Role of microRNA-33a in malignant cells
Cancer causes most of the mortality and morbidity worldwide, with a significant increase in incidence during recent years. MicroRNAs (miRNAs/miRs) are non-coding small RNAs capable of regulating gene expression. They regulate crucial cellular processes, including proliferation, differentiation, meta...
Gespeichert in:
| Veröffentlicht in: | Oncology letters 2020-09, Vol.20 (3), p.2537-2556 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2556 |
|---|---|
| container_issue | 3 |
| container_start_page | 2537 |
| container_title | Oncology letters |
| container_volume | 20 |
| creator | Gao, Chang Wei, Jiaen Tang, Tingting Huang, Zunnan |
| description | Cancer causes most of the mortality and morbidity worldwide, with a significant increase in incidence during recent years. MicroRNAs (miRNAs/miRs) are non-coding small RNAs capable of regulating gene expression. They regulate crucial cellular processes, including proliferation, differentiation, metastasis and apoptosis. Therefore, abnormal miRNA expression is associated with multiple diseases, including cancer. There are two types of cancer-associated miRNAs, oncogenic and tumor suppressor miRNAs, depending on their roles and expression patterns in cancer. Accordingly, miRNAs are considered to be targets for cancer prevention and treatment. miR-33a controls cellular cholesterol uptake and synthesis, which are both closely associated with carcinogenesis. The present review thoroughly describes the roles of miR-33a in more than a dozen types of cancer and the underlying mechanisms. Accordingly, the present review may serve as a guide for researchers studying the involvement of miR-33a in diverse cancer settings. |
| doi_str_mv | 10.3892/ol.2020.11835 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_gale_infotracacademiconefile_A633565331</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A633565331</galeid><sourcerecordid>A633565331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c556t-83716855f0529cd7f77388801b232abe600a2e4c9358a534de2ee8145193ca3a3</originalsourceid><addsrcrecordid>eNqNkcFrHCEUxqW0NCHNsfeBQnMIs1XfOOolsCxNUggthPYsrvtm1-BoMs609L-Pmw2bLuRQPfjQ3_ep7yPkI6MzUJp_SWHGKaczxhSIN-SYSc1rRhV_u69lc0ROc76jZYiWKdW-J0fApeJC8mNydpsCVqmreu-GdPt9XgPYyseqt8Gvo41j5TCE_IG862zIePq8npBfl19_Lq7rmx9X3xbzm9oJ0Y61AslaJURHBdduJTspQSlF2ZIDt0tsKbUcG6dBKCugWSFHVKwRTIOzYOGEXOx876dljyuHcRxsMPeD7-3w1yTrzeFJ9BuzTr-NBK2laovBp2eDIT1MmEdzl6Yhljcb3gAHzRrJX6i1DWh87FIxc73PzsxbANEKAFao2StUmSss7UoRO1_2DwSf_xFs0IZxk1OYRp9iPgTrHVianvOA3f6HjJpttCYFs43WPEVbeLXj_-Ayddl5jA73mqdoQYOCbcUXfrTbGxdpimORnv-_FB4BwjmwMw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2432391472</pqid></control><display><type>article</type><title>Role of microRNA-33a in malignant cells</title><source>Spandidos Publications Journals</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Gao, Chang ; Wei, Jiaen ; Tang, Tingting ; Huang, Zunnan</creator><creatorcontrib>Gao, Chang ; Wei, Jiaen ; Tang, Tingting ; Huang, Zunnan</creatorcontrib><description>Cancer causes most of the mortality and morbidity worldwide, with a significant increase in incidence during recent years. MicroRNAs (miRNAs/miRs) are non-coding small RNAs capable of regulating gene expression. They regulate crucial cellular processes, including proliferation, differentiation, metastasis and apoptosis. Therefore, abnormal miRNA expression is associated with multiple diseases, including cancer. There are two types of cancer-associated miRNAs, oncogenic and tumor suppressor miRNAs, depending on their roles and expression patterns in cancer. Accordingly, miRNAs are considered to be targets for cancer prevention and treatment. miR-33a controls cellular cholesterol uptake and synthesis, which are both closely associated with carcinogenesis. The present review thoroughly describes the roles of miR-33a in more than a dozen types of cancer and the underlying mechanisms. Accordingly, the present review may serve as a guide for researchers studying the involvement of miR-33a in diverse cancer settings.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2020.11835</identifier><identifier>PMID: 32782572</identifier><language>eng</language><publisher>ATHENS: Spandidos Publ Ltd</publisher><subject>Apoptosis ; Breast cancer ; Cancer prevention ; Cell cycle ; Cholesterol ; Cyclin-dependent kinases ; Digestive system ; Gastric cancer ; Gene expression ; Genes ; Health aspects ; Kinases ; Leukemia ; Life Sciences & Biomedicine ; Liver cancer ; Lung cancer ; Medical prognosis ; MicroRNA ; MicroRNAs ; Mortality ; Oncology ; Prostate ; Proteins ; Review ; Science & Technology ; Transcription factors ; Tumorigenesis ; Tumors</subject><ispartof>Oncology letters, 2020-09, Vol.20 (3), p.2537-2556</ispartof><rights>COPYRIGHT 2020 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2020</rights><rights>Copyright: © Gao et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>13</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000563938300052</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c556t-83716855f0529cd7f77388801b232abe600a2e4c9358a534de2ee8145193ca3a3</citedby><cites>FETCH-LOGICAL-c556t-83716855f0529cd7f77388801b232abe600a2e4c9358a534de2ee8145193ca3a3</cites><orcidid>0000-0002-5821-703X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399786/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399786/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,28253,53796,53798</link.rule.ids></links><search><creatorcontrib>Gao, Chang</creatorcontrib><creatorcontrib>Wei, Jiaen</creatorcontrib><creatorcontrib>Tang, Tingting</creatorcontrib><creatorcontrib>Huang, Zunnan</creatorcontrib><title>Role of microRNA-33a in malignant cells</title><title>Oncology letters</title><addtitle>ONCOL LETT</addtitle><description>Cancer causes most of the mortality and morbidity worldwide, with a significant increase in incidence during recent years. MicroRNAs (miRNAs/miRs) are non-coding small RNAs capable of regulating gene expression. They regulate crucial cellular processes, including proliferation, differentiation, metastasis and apoptosis. Therefore, abnormal miRNA expression is associated with multiple diseases, including cancer. There are two types of cancer-associated miRNAs, oncogenic and tumor suppressor miRNAs, depending on their roles and expression patterns in cancer. Accordingly, miRNAs are considered to be targets for cancer prevention and treatment. miR-33a controls cellular cholesterol uptake and synthesis, which are both closely associated with carcinogenesis. The present review thoroughly describes the roles of miR-33a in more than a dozen types of cancer and the underlying mechanisms. Accordingly, the present review may serve as a guide for researchers studying the involvement of miR-33a in diverse cancer settings.</description><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>Cancer prevention</subject><subject>Cell cycle</subject><subject>Cholesterol</subject><subject>Cyclin-dependent kinases</subject><subject>Digestive system</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Kinases</subject><subject>Leukemia</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Prostate</subject><subject>Proteins</subject><subject>Review</subject><subject>Science & Technology</subject><subject>Transcription factors</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkcFrHCEUxqW0NCHNsfeBQnMIs1XfOOolsCxNUggthPYsrvtm1-BoMs609L-Pmw2bLuRQPfjQ3_ep7yPkI6MzUJp_SWHGKaczxhSIN-SYSc1rRhV_u69lc0ROc76jZYiWKdW-J0fApeJC8mNydpsCVqmreu-GdPt9XgPYyseqt8Gvo41j5TCE_IG862zIePq8npBfl19_Lq7rmx9X3xbzm9oJ0Y61AslaJURHBdduJTspQSlF2ZIDt0tsKbUcG6dBKCugWSFHVKwRTIOzYOGEXOx876dljyuHcRxsMPeD7-3w1yTrzeFJ9BuzTr-NBK2laovBp2eDIT1MmEdzl6Yhljcb3gAHzRrJX6i1DWh87FIxc73PzsxbANEKAFao2StUmSss7UoRO1_2DwSf_xFs0IZxk1OYRp9iPgTrHVianvOA3f6HjJpttCYFs43WPEVbeLXj_-Ayddl5jA73mqdoQYOCbcUXfrTbGxdpimORnv-_FB4BwjmwMw</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Gao, Chang</creator><creator>Wei, Jiaen</creator><creator>Tang, Tingting</creator><creator>Huang, Zunnan</creator><general>Spandidos Publ Ltd</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5821-703X</orcidid></search><sort><creationdate>20200901</creationdate><title>Role of microRNA-33a in malignant cells</title><author>Gao, Chang ; Wei, Jiaen ; Tang, Tingting ; Huang, Zunnan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-83716855f0529cd7f77388801b232abe600a2e4c9358a534de2ee8145193ca3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>Cancer prevention</topic><topic>Cell cycle</topic><topic>Cholesterol</topic><topic>Cyclin-dependent kinases</topic><topic>Digestive system</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Health aspects</topic><topic>Kinases</topic><topic>Leukemia</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver cancer</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>Mortality</topic><topic>Oncology</topic><topic>Prostate</topic><topic>Proteins</topic><topic>Review</topic><topic>Science & Technology</topic><topic>Transcription factors</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Gao, Chang</creatorcontrib><creatorcontrib>Wei, Jiaen</creatorcontrib><creatorcontrib>Tang, Tingting</creatorcontrib><creatorcontrib>Huang, Zunnan</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Chang</au><au>Wei, Jiaen</au><au>Tang, Tingting</au><au>Huang, Zunnan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of microRNA-33a in malignant cells</atitle><jtitle>Oncology letters</jtitle><stitle>ONCOL LETT</stitle><date>2020-09-01</date><risdate>2020</risdate><volume>20</volume><issue>3</issue><spage>2537</spage><epage>2556</epage><pages>2537-2556</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Cancer causes most of the mortality and morbidity worldwide, with a significant increase in incidence during recent years. MicroRNAs (miRNAs/miRs) are non-coding small RNAs capable of regulating gene expression. They regulate crucial cellular processes, including proliferation, differentiation, metastasis and apoptosis. Therefore, abnormal miRNA expression is associated with multiple diseases, including cancer. There are two types of cancer-associated miRNAs, oncogenic and tumor suppressor miRNAs, depending on their roles and expression patterns in cancer. Accordingly, miRNAs are considered to be targets for cancer prevention and treatment. miR-33a controls cellular cholesterol uptake and synthesis, which are both closely associated with carcinogenesis. The present review thoroughly describes the roles of miR-33a in more than a dozen types of cancer and the underlying mechanisms. Accordingly, the present review may serve as a guide for researchers studying the involvement of miR-33a in diverse cancer settings.</abstract><cop>ATHENS</cop><pub>Spandidos Publ Ltd</pub><pmid>32782572</pmid><doi>10.3892/ol.2020.11835</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-5821-703X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1792-1074 |
| ispartof | Oncology letters, 2020-09, Vol.20 (3), p.2537-2556 |
| issn | 1792-1074 1792-1082 |
| language | eng |
| recordid | cdi_gale_infotracacademiconefile_A633565331 |
| source | Spandidos Publications Journals; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Apoptosis Breast cancer Cancer prevention Cell cycle Cholesterol Cyclin-dependent kinases Digestive system Gastric cancer Gene expression Genes Health aspects Kinases Leukemia Life Sciences & Biomedicine Liver cancer Lung cancer Medical prognosis MicroRNA MicroRNAs Mortality Oncology Prostate Proteins Review Science & Technology Transcription factors Tumorigenesis Tumors |
| title | Role of microRNA-33a in malignant cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T12%3A41%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20microRNA-33a%20in%20malignant%20cells&rft.jtitle=Oncology%20letters&rft.au=Gao,%20Chang&rft.date=2020-09-01&rft.volume=20&rft.issue=3&rft.spage=2537&rft.epage=2556&rft.pages=2537-2556&rft.issn=1792-1074&rft.eissn=1792-1082&rft_id=info:doi/10.3892/ol.2020.11835&rft_dat=%3Cgale_proqu%3EA633565331%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2432391472&rft_id=info:pmid/32782572&rft_galeid=A633565331&rfr_iscdi=true |