications
Candidiasis, Invasive - diagnosis
Candidiasis, Invasive - therapy
Caspofungin
China
Coronavirus Infections - complications
Coronavirus Infections - diagnosis
Coronaviruses
COVID-19
Cryptococcosis
Cryptococcosis - complications
Cryptococcosis - diagnosis
Cryptococcosis - therapy
Editorial
Eukaryotic Microbiology
Fungal infections
Health aspects
Humans
Infections
Influenza
Invasive Pulmonary Aspergillosis - complications
Invasive Pulmonary Aspergillosis - diagnosis
Invasive Pulmonary Aspergillosis - therapy
Life Sciences
Medical Microbiology
Medical research
Medicine, Experimental
Methenamine
Microbial Ecology
Microbiology
Molds (Fungi)
Mucormycosis
Mucormycosis - complications
Mucormycosis - diagnosis
Mucormycosis - therapy
Mycoses
Mycoses - complications
Mycoses - diagnosis
Mycoses - therapy
Mycosis
Pandemics
Patients
Plant Sciences
Pneumonia, Viral - complications
Pneumonia, Viral - diagnosis
Risk factors
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
title Fungal Co-infections Associated with Global COVID-19 Pandemic: A Clinical and Diagnostic Perspective from China
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