TADs without borders

TADs without borders

Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light...

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Veröffentlicht in:Nature genetics 2020-08, Vol.52 (8), p.752-753
Hauptverfasser: Farabella, Irene, Marti-Renom, Marc A.
Format: Artikel
Sprache:eng
Schlagworte:
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Agriculture
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Borders
Boundaries
Cancer Research
Cell Cycle Proteins
Chromatin
Chromosomal Proteins, Non-Histone
Cohesin
Cohesins
Cohesion
Depletion
Experiments
Gene expression
Gene Function
Genes
Genetics & Heredity
Genomes
Genomics
Human Genetics
Life Sciences & Biomedicine
Microscopy
News & Views
news-and-views
Permeability
Population
Reforming
Roles
Science & Technology
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Beschreibung
Zusammenfassung:Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene regulation.
ISSN:1061-4036
1546-1718
DOI:10.1038/s41588-020-0670-x