Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K-AKT-mTOR pathway in osteoarthritic chondrocytes

Panax notoginseng saponins (PNS) are active extracts obtained from the P. notoginseng plant. PNS exhibit various anti-inflammatory, anti-oxidant and anti-aging pharmacological properties in some cells. However, the effects of PNS on senescence and apoptosis in chondrocytes have not been studied to d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular medicine 2020-04, Vol.45 (4), p.1225-1236
Hauptverfasser:	Zhang, Yubiao, Cai, Weisong, Han, Guangtao, Zhou, Siqi, Li, Jianping, Chen, Mao, Li, Haohuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Anti-inflammatory agents Apoptosis Apoptosis - drug effects Arthritis Autophagy Cardiovascular disease Cartilage Cellular Senescence - drug effects Chondrocytes - metabolism Chondrocytes - pathology Collagen Destruction Disease Models, Animal Experiments Humans Inositol Kinases Laboratory animals Life Sciences & Biomedicine Male Medicine, Research & Experimental Membrane lipids Necrosis Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism Osteoarthritis - pathology Panax notoginseng - chemistry Pancreatitis Permeability Phosphatidylinositol 3-Kinases - metabolism Plant lipids Protein kinases Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Regulation Research & Experimental Medicine Saponins Saponins - chemistry Saponins - pharmacology Science & Technology Scientific equipment industry Senescence Software industry Studies Surgery TOR Serine-Threonine Kinases - metabolism Tumor necrosis factor Tumor necrosis factor-TNF Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!