Binding Constants of Maackia Amurensis Whole Extract and its Separate Flavanoids to Estradiol Receptors

Binding Constants of Maackia Amurensis Whole Extract and its Separate Flavanoids to Estradiol Receptors

Extract of Maackia amurensis containing genistein and resveratrol demonstrated competitive specific binding to estradiol receptors with more affinity for ERβ (average RBA = 6.25%) than for ERα (average RBA = 0.67%) in tests with experimental animals and clinical materials (endometrium biopsy). Assoc...

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Veröffentlicht in:Pharmaceutical chemistry journal 2019, Vol.52 (10), p.855-859
Hauptverfasser: Kareva, E. N., Tikhonov, D. A., Mironov, S. E., Fedoreev, S. A., Kulesh, N. I., Shimanovskii, N. L.
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Zusammenfassung:Extract of Maackia amurensis containing genistein and resveratrol demonstrated competitive specific binding to estradiol receptors with more affinity for ERβ (average RBA = 6.25%) than for ERα (average RBA = 0.67%) in tests with experimental animals and clinical materials (endometrium biopsy). Associated flavonoids in the extract bound insignificantly to ERs although they could have a potentiating effect in the whole extract. Therefore, M. amurensis extract contained various phytoestrogens that determined the therapeutic potential (effect on cell growth, inflammation, apoptosis, angiogenesis, carbohydrate and lipid metabolism).
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-1914-x