Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6

Lineage selective transcription factors (TFs) are important regulators of tumorigenesis, but their biological functions are often context dependent with undefined epigenetic mechanisms of action. In this study, we uncover a conditional role for the endodermal and pulmonary specifying TF GATA6 in lun...

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Veröffentlicht in:	Oncogene 2020-04, Vol.39 (18), p.3726-3737
Hauptverfasser:	Arnal-Estapé, Anna, Cai, Wesley L., Albert, Alexandra E., Zhao, Minghui, Stevens, Laura E., López-Giráldez, Francesc, Patel, Kiran D., Tyagi, Siddhartha, Schmitt, Earlene M., Westbrook, Thomas F., Nguyen, Don X.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/51 14/63 38/39 38/5 45/15 45/91 631/208/176 631/67/1612/1350 64/60 Adenocarcinoma Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - pathology Alveolar bone Analysis Animal models Animals Apoptosis Biochemistry & Molecular Biology Carcinogenesis - genetics Cell Biology Cell Differentiation - genetics Cell Lineage - genetics Cell proliferation Cell Proliferation - genetics Chromatin Chromatin - genetics Development and progression Disease Models, Animal Divergence DNA binding proteins Epigenetic inheritance Epigenetics Epithelial cells GATA6 Transcription Factor - genetics Gene Expression Regulation, Neoplastic - genetics Genetic engineering Genetic transformation Genetically modified organisms Genetics & Heredity Human Genetics Humans Internal Medicine Life Sciences & Biomedicine Lung - metabolism Lung - pathology Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Medicine Medicine & Public Health Mice Oncology Protein C Proto-Oncogene Proteins p21(ras) - genetics Science & Technology Surfactant protein C Transcription factors Tumor suppression Tumorigenesis Tumors
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