Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains

The growth of the malaria parasite Plasmodium falciparum in human blood causes all the symptoms of malaria. To proliferate, non-motile parasites must have access to susceptible red blood cells, which they invade using pairs of parasite ligands and host receptors that define invasion pathways. Parasi...

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Veröffentlicht in:	PLoS computational biology 2020-04, Vol.16 (4), p.e1007702-e1007702, Article 1007702
Hauptverfasser:	Cai, Francisco Y., DeSimone, Tiffany M., Hansen, Elsa, Jennings, Cameron V., Bei, Amy K., Ahouidi, Ambroise D., Mboup, Souleymane, Duraisingh, Manoj T., Buckee, Caroline O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accessibility Age Analysis Animals Bacteriology Biochemical Research Methods Biochemistry & Molecular Biology Biological invasions Biology and Life Sciences Blood Blood cells Cell proliferation Cytology Diagnosis Distribution Ecology Epidemiology Erythrocyte Count Erythrocytes Erythrocytes - parasitology Erythrocytes - physiology Growth Heterogeneity Humans Immune Evasion - genetics Immune Evasion - immunology Immunology Infections Infectious diseases Laboratories Life Sciences & Biomedicine Ligands Malaria Malaria - parasitology Malaria, Falciparum - parasitology Mathematical & Computational Biology Mathematical models Medicine and Health Sciences Models, Theoretical Parasites Pathways Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - pathogenicity Public health Receptor density Receptors Red blood cell count Red blood cells Science & Technology Software Vector-borne diseases Virology Virulence
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