Resveratrol attenuates angiotensin II-induced cellular hypertrophy through the inhibition of CYP1B1 and the cardiotoxic mid-chain HETE metabolites

Several reports demonstrated the direct contribution of cytochrome P450 1B1 (CYP1B1) enzyme and its associated cardiotoxic mid-chain, hydroxyeicosatetraenoic acid (HETEs) metabolites in the development of cardiac hypertrophy. Resveratrol is commercially available polyphenol that exerts beneficial ef...

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Veröffentlicht in:	Molecular and cellular biochemistry 2020-08, Vol.471 (1-2), p.165-176
Hauptverfasser:	Shoieb, Sherif M., El-Kadi, Ayman O. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiotensin Angiotensin II Angiotensin II - adverse effects Antioxidants - pharmacology Atrial Natriuretic Factor - metabolism Atrial natriuretic peptide Attenuation Biochemistry Biomedical and Life Sciences Cardiology Cardiomegaly - chemically induced Cardiomegaly - drug therapy Cardiomegaly - pathology Cardiotoxicity - drug therapy Cardiotoxicity - etiology Cardiotoxicity - pathology Cardiovascular diseases Cell Biology Cell Line Chains Coronary artery disease CYP1B1 gene CYP1B1 protein Cytochrome P-450 Cytochrome P-450 CYP1B1 - antagonists & inhibitors Cytochrome P-450 CYP1B1 - metabolism Cytochrome P450 Cytochromes P450 Ethylenediaminetetraacetic acid Gene expression Heart Heart attack Heart diseases Heart enlargement Humans Hydroxyeicosatetraenoic Acids - adverse effects Hydroxyeicosatetraenoic Acids - metabolism Hypertrophy Life Sciences Life Sciences & Biomedicine Liquid chromatography Markers Mass spectrometry Mass spectroscopy Medical Biochemistry Metabolites Muscle proteins Myocardial infarction Myosin Myosin Heavy Chains - metabolism Natriuretic peptides Oncology Protective Agents Protein expression Proteins Resveratrol Resveratrol - pharmacology Science & Technology Vasoconstrictor Agents - adverse effects
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