Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies
Zingeber officinale (ginger) has been used for a long time in conventional medicine for the management of many diseases most important of which is inflammatory diseases. The aim of this study was formulation of topical microemulsion system to enhance the solubility, stability and release profile of...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2019-07, Vol.32 (4(Supplementary)), p.1873 |
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| container_issue | 4(Supplementary) |
| container_start_page | 1873 |
| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 32 |
| creator | Akram, Ayesha Akhtar, Naveed Waqas, Muhammad Khurram Rasul, Akhtar Rehman, Kashif Ur Khan, Jahangir Iqbal, Muhammad Khan, Barkat Ali |
| description | Zingeber officinale (ginger) has been used for a long time in conventional medicine for the management of many diseases most important of which is inflammatory diseases. The aim of this study was formulation of topical microemulsion system to enhance the solubility, stability and release profile of ginger extract, as it is unstable in the presence of light, air, heat and long term storage. The solubility of ginger extract in different oils, surfactants, and cosurfactants was determined in order to find the optimal components for microemulsion. Isopropyl myristate (IPM) was selected as oil phase, tween 80 and PEG 400 were selected as surfactant and co-surfactant respectively based on highest solubility values. Pseudo-ternary phase diagram was constructed in order to find out the microemulsion region. The prepared microemulsions were evaluated for pH, viscosity, conductivity, refractive index, globular size, zeta potential, polydispersity index, ginger extract content, in-vitro and ex-vivo release profiles. The formulation GE1 showed best physicochemical properties with smallest globular size (19.75nm), highest release rate and flux value. It also showed significant (p |
| format | Article |
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The aim of this study was formulation of topical microemulsion system to enhance the solubility, stability and release profile of ginger extract, as it is unstable in the presence of light, air, heat and long term storage. The solubility of ginger extract in different oils, surfactants, and cosurfactants was determined in order to find the optimal components for microemulsion. Isopropyl myristate (IPM) was selected as oil phase, tween 80 and PEG 400 were selected as surfactant and co-surfactant respectively based on highest solubility values. Pseudo-ternary phase diagram was constructed in order to find out the microemulsion region. The prepared microemulsions were evaluated for pH, viscosity, conductivity, refractive index, globular size, zeta potential, polydispersity index, ginger extract content, in-vitro and ex-vivo release profiles. The formulation GE1 showed best physicochemical properties with smallest globular size (19.75nm), highest release rate and flux value. It also showed significant (p<0.05) anti-inflammatory effect as compared to reference piroxicam drug solution. It is concluded that ginger extract can be used to develop stable microemulsion system with better skin permeation and promising antiinflammatory activity.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 31680086</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Administration, Cutaneous ; Analysis ; Animals ; Drug Delivery Systems - methods ; Emulsions - pharmacology ; Medical research ; Mice ; Myristates - chemistry ; Plant Extracts - pharmacology ; Polyethylene Glycols - chemistry ; Polysorbates - chemistry ; Skin - metabolism ; Skin Absorption - drug effects ; Solubility - drug effects ; Surface active agents ; Surface-Active Agents - chemistry ; Viscosity - drug effects ; Zingiber officinale - chemistry</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2019-07, Vol.32 (4(Supplementary)), p.1873</ispartof><rights>COPYRIGHT 2019 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31680086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akram, Ayesha</creatorcontrib><creatorcontrib>Akhtar, Naveed</creatorcontrib><creatorcontrib>Waqas, Muhammad Khurram</creatorcontrib><creatorcontrib>Rasul, Akhtar</creatorcontrib><creatorcontrib>Rehman, Kashif Ur</creatorcontrib><creatorcontrib>Khan, Jahangir</creatorcontrib><creatorcontrib>Iqbal, Muhammad</creatorcontrib><creatorcontrib>Khan, Barkat Ali</creatorcontrib><title>Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Zingeber officinale (ginger) has been used for a long time in conventional medicine for the management of many diseases most important of which is inflammatory diseases. The aim of this study was formulation of topical microemulsion system to enhance the solubility, stability and release profile of ginger extract, as it is unstable in the presence of light, air, heat and long term storage. The solubility of ginger extract in different oils, surfactants, and cosurfactants was determined in order to find the optimal components for microemulsion. Isopropyl myristate (IPM) was selected as oil phase, tween 80 and PEG 400 were selected as surfactant and co-surfactant respectively based on highest solubility values. Pseudo-ternary phase diagram was constructed in order to find out the microemulsion region. The prepared microemulsions were evaluated for pH, viscosity, conductivity, refractive index, globular size, zeta potential, polydispersity index, ginger extract content, in-vitro and ex-vivo release profiles. The formulation GE1 showed best physicochemical properties with smallest globular size (19.75nm), highest release rate and flux value. It also showed significant (p<0.05) anti-inflammatory effect as compared to reference piroxicam drug solution. It is concluded that ginger extract can be used to develop stable microemulsion system with better skin permeation and promising antiinflammatory activity.</description><subject>Administration, Cutaneous</subject><subject>Analysis</subject><subject>Animals</subject><subject>Drug Delivery Systems - methods</subject><subject>Emulsions - pharmacology</subject><subject>Medical research</subject><subject>Mice</subject><subject>Myristates - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polysorbates - chemistry</subject><subject>Skin - metabolism</subject><subject>Skin Absorption - drug effects</subject><subject>Solubility - drug effects</subject><subject>Surface active agents</subject><subject>Surface-Active Agents - chemistry</subject><subject>Viscosity - drug effects</subject><subject>Zingiber officinale - chemistry</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1OwzAQhH0A0VJ4BeQHIMjOjx1zq0qBSpW4gMStcuJ1MErsynailqfHUNAeVrOabzWaMzSnhNKMEfo-Q5chfBLCSiHEBZoVlNWE1GyOjg8wQe_2A9h4i9sP6WUbwZsvGY2zWFqFYZL9eJJO487YDjyGQ_xx4t5JBQoPpvUOhrEPyXaPNxZPJnr3y68PSUwOe-hBBsAhjspAuELnWvYBrv_2Ar09rl9Xz9n25WmzWm6zLq9IzECXpKi4biUwQXmjVF5K1nKia85z0RQKmKqULJkqagUlk7rhBHhFdFlDYhfo7vS3kz3sjNXuJ3kaBSm1s6BNui9TTTkVpeAJuDkB-7EZQO323gzSH3f_pRXf8klqgw</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Akram, Ayesha</creator><creator>Akhtar, Naveed</creator><creator>Waqas, Muhammad Khurram</creator><creator>Rasul, Akhtar</creator><creator>Rehman, Kashif Ur</creator><creator>Khan, Jahangir</creator><creator>Iqbal, Muhammad</creator><creator>Khan, Barkat Ali</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20190701</creationdate><title>Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies</title><author>Akram, Ayesha ; Akhtar, Naveed ; Waqas, Muhammad Khurram ; Rasul, Akhtar ; Rehman, Kashif Ur ; Khan, Jahangir ; Iqbal, Muhammad ; Khan, Barkat Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g250t-ef40357fcae6917bdd24a6c70f87729b3de6d5da46d38de46afb70e750f48e403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Administration, Cutaneous</topic><topic>Analysis</topic><topic>Animals</topic><topic>Drug Delivery Systems - methods</topic><topic>Emulsions - pharmacology</topic><topic>Medical research</topic><topic>Mice</topic><topic>Myristates - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polysorbates - chemistry</topic><topic>Skin - metabolism</topic><topic>Skin Absorption - drug effects</topic><topic>Solubility - drug effects</topic><topic>Surface active agents</topic><topic>Surface-Active Agents - chemistry</topic><topic>Viscosity - drug effects</topic><topic>Zingiber officinale - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akram, Ayesha</creatorcontrib><creatorcontrib>Akhtar, Naveed</creatorcontrib><creatorcontrib>Waqas, Muhammad Khurram</creatorcontrib><creatorcontrib>Rasul, Akhtar</creatorcontrib><creatorcontrib>Rehman, Kashif Ur</creatorcontrib><creatorcontrib>Khan, Jahangir</creatorcontrib><creatorcontrib>Iqbal, Muhammad</creatorcontrib><creatorcontrib>Khan, Barkat Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akram, Ayesha</au><au>Akhtar, Naveed</au><au>Waqas, Muhammad Khurram</au><au>Rasul, Akhtar</au><au>Rehman, Kashif Ur</au><au>Khan, Jahangir</au><au>Iqbal, Muhammad</au><au>Khan, Barkat Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>32</volume><issue>4(Supplementary)</issue><spage>1873</spage><pages>1873-</pages><issn>1011-601X</issn><abstract>Zingeber officinale (ginger) has been used for a long time in conventional medicine for the management of many diseases most important of which is inflammatory diseases. The aim of this study was formulation of topical microemulsion system to enhance the solubility, stability and release profile of ginger extract, as it is unstable in the presence of light, air, heat and long term storage. The solubility of ginger extract in different oils, surfactants, and cosurfactants was determined in order to find the optimal components for microemulsion. Isopropyl myristate (IPM) was selected as oil phase, tween 80 and PEG 400 were selected as surfactant and co-surfactant respectively based on highest solubility values. Pseudo-ternary phase diagram was constructed in order to find out the microemulsion region. The prepared microemulsions were evaluated for pH, viscosity, conductivity, refractive index, globular size, zeta potential, polydispersity index, ginger extract content, in-vitro and ex-vivo release profiles. The formulation GE1 showed best physicochemical properties with smallest globular size (19.75nm), highest release rate and flux value. It also showed significant (p<0.05) anti-inflammatory effect as compared to reference piroxicam drug solution. It is concluded that ginger extract can be used to develop stable microemulsion system with better skin permeation and promising antiinflammatory activity.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>31680086</pmid></addata></record> |
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| ispartof | Pakistan journal of pharmaceutical sciences, 2019-07, Vol.32 (4(Supplementary)), p.1873 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Cutaneous Analysis Animals Drug Delivery Systems - methods Emulsions - pharmacology Medical research Mice Myristates - chemistry Plant Extracts - pharmacology Polyethylene Glycols - chemistry Polysorbates - chemistry Skin - metabolism Skin Absorption - drug effects Solubility - drug effects Surface active agents Surface-Active Agents - chemistry Viscosity - drug effects Zingiber officinale - chemistry |
| title | Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies |
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